Results 41 to 50 of about 119,861 (259)

Cadmium induces liver dysfunction and ferroptosis through the endoplasmic stress-ferritinophagy axis

Ecotoxicology and Environmental Safety, 2022
Cadmium (Cd) is a type of high-risk heavy metal that can damage organs such as the liver, but its mechanism is not yet clear. Ferroptosis is a newly discovered mode of regulatory cell death. We explored whether ferroptosis is involved in Cd-induced liver
Zhaoqi He, Peng Shen, Lianjun Feng, Haoyang Hao, Yuhong He, Guyue Fan, Zhuoyu Liu, Kun Zhu, Yiqi Wang, Naisheng Zhang, Xiaoyu Hu, Yunhe Fu, Jiacheng Wu   +12 more
doaj   +1 more source

Ultrasmall iron oxide nanoparticles induced ferroptosis via Beclin1/ATG5-dependent autophagy pathway

Nano Convergence, 2021
Iron-based nanoparticles, which could elicit ferroptosis, is becoming a promising new way to inhibit tumor cell growth. Notably, ultrasmall iron oxide nanoparticles (USIONPs) have been found to upregulate the autophagy process in glioblastoma (GBM) cells.
Jian Wen, Hanren Chen, Zhongyu Ren, Peng Zhang, Jianjiao Chen, Shulian Jiang   +5 more
doaj   +1 more source

Identification of Potential Ferroptosis Key Genes in the Pathogenesis of Lumbosacral Spinal Root Avulsion by RNA Sequencing and Bioinformatics Analysis

Frontiers in Molecular Biosciences, 2022
Objective: Ferroptosis is a type of cell death involved in various human diseases, including nerve injury. However, the role of ferroptosis in lumbosacral spinal root avulsion (LSRA) remains unknown.
Zhibin Zhou, Jiajia Lu, Jun Ma, Lei Zhu
doaj   +1 more source

Targeting ferroptosis opens new avenues for the development of novel therapeutics

Signal Transduction and Targeted Therapy, 2023
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics, including altered iron homeostasis, reduced defense against oxidative stress, and abnormal lipid peroxidation.
Shumin Sun, Jie Shen, Jianwei Jiang, Fudi Wang, Junxia Min   +4 more
doaj   +1 more source

Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis

mBio, 2023
Herpes simplex virus 1 (HSV-1) is a DNA virus belonging to the family Herpesviridae. HSV-1 infection causes severe neurological disease in the central nervous system (CNS), including encephalitis.
Xi-Qiu Xu, Tongran Xu, Wenting Ji, Chong Wang, Yujie Ren, Xiaobei Xiong, Xi Zhou, Shu-Hai Lin, Yi Xu, Yang Qiu   +9 more
doaj   +1 more source

miR-16-5p Regulates Ferroptosis by Targeting SLC7A11 in Adriamycin-Induced Ferroptosis in Cardiomyocytes

, 2023
Yongquan Chen, Yecheng Deng, Linghua Chen, Ziyao Huang, Yi Yan, Zhaoqi Huang Department of Cardiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of ChinaCorrespondence: Zhaoqi Huang, Department of ...
Huang Z, Chen L, Chen Y, Yan Y, Deng Y
core  

Ferroptosis in mitochondrial cardiomyopathy

, 2023
Ferroptosis is a form of necrotic cell death characterized by iron-dependent lipid peroxidation culminating in membrane rupture. Accumulating evidence links ferroptosis to multiple cardiac diseases and identifies mitochondria as important regulators of ...
Sofia Ahola, Ahola, S., Thomas Langer, Ahola, Sofia; id_orcid, Langer, T., Langer, Thomas   +5 more
core   +1 more source

Ferroptosis in plants: regulation of lipid peroxidation and redox status [PDF]

, 2022
Regulated cell death (RCD) is an essential process that plays key roles along the plant life cycle. Unlike accidental cell death, which is an uncontrolled biological process, RCD involves integrated signaling cascades and precise molecular-mediated ...
Distefano, Ayelen Mariana, Zabaleta, Eduardo Julian, Bauer, María Victoria, Lopez, Gabriel Alejandro, Pagnussat, Gabriela Carolina, Eduardo Zabaleta, Gabriela Carolina Pagnussat, Victoria Bauer, Gabriel Alejandro López, Ayelén Mariana Distéfano   +9 more
core   +1 more source

Modelling ferroptosis in IPEC-J2 cells: insights into iron-dependent cell death

Italian Journal of Animal Science
Ferroptosis, a form of regulated cell death characterised by iron accumulation and lipid peroxidation, plays a crucial role in various diseases. However, its mechanisms in livestock, particularly in pigs, remain unclear.
Ching-Hsuan Liu, Yuan-Yu Lin
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source