Results 41 to 50 of about 109,999 (379)
Silibinin Inhibits Cell Ferroptosis and Ferroptosis-Related Tissue Injuries
Antioxidants, 2023 Ferroptosis is involved in various tissue injuries including neurodegeneration, ischemia-reperfusion injury, and acute liver injury. Ferroptosis inhibitors exhibit promising clinical potential in the treatment of various diseases.
Wentao Duan +11 more
doaj +1 more source
Opportunities and challenges related to ferroptosis in glioma and neuroblastoma
Frontiers in Oncology, 2023 A newly identified form of cell death known as ferroptosis is characterized by the peroxidation of lipids in response to iron. Rapid progress in research on ferroptosis in glioma and neuroblastoma has promoted the exploitation of ferroptosis in related ...
Huizhong Chi +13 more
doaj +1 more source
Cell, 2020 Ferroptosis is a regulated form of cell death that occurs when phospholipids with polyunsaturated fatty acyl tails are oxidized in an iron-dependent manner. Research in recent years has uncovered complex cellular networks that induce and suppress lethal lipid peroxidation.
Hadian, K., Stockwell, B.R.
openaire +3 more sources
The Mechanism of Ferroptosis and Applications in Tumor Treatment
Frontiers in Pharmacology, 2020 Iron-dependent ferroptosis is a new form of cell death in recent years, which is driven by lipid peroxidation. The lethal lipid accumulation caused by glutathione depletion or inactivation of glutathione peroxidase 4 (GPX4) is characteristic of the ...
Xinyue Lin +4 more
doaj +1 more source
Role of ferroptosis on tumor progression and immunotherapy
Cell Death Discovery, 2022 Ferroptosis is triggered by intracellular iron leading to accumulation of lipid peroxidation consequent promotion of cell death. Cancer cell exhibits ability to evade ferroptosis by activation of antioxidant signaling pathways such as SLC7A11/GPX4 axis ...
Deting Gong +4 more
doaj +1 more source
Ferroptosis and Liver Fibrosis [PDF]
International Journal of Medical Sciences, 2021 Ferroptosis is an iron-dependent form of regulated cell death, which is characterized by a large amount of lipid peroxide accumulation and the imbalance of redox state in cells. Ferroptosis is usually accompanied with the dysfunction of lipid repair enzyme (glutathione peroxidase 4, GPX4), large masses of iron accumulation and lipid peroxidation of ...
Qiang Xia, Yi Luo, Qi Pan, Kang He
openaire +2 more sources
Induction and application of ferroptosis in cancer therapy
Cancer Cell International, 2022 At present, more than one cell death pathways have been found, one of which is ferroptosis. Ferroptosis was discovered in 2012 and described as an iron-dependent and lipid peroxidation-driven regulated cell death pathway.
Qing Nie +4 more
doaj +1 more source
Ferroptosis in Neurological Diseases [PDF]
Frontiers in Cellular Neuroscience, 2020 Ferroptosis is mechanism for non-apoptotic, iron-dependent, oxidative cell death that is characterized by glutathione consumption and lipid peroxides accumulation. Ferroptosis is crucially involved in neurological diseases, including neurodegeneration, stroke and neurotrauma.
Jia-Xin Ren +5 more
openaire +4 more sources
Ferroptosis in immunostimulation and immunosuppression
Immunological Reviews, 2023 SummaryFerroptosis is a form of iron‐dependent regulated cell death characterized by the accumulation of toxic lipid peroxides, particularly in the plasma membrane, leading to lytic cell death. While it plays a crucial role in maintaining the overall health and proper functioning of multicellular organisms, it can also contribute to tissue damage and ...
Daolin Tang, Guido Kroemer, Rui Kang
openaire +3 more sources
Copper-dependent autophagic degradation of GPX4 drives ferroptosis
Autophagy, 2023 Ferroptosis is a type of iron-dependent regulated cell death characterized by unrestricted lipid peroxidation and membrane damage. Although GPX4 (glutathione peroxidase 4) plays a master role in blocking ferroptosis by eliminating phospholipid ...
Qian Xue +9 more
semanticscholar +1 more source