Results 51 to 60 of about 31,457 (267)

Depth‐Dependence Changes in Soil Stoichiometry in China's Croplands Over the Past Four Decades

Advanced Science, EarlyView.
This study reveals depth‐dependent changes in soil C:N:P ratios across Chinese croplands over four decades. Changes in stoichiometry vary markedly between topsoil and subsoil, with initial soil C:N:P ratios playing a key role in determining their trajectories.
Xiaodong Sun, Zhenghu Zhou, Yiqi Luo, Qingzhu Gao, Hu Li, Shuo Liu, Minggang Xu, Yu'e Li, Andong Cai   +8 more
wiley   +1 more source

Viral Systemic Movement Is Enhanced by Alteration of a Structural Phloem Protein by the Insect Vector

Advanced Science, EarlyView.
Aphids release salivary protein GLD into plants, which induces ROS in the phloem. This leads to the intermolecular disulfide bonds formation among SEO proteins, promoting their transition from the dispersed state to the aggregated state. SEO can interact with CMV CP.
Huijuan Guo, Qingyun Shi, Xiaoyu Ling, Yuting Wu, Lin He, Danyang Li, Keyan Zhu‐Salzman, Yucheng Sun   +7 more
wiley   +1 more source

Harnessing extracellular vesicles from adipose-derived stem cells for the treatment of 4-vinylcyclohexene diepoxide-induced premature ovarian insufficiency

Stem Cell Research & Therapy
Background Premature ovarian insufficiency (POI) is a challenging condition with limited effective treatments. Adipose-derived stem cells (ADSCs) have demonstrated potential in tissue repair, and their extracellular vesicles (ADSC-EVs) show more safety ...
Yanquan Li, Feng Chen, Wei Zhao, Di Sun, Li Zhang, Rui Qiao, Qianhui Hu, Songmao Li, Boyuan Chen, Haixia Ding, Meiling Zhang, Qing Zhang, Fanghao Guo, Wen Li   +13 more
doaj   +1 more source

The male reproductive toxicity after 5-Fluorouracil exposure: DNA damage, oxidative stress, and mitochondrial dysfunction in vitro and in vivo

Ecotoxicology and Environmental Safety
5-Fluorouracil (5-FU), a chemotherapeutic drug used to treat a variety of cancers, can enter the environment through different routes, causing serious public health and environmental concerns.
Wenzheng Yuan, Guojie Ji, Xiaowei Shi, Zhibin Sun, Chenyan Liu, Yangyang Yu, Wenmi Li, Xiaoyi Wang, Huanhuan Hu   +8 more
doaj   +1 more source

Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans

Nature Communications, 2020
How maternal RNA clearance is regulated in human preimplantation embryos is unclear. Here, the authors show there is a potential correlation between maternal mRNA decay defects and early developmental arrest from in vitro fertilized human embryos ...
Qian-Qian Sha, Wei Zheng, Yun-Wen Wu, Sen Li, Lei Guo, Shuoping Zhang, Ge Lin, Xiang-Hong Ou, Heng-Yu Fan   +8 more
doaj   +1 more source

Regulation of [Ca2+]i oscillations and mitochondrial activity by various calcium transporters in mouse oocytes

Reproductive Biology and Endocrinology, 2020
Oocyte activation inefficiency is one of the reasons for female infertility and Ca2+ functions play a critical role in the regulation of oocyte activation.
Feng Wang, Ang Li, Tie-Gang Meng, Le-Yun Wang, Li-Juan Wang, Yi Hou, Heide Schatten, Qing-Yuan Sun, Xiang-Hong Ou   +8 more
doaj   +1 more source

Nociceptive Nerve‐Derived CGRP Exacerbates Uterine Fibrogenesis in Adenomyosis by Promoting CD140b+ CD146+ Fibroblast Differentiation

Advanced Science, EarlyView.
This study investigates adenomyosis fibrosis in relation to nociceptive nerves. Nociceptive nerve‐secreted CGRP promotes RAMP1hi CD140b+ CD146+ fibroblast differentiation into myofibroblasts through ERK activation, causing severe fibrosis. Rimegepant‐induced CGRP/RAMP1 signaling blockade alleviates fibrosis and restores fertility in a mouse model. This
Zi Ye, Anning Zhao, Xia Li, Yanqing Hao, Dong Huang, Jianmin Chen, Tiantian Li, Yangyang Dai, Wenchao Sun, Lie Ma, Songying Zhang, Liaobing Xin   +11 more
wiley   +1 more source

High‐Resolution Genomic Resources for Trait Mapping and Precision Breeding for Adzuki Bean (Vigna angularis)

Advanced Science, EarlyView.
This study establishes crucial genomic resources for adzuki bean, including a reference genome, variation map, and the AdzukiBeanAtlas toolkit. We identify key candidate genes (ANKRD50, NAC73, ANR1, NPF5.4) for important agronomic traits through Genome‐Wide Association Studies (GWAS).
Liangliang Hu, Xiaolei Wang, Yazhou Zhang, Vanika Garg, Xingxing Yuan, Renfeng Xue, Hongmei Zhou, Yanhua Chen, Weili Hu, Rutwik Barmukh, Rong Cao, Tianxiao Chen, Qiannan Song, Dan Gao, Gaoling Luo, Xu Zhu, Xin Jing, Suhua Wang, Caiju Li, Yunshan Wei, Weide Ge, Xin Chen, Lixia Wang, Rajeev K Varshney, Chengzhi Jiao, Xuzhen Cheng, Honglin Chen   +26 more
wiley   +1 more source

Comparative Cochlear Transcriptomics in Echolocating Bats and Mouse Reveals Hras as Protector Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Comparative cochlear transcriptomics of noise‐exposed bats (Miniopterus fuliginosus) and mice reveals bat‐specific protection mechanisms for noise‐induced hearing loss (NIHL), identifying Hras as a key hub regulator. Functional studies in mice show hair‐cell‐specific Hras overexpression significantly reduced hair‐cell damage and NIHL by activating the ...
Peng Chen, Chenhao Che, Lingjie Wu, Changjie Sun, Dongming Xu, Qinyang Hua, Yunzhong Zhang, Yi‐Quan Tang, Peng Shi, Shan Sun   +9 more
wiley   +1 more source

Stage‐Resolved Phosphoproteomic Landscape of Mouse Spermiogenesis Reveals Key Kinase Signaling in Sperm Morphogenesis

Advanced Science, EarlyView.
The quantitative proteomic and phosphoproteomic profiling reveals dynamic phosphorylation regulation of sperm morphogenesis. Kinase‐substrate phosphorylation network and phosphorylation module analysis, followed by in vivo knockdown and knockout analysis, identify TTBK2 and CSNK1G1 as key regulators of morphogenesis, including head, flagellar, and ...
Tianyu Zhu, Yan Zhu, Xinyi Jiang, Xiangzheng Zhang, Bing Wang, Yu Chen, Yichen Zhao, Yulian Wang, Qi Zhou, Zhongyan Han, Yaling Qi, Mengjiao Luo, Haixia Tu, Bingjie Hao, Mengmeng Gao, Jie Ren, Xin Zhou, Xingyu Zhang, Xu Chen, Haojie Li, Qian Huang, Chenghao Situ, Yueshuai Guo, Hui Zhu, Yan Li, Xuejiang Guo   +25 more
wiley   +1 more source