Results 41 to 50 of about 147,915 (338)

Ferroptosis Patterns and Tumor Microenvironment Infiltration Characterization in Bladder Cancer

Frontiers in Cell and Developmental Biology, 2022
Background: Ferroptosis is a unique iron-dependent form of cell death and bladder cancer (BCa) is one of the top ten most common cancer types in the world.
Qi-Dong Xia, Jian-Xuan Sun, Chen-Qian Liu, Jin-Zhou Xu, Ye An, Meng-Yao Xu, Zheng Liu, Jia Hu, Shao-Gang Wang   +8 more
doaj   +1 more source

The role of autophagy in liver epithelial cells and its Impact on systemic homeostasis [PDF]

, 2019
Autophagy plays a role in several physiological and pathological processes as it controls the turnover rate of cellular components and influences cellular homeostasis.
Facchiano, Antonio, Gaudio, Eugenio, Giampietri, Claudia, Giulitti, Federico, Mancinelli, Romina, Mandatori, Sara, Moresi, Viviana, Petrungaro, Simonetta, Tomaipitinca, Luana, Ziparo, Elio   +9 more
core   +1 more source

Zinc transporter ZIP7 is a novel determinant of ferroptosis

Cell Death and Disease, 2021
Ferroptosis is a newly described form of regulated cell death triggered by oxidative stresses and characterized by extensive lipid peroxidation and membrane damages.
Po-Han Chen, Jianli Wu, Yitong Xu, Chien-Kuang Cornelia Ding, Alexander A. Mestre, Chao-Chieh Lin, Wen-Hsuan Yang, Jen-Tsan Chi   +7 more
doaj   +1 more source

Genomic analysis uncovers prognostic and immunogenic characteristics of ferroptosis for clear cell renal cell carcinoma

Molecular Therapy: Nucleic Acids, 2021
In this study, the characteristic patterns of ferroptosis in clear cell renal cell carcinoma (ccRCC) were systematically investigated with the interactions between ferroptosis and the tumor microenvironment (TME).
Dan Bai, Huhu Feng, Jiajun Yang, Aiping Yin, Xiao Lin, Airong Qian, Hiroshi Sugiyama   +6 more
doaj   +1 more source

Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice [PDF]

, 2017
Background: The phosphorylation of eukaryotic initiation factor 2 (p-eIF2) during dietary amino acid insufficiency reduces protein synthesis and alters gene expression via the integrated stress response (ISR).Objective: We explored whether a Met ...
Anthony, Tracy G., Bargoud, Albert R., Gettys, Thomas W., Hamilton, Karyn L., Jonsson, William O., Kimball, Scot R., Miller, Benjamin F., Mirek, Emily T., Peelor, Frederick F., III, Pettit, Ashley P., Wang, Yongping, Wek, Ronald C.   +11 more
core   +1 more source

GPX4-independent ferroptosis—a new strategy in disease’s therapy

Cell Death Discovery, 2022
Ferroptosis is a form of programmed cell death characterized by intracellular iron accumulation and lipid peroxidation, and earlier studies identified glutathione peroxidase 4 (GPX4) as an essential regulator of this process.
Tianyu Ma, Jingtong Du, Yufeng Zhang, Yuyao Wang, Bingxuan Wang, Tianhong Zhang   +5 more
doaj   +1 more source

Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas. [PDF]

, 2019
Glioma is recognized to be a highly heterogeneous CNS malignancy, whose diverse cellular composition and cellular interactions have not been well characterized. To gain new clinical- and biological-insights into the genetically-bifurcated IDH1 mutant (mt)
Adkins, Jonathan, Al-Kofahi, Yousef, Barnholtz-Sloan, Jill S, Berens, Michael E, Byron, Sara A, Cho, Sanghee, Couce, Marta, Cuyugan, Lori, Devine, Karen, Dinn, Sean, Ginty, Fiona, Graf, John F, Halperin, Rebecca F, Kiefer, Jeffrey, Kim, Seungchan, Liang, Winnie S, McDonough, Elizabeth, Nasser, Sara, Nelson, Sarah J, Ostrom, Quinn, Phillips, Joanna J, Prados, Michael, Rusu, Mirabela, Schyberg, Shannon, Sloan, Andrew E, Sood, Anup, Wolansky, Leo, Zavodszky, Maria I   +27 more
core   +1 more source

Role and mechanism of ferroptosis in neurological diseases

Molecular Metabolism, 2022
Background: Ferroptosis, as a new form of cell death, is different from other cell deaths such as autophagy or senescence. Ferroptosis involves in the pathophysiological progress of several diseases, including cancers, cardiovascular diseases, nervous ...
Mengmeng Ou, Ying Jiang, Yingying Ji, Qin Zhou, Zhiqiang Du, Haohao Zhu, Zhenhe Zhou   +6 more
doaj   +1 more source

Molecular mechanisms of cell death:recommendations of the Nomenclature Committee on Cell Death 2018 [PDF]

, 2018
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives.
Aaronson, Stuart A., Abrams, John M., Adam, Dieter, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Annicchiarico-Petruzzelli, Margherita, Antonov, Alexey V., Arama, Eli, Baehrecke, Eric H., Barlev, Nickolai A., Bazan, Nicolas G., Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Katiuscia, Blagosklonny, Mikhail V., Blomgren, Klas, Borner, Christoph, Boya, Patricia, Brenner, Catherine, Campanella, Michelangelo, Candi, Eleonora, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K. -M., Chandel, Navdeep S., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Cohen, Gerald M., Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D'Angiolella, Vincenzo, Dawson, Ted M., Dawson, Valina L., De laurenzi, Vincenzo, De Maria, Ruggero, Debatin, Klaus-Michael, DeBerardinis, Ralph J., Deshmukh, Mohanish, Di Daniele, Nicola, Di Virgilio, Francesco, Dixit, Vishva M., Dixon, Scott J., Duckett, Colin S., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Fimia, Gian Maria, Fulda, Simone, Galluzzi, Lorenzo, Garcia-Saez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Golstein, Pierre, Gottlieb, Eyal, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Gross, Atan, Hajnoczky, Gyorgy, Hardwick, J. Marie, Harris, Isaac S., Heiden, Matthew G. Vander, Hengartner, Michael O., Hetz, Claudio, Ichijo, Hidenori, Jaattela, Marja, Joseph, Bertrand, Jost, Philipp J., Juin, Philippe P., Kaiser, William J., Karin, Michael, Kaufmann, Thomas, Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Knight, Richard A., Kroemer, Guido, Kumar, Sharad, Lee, Sam W., Lemasters, John J., Levine, Beth, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., Lopez-Otin, Carlos, Lowe, Scott W., Luedde, Tom, Lugli, Enrico, MacFarlane, Marion, Madeo, Frank, Malewicz, Michal, Malorni, Walter, Manic, Gwenola, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A., Molkentin, Jeffery D., Moll, Ute M., Munoz-Pinedo, Cristina, Nagata, Shigekazu, Nunez, Gabriel, Oberst, Andrew, Oren, Moshe, Overholtzer, Michael, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Piacentini, Mauro, Pinton, Paolo, Prehn, Jochen H. M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rehm, Markus, Rizzuto, Rosario, Rodrigues, Cecilia M. P., Rubinsztein, David C., Rudel, Thomas, Ryan, Kevin M., Sayan, Emre, Scorrano, Luca, Shao, Feng, Shi, Yufang, Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stockwell, Brent R., Strasser, Andreas, Szabadkai, Gyorgy, Tait, Stephen W. G., Tang, Daolin, Tavernarakis, Nektarios, Thorburn, Andrew, Tsujimoto, Yoshihide, Turk, Boris, Vanden Berghe, Tom, Vandenabeele, Peter, Villunger, Andreas, Virgin, Herbert W., Vitale, Ilio, Vousden, Karen H., Vucic, Domagoj, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ying, Wells, James A., Wood, Will, Yuan, Junying, Zakeri, Zahra, Zhivotovsky, Boris, Zitvogel, Laurence   +168 more
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Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

Protein & Cell, 2020
The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers.
Pranavi Koppula, Zhuang Li, B. Gan
semanticscholar   +1 more source