Results 51 to 60 of about 258,432 (294)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

IJCM_77A: Predictors of fetal growth restriction in preterm birth

Indian Journal of Community Medicine
Background: Fetal growth restriction (FGR) is defined as fetuses whose estimated fetal weight or abdominal circumference is below the 10th percentile for gestational age.
Ganesh, Suchetha S Rao, Prasanna Mithra, Santosh Rai, Keshava K Pai, Shraddha K Shetty, Sauda, K M Akshaya   +7 more
doaj   +1 more source

Placental Malaria-Associated Inflammation Disturbs the Insulin-like Growth Factor Axis of Fetal Growth Regulation [PDF]

, 2011
Background. The pathogenetic mechanisms of fetal growth restriction associated with placental malaria are largely unknown. We sought to determine whether placental malaria and related inflammation were associated with disturbances in the insulin-like ...
J. Umbers, Alexandra, Boeuf, Philippe, Clapham, Caroline, I. Stanisic, Danielle, Baiwog, Francesca, Mueller, Ivo, Siba, Peter, L. King, Christopher, G. Beeson, James, Glazier, Jocelyn, J. Rogerson, Stephen   +10 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Placental Malaria: From Infection to Malfunction [PDF]

, 2006
Malaria during pregnancy is a major factor in infant morbidity and mortality. In this issue of Cell Host and Microbe, Conroy et al. (2013) propose that C5a, a product of complement cascade activation, counteracts the placental vascular remodeling ...
Luciana Vieira de Moraes, Carlos Penha-Gonçalves, Avery, Conroy, Conroy, Duffy, Girardi, Head, Lucchi, Moraes, Rodrigues-Duarte, Salanti   +11 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Maternal inflammation at 0.7 gestation in ewes leads to intrauterine growth restriction and impaired glucose metabolism in offspring at 30 d of age [PDF]

, 2019
Fetal programming associated with intrauterine growth restriction (IUGR) leads to lifelong deficits in growth and metabolic function (Hales and Barker, 2013).
Beard, Joslyn K., Beede, Kristin A., Cadaret, Caitlin N., Gibbs, Rachel L., Petersen, Jessica L., Posont, Robert J., Swanson, Rebecca M., Yates, Dustin T.   +7 more
core   +1 more source

Influence of intergenerational in utero parental energy and nutrient restriction on offspring growth in rural Gambia. [PDF]

, 2017
The prenatal environment can alter an individual's developmental trajectory with long-lasting effects on health. Animal models demonstrate that the impact of the early life environment extends to subsequent generations, but there is a paucity of data ...
Eriksen, Kamilla G, Fulford, Anthony JC, Prentice, Andrew M, Radford, Elizabeth J, Silver, Matt J, Wegmüller, Rita   +5 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Preeclampsia is associated with compromized maternal synthesis of long chain polyunsaturated fatty acids leading to offspring deficiency [PDF]

, 2012
Obesity and excessive lipolysis are implicated in preeclampsia (PE). Intrauterine growth restriction is associated with low maternal body mass index and decreased lipolysis.
Brown, E.A., Freeman, D.J., Greer, I.A., Hodson, L., Huda, S.S., Jordan, F., Mackay, V.A., Martin, I., McKenna, L.A., Meyer, B.J., Stewart, F.M., Tham, K.   +11 more
core   +2 more sources