Results 51 to 60 of about 72,927 (343)
Targeting ferroptosis in breast cancer
Biomarker Research, 2020 Ferroptosis is a recently discovered distinct type of regulated cell death caused by the accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the occurrence of ferroptosis, making it a promising therapeutic target to manage
Zhaoqing Li +12 more
doaj +1 more source
Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas. [PDF]
, 2019 Glioma is recognized to be a highly heterogeneous CNS malignancy, whose diverse cellular composition and cellular interactions have not been well characterized. To gain new clinical- and biological-insights into the genetically-bifurcated IDH1 mutant (mt)
Adkins, Jonathan +27 more
core +1 more source
Ferroptosis-Related Genes Are Potential Therapeutic Targets and the Model of These Genes Influences Overall Survival of NSCLC Patients [PDF]
, 2022 Background: Lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSCC) are two of the most common subtypes of non-small cell lung cancer (NSCLC), with high mortality rates and rising incidence worldwide.
Chen, J +8 more
core +1 more source
Ferroptosis and Autoimmune Diseases
Frontiers in Immunology, 2022 Adequate control of autoimmune diseases with an unclear etiology resulting from autoreactivation of the immune system remains a major challenge. One of the factors that trigger autoimmunity is the abnormal induction of cell death and the inadequate clearance of dead cells that leads to the exposure or release of intracellular contents that activate the
Benjamin Lai +6 more
openaire +3 more sources
Cell Reports, 2023 Summary: Solid tumors have developed robust ferroptosis resistance. The mechanism underlying ferroptosis resistance regulation in solid tumors, however, remains elusive.
Zhou Yang +11 more
doaj
Targeting ferroptosis opens new avenues for the development of novel therapeutics
Signal Transduction and Targeted Therapy, 2023 Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics, including altered iron homeostasis, reduced defense against oxidative stress, and abnormal lipid peroxidation.
Shumin Sun +4 more
doaj +1 more source
Redox homeostasis: The Golden Mean of healthy living [PDF]
, 2016 The notion that electrophiles serve as messengers in cell signaling is now widely accepted. Nonetheless, major issues restrain acceptance of redox homeostasis and redox signaling as components of main- tenance of a normal physiological steady state.
Forman, Henry Jay +2 more
core +2 more sources
Non-coding RNAs and ferroptosis: potential implications for cancer therapy [PDF]
, 2022 Ferroptosis is a recently defined form of regulated cell death, which is biochemically and morphologically distinct from traditional forms of programmed cell death such as apoptosis or necrosis.
Balihodzic, Amar +5 more
core +1 more source
Ferroptosis as a Biological Phase Transition I: avascular and vascular tumor growth [PDF]
arXiv, 2021 Herewith we discuss a network model of the ferroptosis avascular and vascular tumor growth based on our previous proposed framework. Chiefly, ferroptosis should be viewed as a first order phase transition characterized by a supercritical Andronov Hopf bifurcation, with the emergence of limit cycle.
arxiv
Autophagy mediates an amplification loop during ferroptosis
Cell Death and Disease, 2023 Ferroptosis, a programmed cell death, has been identified and associated with cancer and various other diseases. Ferroptosis is defined as a reactive oxygen species (ROS)-dependent cell death related to iron accumulation and lipid peroxidation, which is ...
Seunghee Lee +5 more
doaj +1 more source