Results 61 to 70 of about 115,871 (339)

The role of microRNAs in ferroptosis

Frontiers in Molecular Biosciences, 2022
Ferroptosis is a newly discovered type of programmed cell death, which is closely related to the imbalance of iron metabolism and oxidative stress. Ferroptosis has become an important research topic in the fields of cardiomyopathy, tumors, neuronal injury disorders, and ischemia perfusion disorders.
Liqing Guo, Liqing Guo, Qingkun Zhang, Yuehui Liu   +3 more
openaire   +3 more sources

Mouse embryonic stem cell‐derived motor neurons are susceptible to ferroptosis

FEBS Open Bio, 2023
Ferroptosis is a regulated form of cell death driven by the lethal accumulation of lipid peroxides in cell membranes. Several regulators of ferroptosis have been identified using cancer cell lines. However, the cellular pathways of ferroptosis in neurons
Alejandra M. Martinez, Ahryun Kim, Cristina Aguilar Flores, Daoud F. Rahman, Wan Seok Yang   +4 more
doaj   +1 more source

Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas. [PDF]

, 2019
Glioma is recognized to be a highly heterogeneous CNS malignancy, whose diverse cellular composition and cellular interactions have not been well characterized. To gain new clinical- and biological-insights into the genetically-bifurcated IDH1 mutant (mt)
Adkins, Jonathan, Al-Kofahi, Yousef, Barnholtz-Sloan, Jill S, Berens, Michael E, Byron, Sara A, Cho, Sanghee, Couce, Marta, Cuyugan, Lori, Devine, Karen, Dinn, Sean, Ginty, Fiona, Graf, John F, Halperin, Rebecca F, Kiefer, Jeffrey, Kim, Seungchan, Liang, Winnie S, McDonough, Elizabeth, Nasser, Sara, Nelson, Sarah J, Ostrom, Quinn, Phillips, Joanna J, Prados, Michael, Rusu, Mirabela, Schyberg, Shannon, Sloan, Andrew E, Sood, Anup, Wolansky, Leo, Zavodszky, Maria I   +27 more
core   +1 more source

Ferroptosis in Cancer Progression

Cells, 2023
Ferroptosis is a newly discovered iron-dependent form of regulated cell death driven by phospholipid peroxidation and associated with processes including iron overload, lipid peroxidation, and dysfunction of cellular antioxidant systems. Ferroptosis is found to be closely related to many diseases, including cancer at every stage. Epithelial–mesenchymal
Rongyu Zhang, Jinghong Chen, Saiyang Wang, Wenlong Zhang, Quan Zheng, Rong Cai   +5 more
openaire   +3 more sources

Ultrasmall iron oxide nanoparticles induced ferroptosis via Beclin1/ATG5-dependent autophagy pathway

Nano Convergence, 2021
Iron-based nanoparticles, which could elicit ferroptosis, is becoming a promising new way to inhibit tumor cell growth. Notably, ultrasmall iron oxide nanoparticles (USIONPs) have been found to upregulate the autophagy process in glioblastoma (GBM) cells.
Jian Wen, Hanren Chen, Zhongyu Ren, Peng Zhang, Jianjiao Chen, Shulian Jiang   +5 more
doaj   +1 more source

Identification of Potential Ferroptosis Key Genes in the Pathogenesis of Lumbosacral Spinal Root Avulsion by RNA Sequencing and Bioinformatics Analysis

Frontiers in Molecular Biosciences, 2022
Objective: Ferroptosis is a type of cell death involved in various human diseases, including nerve injury. However, the role of ferroptosis in lumbosacral spinal root avulsion (LSRA) remains unknown.
Zhibin Zhou, Jiajia Lu, Jun Ma, Lei Zhu
doaj   +1 more source

Highly efficient optogenetic cell ablation in C. elegans using membrane-targeted miniSOG. [PDF]

, 2016
The genetically encoded photosensitizer miniSOG (mini Singlet Oxygen Generator) can be used to kill cells in C. elegans. miniSOG generates the reactive oxygen species (ROS) singlet oxygen after illumination with blue light.
Chisholm, Andrew D, Xu, Suhong
core   +1 more source

In defence of ferroptosis

Signal Transduction and Targeted Therapy
AbstractRampant phospholipid peroxidation initiated by iron causes ferroptosis unless this is restrained by cellular defences. Ferroptosis is increasingly implicated in a host of diseases, and unlike other cell death programs the physiological initiation of ferroptosis is conceived to occur not by an endogenous executioner, but by the withdrawal of ...
Francesca Alves, Darius Lane, Triet Phu Minh Nguyen, Ashley I. Bush, Scott Ayton   +4 more
openaire   +3 more sources

Ferroptosis: machinery and regulation [PDF]

Autophagy, 2020
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron-containing enzyme lipoxygenase is the main promoter of ferroptosis by producing lipid hydroperoxides, and its function relies on the activation of ACSL4-dependent lipid ...
Xin Chen, Xin Chen, Rui Kang, Daolin Tang, Daolin Tang, Daniel J. Klionsky, Jingbo Li   +6 more
openaire   +3 more sources

Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis

mBio, 2023
Herpes simplex virus 1 (HSV-1) is a DNA virus belonging to the family Herpesviridae. HSV-1 infection causes severe neurological disease in the central nervous system (CNS), including encephalitis.
Xi-Qiu Xu, Tongran Xu, Wenting Ji, Chong Wang, Yujie Ren, Xiaobei Xiong, Xi Zhou, Shu-Hai Lin, Yi Xu, Yang Qiu   +9 more
doaj   +1 more source