Results 61 to 70 of about 109,999 (379)
Exercise redox biochemistry:conceptual, methodological and technical recommendations [PDF]
, 2017 Exercise redox biochemistry is of considerable interest owing to its translational value in health and disease. However, unaddressed conceptual, methodological and technical issues complicate attempts to unravel how exercise alters redox homeostasis in ...
Bailey, Damian M. +3 more
core +10 more sources
NRF2, a Superstar of Ferroptosis
Antioxidants, 2023 Ferroptosis is an iron-dependent and lipid peroxidation-driven cell death cascade, occurring when there is an imbalance of redox homeostasis in the cell. Nuclear factor erythroid 2-related factor 2 (NFE2L2, also known as NRF2) is key for cellular antioxidant responses, which promotes downstream genes transcription by binding to their antioxidant ...
Ruihan Yan +5 more
openaire +3 more sources
Cell Reports, 2023 Summary: Solid tumors have developed robust ferroptosis resistance. The mechanism underlying ferroptosis resistance regulation in solid tumors, however, remains elusive.
Zhou Yang +11 more
doaj
Targeting ferroptosis in breast cancer
Biomarker Research, 2020 Ferroptosis is a recently discovered distinct type of regulated cell death caused by the accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the occurrence of ferroptosis, making it a promising therapeutic target to manage
Zhaoqing Li +12 more
doaj +1 more source
Autophagy mediates an amplification loop during ferroptosis
Cell Death and Disease, 2023 Ferroptosis, a programmed cell death, has been identified and associated with cancer and various other diseases. Ferroptosis is defined as a reactive oxygen species (ROS)-dependent cell death related to iron accumulation and lipid peroxidation, which is ...
Seunghee Lee +5 more
doaj +1 more source
Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas. [PDF]
, 2019 Glioma is recognized to be a highly heterogeneous CNS malignancy, whose diverse cellular composition and cellular interactions have not been well characterized. To gain new clinical- and biological-insights into the genetically-bifurcated IDH1 mutant (mt)
Adkins, Jonathan +27 more
core +1 more source
Ferroptosis and Autoimmune Diseases
Frontiers in Immunology, 2022 Adequate control of autoimmune diseases with an unclear etiology resulting from autoreactivation of the immune system remains a major challenge. One of the factors that trigger autoimmunity is the abnormal induction of cell death and the inadequate clearance of dead cells that leads to the exposure or release of intracellular contents that activate the
Benjamin Lai +6 more
openaire +3 more sources
Posttranslational Modifications in Ferroptosis [PDF]
Oxidative Medicine and Cellular Longevity, 2020 Ferroptosis was first coined in 2012 to describe the form of regulated cell death (RCD) characterized by iron-dependent lipid peroxidation. To date, ferroptosis has been implicated in many diseases, such as carcinogenesis, degenerative diseases (e.g., Huntington’s, Alzheimer’s, and Parkinson’s diseases), ischemia-reperfusion injury, and cardiovascular ...
Xiang Wei +3 more
openaire +2 more sources
Zinc transporter ZIP7 is a novel determinant of ferroptosis
Cell Death and Disease, 2021 Ferroptosis is a newly described form of regulated cell death triggered by oxidative stresses and characterized by extensive lipid peroxidation and membrane damages.
Po-Han Chen +7 more
doaj +1 more source
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
Protein & Cell, 2020 The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers.
Pranavi Koppula, Zhuang Li, B. Gan
semanticscholar +1 more source