Results 341 to 350 of about 109,999 (379)

Research progress on traditional Chinese medicine animal models of post‐stroke depression and pathological insights

Animal Models and Experimental Medicine, EarlyView.
Post‐stroke depression (PSD) animal model of traditional Chinese medicine (TCM) combined with disease and syndrome often uses western medicine surgery (including: middle cerebral artery embolization to construct cerebral ischemia, or brain injection of collagenase to construct cerebral hemorrhage) combined with other methods (including: isolation ...
Jielin Wang, Wenlu Ma, Wei Wu, Yujuan Fu, Hui Li   +4 more
wiley   +1 more source

The Molecular Interplay Between p53-Mediated Ferroptosis and Non-Coding RNAs in Cancer. [PDF]

Int J Mol Sci
Punziano C, Trombetti S, Grosso M, Tornesello ML, Faraonio R.   +4 more
europepmc   +1 more source

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

Annals of Neurology, EarlyView.
Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel, Thomas Klopstock, David R. Lynch, Francesca Maltecca, Mayank Verma, Berge A. Minassian, Frances M. Platt, Débora Farina Gonçalves, Hélène Puccio, Andreas Roos, Matthis Synofzik   +10 more
wiley   +1 more source

Targeting PTK2 by vaccarin alleviates osteoporosis through inhibiting ferroptosis via modulating P53 acetylation/succinylation. [PDF]

Cell Biol Toxicol
Wang Y, Wang C, Gong Y, Li Q, Liu M, Sun H.   +5 more
europepmc   +1 more source

Extracellular Vesicles in Calcium Oxalate Nephrolithiasis: Emerging Biomarkers and Therapeutic Potential

Advanced NanoBiomed Research, EarlyView.
Kidney stones cause significant pain and healthcare costs. Current prediction, diagnosis, and treatment options are limited. Extracellular vesicles (EVs), rich in proteins, lipids, and nucleic acids, offer a promising solution. This review explores the roles of EVs in kidney stone management, highlighting their potential as biomarkers and therapeutic ...
Wang Zhu, Xu Changzhi, Deng Qiong, Liang Hui   +3 more
wiley   +1 more source

hnRNPA2B1 restrains granulosa cell ferroptosis by m⁶A/SLC7A11 in premature ovarian failure. [PDF]

J Ovarian Res
Xiong J, He L, Zhang Y, Zhao X.
europepmc   +1 more source

Endogenously Triggered DNAzyme‐Based Nanostructures for Gene‐Combined Therapy

Advanced NanoBiomed Research, EarlyView.
DNAzymes show great promise for gene regulation and therapeutic use via controlled release triggered by endogenous factors. This review summarizes recent advances in designing and constructing nanoscale platforms enabling endogenously triggered release of DNAzyme.
Theoneste Muyizere, Julien Milon Essola, Eric Nyirimigabo, Janvier Mukiza, Jean Felix Mukerabigwi   +4 more
wiley   +1 more source

Bicyclic Selenenyl Sulfides with Tuned Bioreductive Step Rates Reveal Constraints for Probes Targeting Thioredoxin Reductase

Angewandte Chemie, EarlyView.
Thiol reductants activate dichalcogenide probes by a cascade of partly reversible steps. Careful dichalcogenide engineering can tune the rates of these steps separately, to aim at probes that are kinetically selective for specific oxidoreductases in live cells.
Lukas Zeisel, Lucas Dessen Weissenhorn, Karoline C. Scholzen, Andrea Madabeni, Laura Orian, Elias S. J. Arnér, Oliver Thorn‐Seshold   +6 more
wiley   +2 more sources

The Crosstalk Between Ferritinophagy and Ferroptosis in Ischemic Stroke: Regulatory Mechanisms and Therapeutic Implications. [PDF]

Cell Mol Neurobiol
Shi Z, Chen K, Wang Y, Du H.
europepmc   +1 more source

Exosomes in Intervertebral Disc Regeneration: Roles, Opportunities, and Challenges

Advanced NanoBiomed Research, EarlyView.
Factors of Intervertebral Disc Degeneration Extracellular Matrix (ECM) Exosomes and Intervertebral Disc Degeneration (IVDD) Exosome‐Mediated Therapy for IVDD of Different Cell Sources Application of Engineered Exosomes in IVDD Clinical Application of Exosomes in IVDD Treatment Conclusion and Future Perspectives. Intervertebral disc degeneration (IVDD),
Xianglong Zhou, Tianyi Xia, Jiheng Xiao, Jianhui Xiang, Hanhong Fang, Haoran Zhou, Yiqiang Hu, Liming Xiong   +7 more
wiley   +1 more source