Results 51 to 60 of about 155,094 (383)
Molecular Therapy: Nucleic Acids, 2021 In this study, the characteristic patterns of ferroptosis in clear cell renal cell carcinoma (ccRCC) were systematically investigated with the interactions between ferroptosis and the tumor microenvironment (TME).
Dan Bai +6 more
doaj +1 more source
Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase. [PDF]
, 2019 Human platelet ALOX12 (hALOX12 or h12-LOX) has been implicated in a variety of human diseases. The present study investigates the active site of hALOX12 to more thoroughly understand how it positions the substrate and achieves nearly perfect regio- and ...
Aleem, Ansari Mukhtar +7 more
core +2 more sources
Iron Metabolism in Ferroptosis [PDF]
Frontiers in Cell and Developmental Biology, 2020 Ferroptosis is a form of regulated cell death that is characterized by iron-dependent oxidative damage and subsequent plasma membrane ruptures and the release of damage-associated molecular patterns. Due to the role of iron in mediating the production of reactive oxygen species and enzyme activity in lipid peroxidation, ferroptosis is strictly ...
Xin Chen +5 more
openaire +3 more sources
Role and mechanism of ferroptosis in neurological diseases
Molecular Metabolism, 2022 Background: Ferroptosis, as a new form of cell death, is different from other cell deaths such as autophagy or senescence. Ferroptosis involves in the pathophysiological progress of several diseases, including cancers, cardiovascular diseases, nervous ...
Mengmeng Ou +6 more
doaj +1 more source
Ferroptosis in cancer therapy: a novel approach to reversing drug resistance
Molecular Cancer, 2022 Ferroptosis is an intracellular iron-dependent form of cell death that is distinct from apoptosis, necrosis, and autophagy. Extensive studies suggest that ferroptosis plays a pivotal role in tumor suppression, thus providing new opportunities for cancer ...
Chen Zhang +4 more
semanticscholar +1 more source
Zinc transporter ZIP7 is a novel determinant of ferroptosis
Cell Death and Disease, 2021 Ferroptosis is a newly described form of regulated cell death triggered by oxidative stresses and characterized by extensive lipid peroxidation and membrane damages.
Po-Han Chen +7 more
doaj +1 more source
Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas. [PDF]
, 2019 Glioma is recognized to be a highly heterogeneous CNS malignancy, whose diverse cellular composition and cellular interactions have not been well characterized. To gain new clinical- and biological-insights into the genetically-bifurcated IDH1 mutant (mt)
Adkins, Jonathan +27 more
core +1 more source
CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy
Nature, 2019 Cancer immunotherapy restores or enhances the effector function of CD8+ T cells in the tumour microenvironment1,2. CD8+ T cells activated by cancer immunotherapy clear tumours mainly by inducing cell death through perforin–granzyme and Fas–Fas ligand ...
Weimin Wang +29 more
semanticscholar +1 more source
Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice [PDF]
, 2017 Background: The phosphorylation of eukaryotic initiation factor 2 (p-eIF2) during dietary amino acid insufficiency reduces protein synthesis and alters gene expression via the integrated stress response (ISR).Objective: We explored whether a Met ...
Anthony, Tracy G. +11 more
core +1 more source
GPX4-independent ferroptosis—a new strategy in disease’s therapy
Cell Death Discovery, 2022 Ferroptosis is a form of programmed cell death characterized by intracellular iron accumulation and lipid peroxidation, and earlier studies identified glutathione peroxidase 4 (GPX4) as an essential regulator of this process.
Tianyu Ma +5 more
doaj +1 more source