Results 41 to 50 of about 40,451 (242)

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Case Report: Multimodality imaging of a bronchogenic cyst in the interatrial septum

Frontiers in Cardiovascular Medicine
Intracardiac bronchogenic cysts (IBCs) are very rare. To date, only a few cases of IBC have been reported in the literature. We report a case of a bronchogenic cyst that arose from the interatrial septum in a 42-year-old man who presented with symptoms ...
Ma Mingming, Zhao Yana, Chen Ran, Zhu Qingqing, Zhao Bowen   +4 more
doaj   +1 more source

Accuracy of Prenatal Diagnosis of Congenital Cardiac Malformations [PDF]

Revista Brasileira de Ginecologia e Obstetrícia
Objective To evaluate the accuracy of the diagnosis of fetal heart diseases obtained through ultrasound examinations performed during the prenatal period compared with the postnatal evaluation.
Diesa Oliveira Pinheiro, Bruna Boff Varisco, Marcelo Brandão da Silva, Rafaela Silva Duarte, Graciele Dequi Deliberali, Carlos Roberto Maia, Mirela Foresti Jiménez, Patrícia El Beitune   +7 more
doaj   +2 more sources

A Review Study on the Prenatal Diagnosis of Congenital Heart Disease Using Fetal Echocardiography [PDF]

Reviews in Clinical Medicine, 2018
Congenital heart defect (CHD) is the most common type of congenital malformation in live births with a wide and variable spectrum in each population. The prevalence of this malformation is reported to be 8 cases per 1,000 live births.
Hassan Mottaghi, Elahe Heidari, Shirin Sadat Ghiasi   +2 more
doaj   +1 more source

Wharton’s jelly or bone marrow mesenchymal stromal cells improve cardiac function following myocardial infarction for more than 32 weeks in a rat model: a preliminary report [PDF]

, 2013
The therapeutic effect of mesenchymal stromal cells (MSCs) following myocardial infarction (MI) is small. This may be due to differences in cellular sources and donor age, route of administration, in vitro cellular manipulations and the short time course
Borgarelli, Michele, Hageman, Karen S., Lutjemeier, Barbara, López, Yelica, Musch, Timothy I., Seshareddy, Kiran, Trevino, Elizabeth M., Weiss, Mark L.   +7 more
core   +2 more sources

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Epigenetic Down-Regulation of Sirt 1 via DNA Methylation and Oxidative Stress Signaling Contributes to the Gestational Diabetes Mellitus-Induced Fetal Programming of Heart Ischemia-Sensitive Phenotype in Late Life. [PDF]

, 2019
Rationale: The incidence of gestational diabetes mellitus (GDM) is increasing worldwide. However, whether and how GDM exposure induces fetal programming of adult cardiac dysfunctional phenotype, especially the underlying epigenetic molecular mechanisms ...
Chen, Zewen, Gong, Lei, Li, Yong, Liu, Bailin, Xiao, Daliao, Zhang, Lubo, Zhang, Peng, Zhuang, Jian   +7 more
core  

Cerebral autoregulation, brain injury, and the transitioning premature infant [PDF]

, 2017
Improvements in clinical management of the preterm infant have reduced the rates of the two most common forms of brain injury, such as severe intraventricular hemorrhage and white matter injury, both of which are contributory factors in the development ...
Mathur, Amit M, Vesoulis, Zachary A
core   +3 more sources

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Prenatal diagnosis of accessory mitral valve tissue in a fetus with persistent dysrhythmia

The Egyptian Heart Journal, 2022
Background Accessory mitral valve tissue (AMVT) is a rare congenital cardiac anomaly that mainly diagnosed in the first decade of life. However, asymptomatic cases may not be diagnosed even up to adulthood.
Mohammad Nasir Hematian, Shirin Torabi, Sedigheh Hantoushzadeh, Alireza Dehestani, Minoo Dadkhah, Reza Shabanian   +5 more
doaj   +1 more source