Results 21 to 30 of about 138,617 (359)
The Mechanism of Ferroptosis and Applications in Tumor Treatment
Frontiers in Pharmacology, 2020 Iron-dependent ferroptosis is a new form of cell death in recent years, which is driven by lipid peroxidation. The lethal lipid accumulation caused by glutathione depletion or inactivation of glutathione peroxidase 4 (GPX4) is characteristic of the ...
Xinyue Lin +4 more
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Role of ferroptosis on tumor progression and immunotherapy
Cell Death Discovery, 2022 Ferroptosis is triggered by intracellular iron leading to accumulation of lipid peroxidation consequent promotion of cell death. Cancer cell exhibits ability to evade ferroptosis by activation of antioxidant signaling pathways such as SLC7A11/GPX4 axis ...
Deting Gong +4 more
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Mechanisms of ferroptosis [PDF]
Cellular and Molecular Life Sciences, 2016 Ferroptosis is a non-apoptotic form of cell death that can be triggered by small molecules or conditions that inhibit glutathione biosynthesis or the glutathione-dependent antioxidant enzyme glutathione peroxidase 4 (GPX4). This lethal process is defined by the iron-dependent accumulation of lipid reactive oxygen species and depletion of plasma ...
Cao, Jennifer Yinuo, Dixon, Scott J.
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Lipid metabolism in ferroptosis and ferroptosis-based cancer therapy
Frontiers in Oncology, 2022 Ferroptosis refers to iron-dependent, specialized, and regulated-necrosis mediated by lipid peroxidation, which is closely related to a variety of diseases, including cancer. Tumor cells undergo extensive changes in lipid metabolism, including lipid peroxidation and ferroptosis. Changes in lipid metabolism are critical for the regulation of ferroptosis
Yonghao Sun +4 more
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A 3D cell death assay to quantitatively determine ferroptosis in spheroids [PDF]
, 2020 The failure of drug efficacy in clinical trials remains a big issue in cancer research. This is largely due to the limitations of two-dimensional (2D) cell cultures, the most used tool in drug screening.
Declercq, Heidi +4 more
core +1 more source
Autophagy mediates an amplification loop during ferroptosis
Cell Death and Disease, 2023 Ferroptosis, a programmed cell death, has been identified and associated with cancer and various other diseases. Ferroptosis is defined as a reactive oxygen species (ROS)-dependent cell death related to iron accumulation and lipid peroxidation, which is ...
Seunghee Lee +5 more
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Opportunities and challenges related to ferroptosis in glioma and neuroblastoma
Frontiers in Oncology, 2023 A newly identified form of cell death known as ferroptosis is characterized by the peroxidation of lipids in response to iron. Rapid progress in research on ferroptosis in glioma and neuroblastoma has promoted the exploitation of ferroptosis in related ...
Huizhong Chi +13 more
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Targeting ferroptosis in osteosarcoma
Journal of Bone Oncology, 2021 Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents, with high degree of malignancy and an extremely poor prognosis. Ferroptosis, a non-traditional mode of regulated cell death (RCD) characterised by iron-dependent accumulation of lipid reactive oxygen species (ROS), is closely associated with a variety of cancers.
Jiazheng Zhao +4 more
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Scientific Reports, 2022 Ferroptosis genes have recently been reported to be involved in regulating the development of cancer, but their potential role in breast cancer (BRCA) is not fully understood.
Lianli Yin, Yinghua Tang
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NFE2L1-mediated proteasome function protects from ferroptosis
Molecular Metabolism, 2022 Objective: Ferroptosis continues to emerge as a novel modality of cell death with important therapeutic implications for a variety of diseases, most notably cancer and degenerative diseases.
Stefan Kotschi +6 more
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