Results 311 to 320 of about 138,617 (359)

Decoding temporal miRNA signatures of semen under in vitro exposure for forensic time since deposition estimation using machine learning‐driven modeling

Interdisciplinary Medicine, EarlyView.
This study develops a novel miRNA‐based framework for estimating the time since deposition of semen stains, combining small RNA sequencing with machine learning. Time‐dependent miRNA modules were identified using Mfuzz clustering and WGCNA, followed by a multi‐stage feature selection pipeline that reduced 261 candidate miRNAs to a minimal 7‐miRNA panel.
Meiming Cai, Qiong Lan, Tong Xie, Qinglin Liu, Ming Zhao, Xiaolian Wu, Xin Shi, Ruonan Shen, Yiman Wu, Chen Mao, Bin Cong, Bofeng Zhu   +11 more
wiley   +1 more source

Anti-cancer mechanism of traditional Chinese medicine natural products targeting ferroptosis. [PDF]

Chin Med
Zhou J, Lu P, Guo M, Chen X, Chai K, Wang H, Zhou L, Zhai Y, Li J, Qiao C, Yang S, Luo H, Ye P, Wu J.   +13 more
europepmc   +1 more source

LncRNA NORAD and ferroptosis escape in breast cancer: a promising yet complex therapeutic axis

Guohua Ren, Ling Qiang, Shu Fang
openalex   +1 more source

Taking Into Account Insulin Resistance With Associated Hyperinsulinemia to Counteract the Development of Acute and Chronic Cardiovascular Diseases

Chronic Diseases and Translational Medicine, EarlyView.
Serafino Fazio, Flora Affuso
wiley   +1 more source

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Ferroptosis of smooth muscle cells in vascular diseases: from basic principles to clinical translation. [PDF]

Cell Death Discov
Yang Y, Nawabi AQ, Yao Y, Liu N.
europepmc   +1 more source

Cytosolic cytochrome c represses ferroptosis

Xinxin Song, Zhuan Zhou, Jiao Liu, Jingbo Li, Chunhua Yu, Herbert J. Zeh, Daniel J. Klionsky, Brent R. Stockwell, Jiayi Wang, Rui Kang, Guido Kroemer, Daolin Tang   +11 more
openalex   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

NAMPT inhibition induces ferroptosis via mitochondrial metabolic reprogramming to enhance tumour immunogenicity in glioblastoma. [PDF]

Front Immunol
Zhao D, Duan L, Ren H, Zhang H, Zhang M, Liu Z, Wang H, Lu W, Shi W, Hou Q, Li T, Li M.   +11 more
europepmc   +1 more source

Aberrant activation of epigenetic BRD9-DGAT1 axis promotes lipid droplets deposition and ferroptosis resistance in YAP-high prostate cancer

Xuejin Zhu, Zhimei Wen, Jinhai Wu, Sian Chen, Ran Xu, Bin Wang, Yingwen Zhu, Yanfei Chen   +7 more
openalex   +1 more source