Results 91 to 100 of about 1,809,415 (347)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Frontiers in Physiology, 2014 Background: During caesarean section spinal anaesthesia may provoke maternal hypotension that we prevent by administration of phenylephrine and/or ephedrine.
Visti Torbjørn Foss +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Editorial – Potential risks of the SARS-related coronavirus 2 infection [COVID-19] in pregnancy [PDF]
CellR4, 2020 A. Sfakianaki +5 more
doaj +1 more source
Prevalence of erythrocyte alloimmunization in polytransfused patients [PDF]
Einstein (São Paulo), 2011 Objective: To determine the incidence and the rate of red blood cellalloimmunization in polytransfused patients. Methods: A polytransfusedpatient was defined as having received at least 6 units of red cellconcentrates during a 3-month period. The records
Roberto de Oliveira Cruz +6 more
doaj
The breakpoint of a large deletion causing hereditary persistence of fetal hemoglobin occurs within an erythroid DNA domain remote from the beta-globin gene cluster [PDF]
, 1989 EA Feingold, BG Forget
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Ultrasound in Obstetrics & Gynecology, 1993 Several publications continue to address the topic of screening for fetal congenital heart disease with widely differing results. The ideal timing and method of fetal heart scanning is still under debate. An abnormal fetal heart position may indicate abnormality, particularly of the great arteries. The management of several problems that present to the
openaire +3 more sources
What is fetal programming?: a lifetime health is under the control of in utero health
Obstetrics & Gynecology Science, 2017 The “Barker hypothesis” postulates that a number of organ structures and associated functions undergo programming during embryonic and fetal life, which determines the set point of physiological and metabolic responses that carry into adulthood.
E. Kwon, Y. J. Kim
semanticscholar +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source