Results 11 to 20 of about 89,109 (264)
Current Biology, 2020 Iron is an essential micronutrient for microorganisms, plants, animals, and humans. However, iron overload can damage the organism through a variety of mechanisms, including the induction of cell death. Ferroptosis is defined as an iron-dependent form of regulated cell death caused by unrestricted lipid peroxidation and subsequent membrane damage ...
Daolin, Tang, Guido, Kroemer
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Ferroptosis in life: To be or not to be
Biomedicine & Pharmacotherapy, 2023 Ferroptosis is a novel type of programmed cell death, characterized by a dysregulated iron metabolism and accumulation of lipid peroxides. It features the alteration of mitochondria and aberrant accumulation of excessive iron as well as loss of the cysteine-glutathione-GPX4 axis.
Ling Xu +4 more
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Life, 2023 Quercetin is a flavonoid present in apples, onions, tea, red wines, and berries, and it has shown different beneficial effects, such as providing cardiovascular protection, possessing anti-inflammatory properties, and demonstrating anticancer activity, among others.
Alfredo Cruz-Gregorio +1 more
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The Hallmarks of Ferroptosis [PDF]
Annual Review of Cancer Biology, 2019 Ferroptosis is a nonapoptotic, iron-dependent form of cell death that can be activated in cancer cells by natural stimuli and synthetic agents. Three essential hallmarks define ferroptosis, namely: the loss of lipid peroxide repair capacity by the phospholipid hydroperoxidase GPX4, the availability of redox-active iron, and oxidation of ...
Dixon, Scott J., Stockwell, Brent R.
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Lipid Metabolism and Ferroptosis [PDF]
Biology, 2021 Ferroptosis is a type of iron-dependent regulated necrosis induced by lipid peroxidation that occurs in cellular membranes. Among the various lipids, polyunsaturated fatty acids (PUFAs) associated with several phospholipids, such as phosphatidylethanolamine (PE) and phosphatidylcholine (PC), are responsible for ferroptosis-inducing lipid peroxidation ...
Ji-Yoon Lee +4 more
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Anti-cancer effect of 3,6-epidioxy-1,10-bisaboladiene through inducing ferroptosis-like cell death [PDF]
, 2023 岩手大学博士（農学）原著論文 1. Usukhbayar N, Takano Y, Uesugi S, Muroi M, Osada H, Kimura K 3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation Free Radical Research 57(3), 208-222, 2023 2.
USUKHBAYAR, Narandulam
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Mechanisms of ferroptosis [PDF]
Cellular and Molecular Life Sciences, 2016 Ferroptosis is a non-apoptotic form of cell death that can be triggered by small molecules or conditions that inhibit glutathione biosynthesis or the glutathione-dependent antioxidant enzyme glutathione peroxidase 4 (GPX4). This lethal process is defined by the iron-dependent accumulation of lipid reactive oxygen species and depletion of plasma ...
Cao, Jennifer Yinuo, Dixon, Scott J.
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Ferroptosis-related DEGs in STS.
, 2022 Ferroptosis-related DEGs in STS.
Yi Zhao (14034) +4 more
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Current Opinion in Physiology, 2022 Ferroptosis is a regulated iron-dependent cell death mechanism accompanied by the accumulation of peroxidized phospholipids, particularly phosphatidylethanolamine, in the cell. It occurs due to the disbalance between production and elimination of oxidized phospholipids in response to ferroptotic stimuli.
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DataSheet_1_A novel 25-ferroptosis-related gene signature for the prognosis of gliomas.docx
, 2023 BackgroundFerroptosis is closely associated with cancer and is of great importance in the immune evasion of cancer. However, the relationship between ferroptosis and glioma is unclear.MethodsWe downloaded the expression profiles and clinical data of ...
Chun Liu (47227) +7 more
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