Results 51 to 60 of about 147,915 (338)
Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase. [PDF]
, 2019 Human platelet ALOX12 (hALOX12 or h12-LOX) has been implicated in a variety of human diseases. The present study investigates the active site of hALOX12 to more thoroughly understand how it positions the substrate and achieves nearly perfect regio- and ...
Aleem, Ansari Mukhtar +7 more
core +2 more sources
Copper-dependent autophagic degradation of GPX4 drives ferroptosis
Autophagy, 2023 Ferroptosis is a type of iron-dependent regulated cell death characterized by unrestricted lipid peroxidation and membrane damage. Although GPX4 (glutathione peroxidase 4) plays a master role in blocking ferroptosis by eliminating phospholipid ...
Qian Xue +9 more
semanticscholar +1 more source
Mouse embryonic stem cell‐derived motor neurons are susceptible to ferroptosis
FEBS Open Bio, 2023 Ferroptosis is a regulated form of cell death driven by the lethal accumulation of lipid peroxides in cell membranes. Several regulators of ferroptosis have been identified using cancer cell lines. However, the cellular pathways of ferroptosis in neurons
Alejandra M. Martinez +4 more
doaj +1 more source
Targeting ferroptosis opens new avenues for the development of novel therapeutics
Signal Transduction and Targeted Therapy, 2023 Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics, including altered iron homeostasis, reduced defense against oxidative stress, and abnormal lipid peroxidation.
Shumin Sun +4 more
semanticscholar +1 more source
Highly efficient optogenetic cell ablation in C. elegans using membrane-targeted miniSOG. [PDF]
, 2016 The genetically encoded photosensitizer miniSOG (mini Singlet Oxygen Generator) can be used to kill cells in C. elegans. miniSOG generates the reactive oxygen species (ROS) singlet oxygen after illumination with blue light.
Chisholm, Andrew D, Xu, Suhong
core +1 more source
CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy
Nature, 2019 Cancer immunotherapy restores or enhances the effector function of CD8+ T cells in the tumour microenvironment1,2. CD8+ T cells activated by cancer immunotherapy clear tumours mainly by inducing cell death through perforin–granzyme and Fas–Fas ligand ...
Weimin Wang +29 more
semanticscholar +1 more source
The endocannabinoid, anandamide, induces cannabinoid receptor-independent cell death in renal proximal tubule cells [PDF]
, 2017 Background: The endocannabinoid (EC) system is well characterized in the central nervous system but scarcely studied in peripheral organs. In this paper, we newly identify the effect of the EC anandamide (AEA) upon renal proximal tubule cells. Methods:
Barrett, David A. +11 more
core +3 more sources
Ferroptosis: machinery and regulation
Autophagy, 2020 Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron-containing enzyme lipoxygenase is the main promoter of ferroptosis by
Xin Chen +4 more
semanticscholar +1 more source
ROS induced lipid peroxidation and their role in ferroptosis
Frontiers in Cell and Developmental Biology, 2023 Reactive oxygen species (ROS) play a crucial part in the process of cell death, including apoptosis, autophagy, and ferroptosis. ROS involves in the oxidation of lipids and generate 4-hydroxynonenal and other compounds associated with it. Ferroptosis may
H. Endale +2 more
semanticscholar +1 more source
Frontiers in Nutrition, 2021 Background: Iron is an essential nutrient involved in the redox cycle and the formation of free radicals. The reprogramming of iron metabolism is the main link to tumor cell survival.
Junfu Ma +6 more
doaj +1 more source