Results 51 to 60 of about 115,871 (339)
Molecular Therapy: Nucleic Acids, 2021 In this study, the characteristic patterns of ferroptosis in clear cell renal cell carcinoma (ccRCC) were systematically investigated with the interactions between ferroptosis and the tumor microenvironment (TME).
Dan Bai +6 more
doaj +1 more source
Molecular mechanisms of cell death:recommendations of the Nomenclature Committee on Cell Death 2018 [PDF]
, 2018 Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives.
Aaronson, Stuart A. +168 more
core +23 more sources
Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase. [PDF]
, 2019 Human platelet ALOX12 (hALOX12 or h12-LOX) has been implicated in a variety of human diseases. The present study investigates the active site of hALOX12 to more thoroughly understand how it positions the substrate and achieves nearly perfect regio- and ...
Aleem, Ansari Mukhtar +7 more
core +2 more sources
Ferroptosis and kidney disease
Nefrología (English Edition), 2020 Cell death is a finely regulated process occurring through different pathways. Regulated cell death, either through apoptosis or regulated necrosis offers the possibility of therapeutic intervention. Necroptosis and ferroptosis are among the best studied forms of regulated necrosis in the context of kidney disease.
Alberto Ortiz +8 more
openaire +4 more sources
Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice [PDF]
, 2017 Background: The phosphorylation of eukaryotic initiation factor 2 (p-eIF2) during dietary amino acid insufficiency reduces protein synthesis and alters gene expression via the integrated stress response (ISR).Objective: We explored whether a Met ...
Anthony, Tracy G. +11 more
core +1 more source
GPX4-independent ferroptosis—a new strategy in disease’s therapy
Cell Death Discovery, 2022 Ferroptosis is a form of programmed cell death characterized by intracellular iron accumulation and lipid peroxidation, and earlier studies identified glutathione peroxidase 4 (GPX4) as an essential regulator of this process.
Tianyu Ma +5 more
doaj +1 more source
The endocannabinoid, anandamide, induces cannabinoid receptor-independent cell death in renal proximal tubule cells [PDF]
, 2017 Background: The endocannabinoid (EC) system is well characterized in the central nervous system but scarcely studied in peripheral organs. In this paper, we newly identify the effect of the EC anandamide (AEA) upon renal proximal tubule cells. Methods:
Barrett, David A. +11 more
core +3 more sources
Ferroptosis in immunostimulation and immunosuppression
Immunological Reviews, 2023 SummaryFerroptosis is a form of iron‐dependent regulated cell death characterized by the accumulation of toxic lipid peroxides, particularly in the plasma membrane, leading to lytic cell death. While it plays a crucial role in maintaining the overall health and proper functioning of multicellular organisms, it can also contribute to tissue damage and ...
Daolin Tang, Guido Kroemer, Rui Kang
openaire +2 more sources
Role and mechanism of ferroptosis in neurological diseases
Molecular Metabolism, 2022 Background: Ferroptosis, as a new form of cell death, is different from other cell deaths such as autophagy or senescence. Ferroptosis involves in the pathophysiological progress of several diseases, including cancers, cardiovascular diseases, nervous ...
Mengmeng Ou +6 more
doaj +1 more source
NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis [PDF]
, 2017 Environmental nutrient levels impact cancer cell metabolism, resulting in context-dependent gene essentiality. Here, using loss-of-function screening based on RNA interference, we show that environmental oxygen levels are a major driver of differential ...
Adams, Sylvia +8 more
core +1 more source