Results 31 to 40 of about 89,109 (264)

Ferritinophagy and ferroptosis in the management of metabolic diseases [PDF]

, 2021
Ferroptosis is a form of regulated cell death modality associated with disturbed iron-homeostasis and unrestricted lipid peroxidation. Ample evidence has depicted an essential role for ferroptosis as either the cause or consequence for human diseases ...
Klionsky, DJ, Richardson, DR, Aslkhodapasandhokmabad, Hami, Wang, Shuyi, Tang, D, Tuomilehto, J, Tang, Daoli, Richarrdson, DR, Tuomeilehto, J, Ren, J, Penninger, JM, Ajoolabady, Amir, Zhou, H, Kionsky, Daniel . J., Wang, S, Kroemer, Guido, Lip, GYH, Kroemer, G, Libby, Peter, Zhou, Hao, Richarrdson, Des. R., Ren, Jun, Tuomilehto, Jaakko, Penninger, Josef M., Aslkhodapasandhokmabad, H, Lip, Gregory Y. H., Ajoolabady, A, Libby, P   +27 more
core   +1 more source

NRF2, a Superstar of Ferroptosis

Antioxidants, 2023
Ferroptosis is an iron-dependent and lipid peroxidation-driven cell death cascade, occurring when there is an imbalance of redox homeostasis in the cell. Nuclear factor erythroid 2-related factor 2 (NFE2L2, also known as NRF2) is key for cellular antioxidant responses, which promotes downstream genes transcription by binding to their antioxidant ...
Ruihan Yan, Bingyi Lin, Wenwei Jin, Ling Tang, Shuming Hu, Rong Cai   +5 more
openaire   +3 more sources

Ferroptosis and Liver Fibrosis [PDF]

International Journal of Medical Sciences, 2021
Ferroptosis is an iron-dependent form of regulated cell death, which is characterized by a large amount of lipid peroxide accumulation and the imbalance of redox state in cells. Ferroptosis is usually accompanied with the dysfunction of lipid repair enzyme (glutathione peroxidase 4, GPX4), large masses of iron accumulation and lipid peroxidation of ...
Pan, Qi, Luo, Yi, Xia, Qiang, He, Kang
openaire   +2 more sources

Ferroptosis: process and function [PDF]

Cell Death & Differentiation, 2016
Ferroptosis is a recently recognized form of regulated cell death. It is characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture.
Y, Xie, W, Hou, X, Song, Y, Yu, J, Huang, X, Sun, R, Kang, D, Tang   +7 more
openaire   +2 more sources

Ferroptosis in acute leukemia

Chinese Medical Journal, 2023
Abstract Ferroptosis is an iron-dependent cell death pathway that is different from apoptosis, pyroptosis, and necrosis. The main characteristics of ferroptosis are the Fenton reaction mediated by intracellular free divalent iron ions, lipid peroxidation of cell membrane lipids, and inhibition of the anti-lipid peroxidation ...
Tianxin Lyu, Xudong Li, Yongping Song, Ting Gao, Xiuyuan Hao   +4 more
openaire   +3 more sources

Ferroptosis and Autoimmune Diseases

Frontiers in Immunology, 2022
Adequate control of autoimmune diseases with an unclear etiology resulting from autoreactivation of the immune system remains a major challenge. One of the factors that trigger autoimmunity is the abnormal induction of cell death and the inadequate clearance of dead cells that leads to the exposure or release of intracellular contents that activate the
Benjamin Lai, Chien-Hsiang Wu, Chao-Yi Wu, Chao-Yi Wu, Shue-Fen Luo, Jenn-Haung Lai, Jenn-Haung Lai   +6 more
openaire   +3 more sources

Ferroptosis in plants: regulation of lipid peroxidation and redox status [PDF]

, 2022
Regulated cell death (RCD) is an essential process that plays key roles along the plant life cycle. Unlike accidental cell death, which is an uncontrolled biological process, RCD involves integrated signaling cascades and precise molecular-mediated ...
Distefano, Ayelen Mariana, Zabaleta, Eduardo Julian, Bauer, María Victoria, Lopez, Gabriel Alejandro, Pagnussat, Gabriela Carolina   +4 more
core   +1 more source

miR-16-5p Regulates Ferroptosis by Targeting SLC7A11 in Adriamycin-Induced Ferroptosis in Cardiomyocytes

, 2023
Yongquan Chen, Yecheng Deng, Linghua Chen, Ziyao Huang, Yi Yan, Zhaoqi Huang Department of Cardiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of ChinaCorrespondence: Zhaoqi Huang, Department of ...
Huang Z, Chen L, Chen Y, Yan Y, Deng Y
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source