Results 31 to 40 of about 112,447 (264)

Targeting ferroptosis in breast cancer

Biomarker Research, 2020
Ferroptosis is a recently discovered distinct type of regulated cell death caused by the accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the occurrence of ferroptosis, making it a promising therapeutic target to manage
Zhaoqing Li, Lini Chen, Cong Chen, Yulu Zhou, Dengdi Hu, Jingjing Yang, Yongxia Chen, Wenying Zhuo, Misha Mao, Xun Zhang, Ling Xu, Linbo Wang, Jichun Zhou   +12 more
doaj   +1 more source

Autophagy mediates an amplification loop during ferroptosis

Cell Death and Disease, 2023
Ferroptosis, a programmed cell death, has been identified and associated with cancer and various other diseases. Ferroptosis is defined as a reactive oxygen species (ROS)-dependent cell death related to iron accumulation and lipid peroxidation, which is ...
Seunghee Lee, Narae Hwang, Byeong Geun Seok, Sangguk Lee, Seon-Jin Lee, Su Wol Chung   +5 more
doaj   +1 more source

Role and mechanism of ferroptosis in neurological diseases

Molecular Metabolism, 2022
Background: Ferroptosis, as a new form of cell death, is different from other cell deaths such as autophagy or senescence. Ferroptosis involves in the pathophysiological progress of several diseases, including cancers, cardiovascular diseases, nervous ...
Mengmeng Ou, Ying Jiang, Yingying Ji, Qin Zhou, Zhiqiang Du, Haohao Zhu, Zhenhe Zhou   +6 more
doaj   +1 more source

Ferroptosis and kidney disease

, 2020
La muerte celular es un proceso minuciosamente regulado que se desarrolla a través de diferentes vías. La muerte celular regulada, ya sea mediante apoptosis o necrosis regulada, ofrece la posibilidad de introducir una intervención terapéutica.
Fontecha-Barriuso, Miguel, Sanchez-Niño, Maria D., Moreno, Juan A., Martin-Sanchez, Diego, Ramos, Adrian M., Martinez-Moreno, Julio M., Sanz, Ana B., Guerrero-Hue, Melania, Ortiz, Alberto   +8 more
core   +1 more source

Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation

Cell Death Discovery, 2023
Alcohol abuse is a significant cause of global morbidity and mortality, with alcoholic liver disease (ALD) being a common consequence. The pathogenesis of ALD involves various cellular processes, including oxidative stress, inflammation, and hepatic cell
Jiao Luo, Ge Song, Ningning Chen, Mengyue Xie, Xuan Niu, Shuyue Zhou, Yanan Ji, Xiaoxiao Zhu, Wanli Ma, Qianqian Zhang, Dianke Yu   +10 more
doaj   +1 more source

Zinc transporter ZIP7 is a novel determinant of ferroptosis

Cell Death and Disease, 2021
Ferroptosis is a newly described form of regulated cell death triggered by oxidative stresses and characterized by extensive lipid peroxidation and membrane damages.
Po-Han Chen, Jianli Wu, Yitong Xu, Chien-Kuang Cornelia Ding, Alexander A. Mestre, Chao-Chieh Lin, Wen-Hsuan Yang, Jen-Tsan Chi   +7 more
doaj   +1 more source

Cadmium induces liver dysfunction and ferroptosis through the endoplasmic stress-ferritinophagy axis

Ecotoxicology and Environmental Safety, 2022
Cadmium (Cd) is a type of high-risk heavy metal that can damage organs such as the liver, but its mechanism is not yet clear. Ferroptosis is a newly discovered mode of regulatory cell death. We explored whether ferroptosis is involved in Cd-induced liver
Zhaoqi He, Peng Shen, Lianjun Feng, Haoyang Hao, Yuhong He, Guyue Fan, Zhuoyu Liu, Kun Zhu, Yiqi Wang, Naisheng Zhang, Xiaoyu Hu, Yunhe Fu, Jiacheng Wu   +12 more
doaj   +1 more source

Ferritinophagy and ferroptosis in the management of metabolic diseases [PDF]

, 2021
Ferroptosis is a form of regulated cell death modality associated with disturbed iron-homeostasis and unrestricted lipid peroxidation. Ample evidence has depicted an essential role for ferroptosis as either the cause or consequence for human diseases ...
Klionsky, DJ, Richardson, DR, Aslkhodapasandhokmabad, Hami, Wang, Shuyi, Tang, D, Tuomilehto, J, Tang, Daoli, Richarrdson, DR, Tuomeilehto, J, Ren, J, Penninger, JM, Ajoolabady, Amir, Zhou, H, Kionsky, Daniel . J., Wang, S, Kroemer, Guido, Lip, GYH, Kroemer, G, Libby, Peter, Zhou, Hao, Richarrdson, Des. R., Ren, Jun, Tuomilehto, Jaakko, Penninger, Josef M., Aslkhodapasandhokmabad, H, Lip, Gregory Y. H., Ajoolabady, A, Libby, P   +27 more
core   +1 more source

Ultrasmall iron oxide nanoparticles induced ferroptosis via Beclin1/ATG5-dependent autophagy pathway

Nano Convergence, 2021
Iron-based nanoparticles, which could elicit ferroptosis, is becoming a promising new way to inhibit tumor cell growth. Notably, ultrasmall iron oxide nanoparticles (USIONPs) have been found to upregulate the autophagy process in glioblastoma (GBM) cells.
Jian Wen, Hanren Chen, Zhongyu Ren, Peng Zhang, Jianjiao Chen, Shulian Jiang   +5 more
doaj   +1 more source

Identification of Potential Ferroptosis Key Genes in the Pathogenesis of Lumbosacral Spinal Root Avulsion by RNA Sequencing and Bioinformatics Analysis

Frontiers in Molecular Biosciences, 2022
Objective: Ferroptosis is a type of cell death involved in various human diseases, including nerve injury. However, the role of ferroptosis in lumbosacral spinal root avulsion (LSRA) remains unknown.
Zhibin Zhou, Jiajia Lu, Jun Ma, Lei Zhu
doaj   +1 more source