Results 11 to 20 of about 119,861 (259)

Autophagy mediates an amplification loop during ferroptosis

Cell Death and Disease, 2023
Ferroptosis, a programmed cell death, has been identified and associated with cancer and various other diseases. Ferroptosis is defined as a reactive oxygen species (ROS)-dependent cell death related to iron accumulation and lipid peroxidation, which is ...
Seunghee Lee, Narae Hwang, Byeong Geun Seok, Sangguk Lee, Seon-Jin Lee, Su Wol Chung   +5 more
doaj   +2 more sources

Silibinin Inhibits Cell Ferroptosis and Ferroptosis-Related Tissue Injuries

Antioxidants, 2023
Ferroptosis is involved in various tissue injuries including neurodegeneration, ischemia-reperfusion injury, and acute liver injury. Ferroptosis inhibitors exhibit promising clinical potential in the treatment of various diseases.
Wentao Duan, Zexian Ou, Yuxing Huang, Yifan Zhang, Lan Zhang, Yanan Zhao, Ruikun He, Yihan Zhang, Yuanlong Ge, Huiling Lou, Zhenyu Ju, Qian Hu   +11 more
doaj   +2 more sources

Ferroptosis inhibitors: past, present and future [PDF]

Frontiers in Pharmacology
Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed the mechanisms of its formation and continue to explore effective ...
Lei Zhang, Yi Lin Luo, Yang Xiang, Xin Yue Bai, Rong Rong Qiang, Xin Zhang, Yan Ling Yang, Xiao Long Liu   +7 more
doaj   +2 more sources

Ferroptosis in health and disease. [PDF]

Mol Biomed
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids contained in membrane ...
Oyedokun PA, Ashonibare VJ, Akhigbe TM, Ashonibare PJ, Adeogun AE, Adegbola CA, Omole AI, Akhigbe RE.   +7 more
europepmc   +5 more sources

Circular RNAs in ferroptosis: regulation mechanism and potential clinical application in disease

Frontiers in Pharmacology, 2023
Ferroptosis, an iron-dependent non-apoptotic form of cell death, is reportedly involved in the pathogenesis of various diseases, particularly tumors, organ injury, and degenerative pathologies.
Fei Li, Pei-Feng Li, Xiao-Dan Hao
doaj   +1 more source

Exosomes and ferroptosis: roles in tumour regulation and new cancer therapies [PDF]

PeerJ, 2022
Research on the biological role of exosomes is rapidly developing, and recent evidence suggests that exosomal effects involve ferroptosis. Exosomes derived from different tissues inhibit ferroptosis, which increases tumour cell chemoresistance. Therefore,
Yixin Shi, Bingrun Qiu, Linyang Huang, Jie Lin, Yiling Li, Yiting Ze, Chenglong Huang, Yang Yao   +7 more
doaj   +2 more sources

HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1

Cell Reports, 2023
Summary: Solid tumors have developed robust ferroptosis resistance. The mechanism underlying ferroptosis resistance regulation in solid tumors, however, remains elusive.
Zhou Yang, Wei Su, Xiyi Wei, Shuang Qu, Dan Zhao, Jingwan Zhou, Yunjun Wang, Qing Guan, Chao Qin, Jun Xiang, Ke Zen, Bing Yao   +11 more
doaj   +1 more source

Ferroptosis-based drug delivery system as a new therapeutic opportunity for brain tumors

Frontiers in Oncology, 2023
The brain tumor is a kind of malignant tumor with brutal treatment, high recurrence rate, and poor prognosis, and the incidence and death rate is increasing yearly.
Yansheng Yao, Peng Ji, Hao Chen, Jianwen Ge, Yajing Xu, Peng Wang, Li Xu, Zhirong Yan   +7 more
doaj   +1 more source

Ferritinophagy and ferroptosis in the management of metabolic diseases [PDF]

, 2021
Ferroptosis is a form of regulated cell death modality associated with disturbed iron-homeostasis and unrestricted lipid peroxidation. Ample evidence has depicted an essential role for ferroptosis as either the cause or consequence for human diseases ...
Klionsky, DJ, Richardson, DR, Aslkhodapasandhokmabad, Hami, Wang, Shuyi, Tang, D, Tuomilehto, J, Tang, Daoli, Richarrdson, DR, Tuomeilehto, J, Ren, J, Penninger, JM, Ajoolabady, Amir, Zhou, H, Kionsky, Daniel . J., Wang, S, Kroemer, Guido, Lip, GYH, Kroemer, G, Libby, Peter, Zhou, Hao, Richarrdson, Des. R., Ren, Jun, Tuomilehto, Jaakko, Penninger, Josef M., Aslkhodapasandhokmabad, H, Lip, Gregory Y. H., Ajoolabady, A, Libby, P   +27 more
core   +1 more source

Cross Talk Between Ferroptosis and Cerebral Ischemia

Frontiers in Neuroscience, 2020
Recently, ferroptosis has been revealed as a new form of regulated cell death. Distinct from apoptosis and necrosis, ferroptosis is evoked by iron-dependent lipid peroxidation.
Xu She, Bin Lan, Haomei Tian, Biao Tang
doaj   +1 more source