Results 81 to 90 of about 1,809,415 (347)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Environmental Justice Index and adverse pregnancy outcomesAJOG Global Reports at a Glance

AJOG Global Reports
BACKGROUND: The Environmental Justice Index is a tool released by the Centers for Disease Control and Prevention that quantifies and ranks the environmental burden and social vulnerability of each census tract.
Jaclyn Del Pozzo, DO, Insaf Kouba, MD, Alejandro Alvarez, MPH, Tadhg O'Sullivan-Bakshi, Kaveri Krishnamoorthy, Matthew J. Blitz, MD, MBA   +5 more
doaj   +1 more source

Ontogeny of innate T lymphocytes - some innate lymphocytes are more innate then others

Frontiers in Immunology, 2014
Innate lymphocytes have recently received a lot of attention. However, there are different ideas about the definition of what is innate in lymphocytes. Lymphocytes without V(D)J-rearranged antigen receptors are now termed innate lymphoid cells (ILCs) and
David eVermijlen, Immo ePrinz
doaj   +1 more source

International estimated fetal weight standards of the INTERGROWTH‐21st Project

Ultrasound in Obstetrics and Gynecology, 2017
Estimated fetal weight (EFW) and fetal biometry are complementary measures used to screen for fetal growth disturbances. Our aim was to provide international EFW standards to complement the INTERGROWTH‐21st Fetal Growth Standards that are available for ...
J. Stirnemann, J. Villar, L. Salomon, E. Ohuma, P. Ruyan, D. Altman, F. Nosten, R. Craik, S. Munim, L. Cheikh Ismail, F. Barros, A. Lambert, S. Norris, M. Carvalho, Y. Jaffer, J. Noble, E. Bertino, M. Gravett, M. Purwar, C. Victora, R. Uauy, Z. Bhutta, S. Kennedy, A. Papageorghiou, M. Katz, M.K. Bhan, C. Garza, A. Langer, P.M. Rothwell, S. D. Weatherall, P. Lumbiganon, J. Rivera, F. Burton, C. Victora, M. Shorten, I. Blakey, D. Altman, S. Gu, L. Juodvirsiene, L. Hoch, C. Cosgrove, D. Reade, R. Miller, C. Condon, M. Mainwaring, E. S. Urias, L. Salomon, F. Al-Aamri, P. Gaglioti, N. Jacinta, S. Jaiswal, J. Noble, E. Olearo, M.G. Owende, S. Sohoni, L. Wang, Sumbal Zaidi, P. Chamberlain, D. Danelon, J. Dhami, C. Knight, S. Wanyonyi, C. Pace, V. Mkrtychyan, M. Buckle, W. Chumlea, F. Al-Habsi, A. Carter, M. Alija, J.M. Jimenez-Bustos, H. Liu, M. Luna, H. Knight, B. Monyepote, V. Carrara, I. Olivera, G. Deutsch, Z. Bhutta, E. Albernaz, B. Bhat, K. McCormick, V. Paul, V. Rajan, A. Wilkinson, R. Uauy, B. Eskenazi, A. Bradman, O. Burnham, L.A. Corra, H. Dolk, F. Farhi, D. Finkton, J. Golding, A. Matijasevich, T. de Wet, J.J. Zhang, A. Stein, M. Fernandes, A. Abubakar, J. Acedo, L. Aranzeta, D. Ibáñez, M. Kihara, E. de Leon, C. Newton, S. Savini, A. Soria-Frisch, J. Villar, K. Wulff, F. Barros, M. Domingues, S. Fonseca, A. Leston, A. Mitidieri, D. Mota, I. Sclowitz, MF da Silveira, R. Pang, Y. He, Y. Pan, Y. Shen, M. Wu, Q.Q. Wu, J.H. Wang, Y. Yuan, Y. Zhang, M. Purwar, A. Choudhary, S. Choudhary, S. Deshmukh, D. Dongaonkar, M. Ketkar, V. Khedikar, N. Kunnawar, C. Mahorkar, I. Mulik, K. Saboo, C. Shembekar, A. Singh, V. Taori, K. Tayade, A. Somani, E. Bertino, P. D. Nicola, M. Frigerio, G. Gilli, P. Gilli, M. Giolito, F. Giuliani, M. Oberto, L. Occhi, C. Rossi, I. Rovelli, F. Signorile, T. Todros, W. Stones, M. Carvalho, J. Kizidio, R. Ochieng, J. Shah, S. Vinayak, N. Musee, C. Kisiang'ani, D. Muninzwa, J. Kilonzo, J. Sande, J. Berkley, B. Kemp, H. Barsosio, S. Mwakio, H. Mwangudzah, V. Ngami, M. Salim, A. Seale, L. Walusuna, Y. Jaffer, J. Al-Abri, J. Al-Abduwani, F. Al-Habsi, H. Al-Lawatiya, B. Al-Rashidiya, W.K.S. Al-Zadjali, F. Juangco, M. Venkataraman, H. Al-Jabri, D. Yellappan, S. Munim, G. Zainab, I. Ahmed, D. Alam, A. Raza, R. Salam, S. Norris, Y. Guman, T. Lephoto, S. Macauley, L. Malgas, F. Nosten, N. Jackson, R. McGready, A. Min, VI Cararra, S. Wiladphaingern, S. Kennedy, L. C. Ismail, A. Lambert, S. Lloyd, R. Napolitano, E. Ohuma, A. Papageorghiou, B. Patel, F. Puglia, F. Roseman, S. Roseman, C. Ioannou, I. Sarris, S. Ash, M. Baricco, A. Capp, R. Craik, S. Hussein, A. Laister, T. Lewis, E. Maggiora, T. Norris, M. Sharps, A. Varalda, R. Carew, M. Gravett, C. Batiuk, M. Batra, S. Bornemeier, M. Dighe, K. Oas, W. Paulsene, D. Wilson, I. Frederick, H. Andersen, S. Abbott, A. Carter, H. Algren, D.A. Rocco, T. Sorensen, D. Enquobahrie, S. Waller   +244 more
semanticscholar   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Peritonite meconial como diagnóstico diferencial de ascite fetal: relato de caso Meconium peritonitis in the differential diagnosis of fetal ascites: a case report

Revista Brasileira de Ginecologia e Obstetrícia, 1999
Introdução: a peritonite meconial, como resultado da perfuração intestinal fetal, apresenta baixa incidência (1:30.000 nascimentos) e elevada mortalidade (em torno de 50%). Os achados ecográficos pré-natais incluem ascite e calcificações intra-abdominais.
Melania Maria Ramos de Amorim, Paulo Carvalho Vilela, Luiz Carlos Santos, Gilliatt Hanois Falbo Neto, Ozanil Cursino, Fernando Amaral, Karina Maria Azevedo Bitencourt   +6 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Transplanting FVIII/ET3-secreting cells in fetal sheep increases FVIII levels long-term without inducing immunity or toxicity [PDF]

, 2023
Martin Rodriguez, Brady Trevisan, Ritu M. Ramamurthy, Sunil George, Jonathan Diaz, Jordan D. Alexander, Diane Meares, Denise J. Schwahn, David R. Quilici, Jorge Figueroa, Michael D. Gautreaux, Andrew M. Farland, Anthony Atala, Christopher B. Doering, H. Trent Spencer, Christopher D. Porada, Graça Almeida‐Porada   +16 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Comparison of Histological Chorioamnionitis in Pre-Term Delivery with and without Pre-Term Rupture of Membrane

Advanced Biomedical Research
Background: Histological chorioamnionitis (HCA) is a histologic response to intra-uterine inflammation that is usually confirmed by pathology examination after pre-term delivery and characterized by acute granulocyte infiltration into the fetal-maternal ...
Zahra Shahshahan, Elahe Zarean, Samaneh Jahanfar, Pegah Hedayat   +3 more
doaj   +1 more source