Results 61 to 70 of about 258,432 (294)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Early onset fetal growth restriction [PDF]

Best Practice & Research Clinical Obstetrics & Gynaecology, 2017
Fetal growth restriction remains a challenging entity with significant variations in clinical practice around the world. The different etiopathogenesis of early and late fetal growth restriction with their distinct progression of fetal severity and outcomes, compounded by doctors and patient anxiety adds to the quandary involving its management.
Aamod Nawathe, Christoph Lees
openaire   +4 more sources

Aspirin plus calcium supplementation to prevent superimposed preeclampsia: a randomized trial [PDF]

, 2014
Preeclampsia is an important cause of maternal and perinatal morbidity and mortality. Previous studies have tested calcium supplementation and aspirin separately to reduce the incidence of preeclampsia but not the effects of combined supplementation. The
Atallah, Álvaro Nagib, Dos Santos, G.m.s., Kulay Jr, L., Sass, Nelson, Souza, E.v., Torloni, Maria Regina   +5 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Umbillical venous volume inflow and liver size in normal and abnormal fetal development [PDF]

, 2003
In this thesis the following research objectives were addressed: To calculate umbilical venous volume flow from cross-sectional area and flow velocity measurements with emphasis on: (i) the reproducibility of component measurements; (ii) normal and ...
Boito, S.M.
core  

Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR [PDF]

, 2019
Intrauterine growth restriction (IUGR) is a condition whereby a fetus is unable to achieve its genetically determined potential size. IUGR is a global health challenge due to high mortality and morbidity amongst affected neonates.
Dechend, Ralf, Haase, Nadine, Herse, Florian, Kräker, Kristin, Langmia, Immaculate M., Schütte, Till, Weiss, Sara E.   +6 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Mitochondrial dysfunction-induced high hCG associated with development of fetal growth restriction and pre-eclampsia with fetal growth restriction

Scientific Reports, 2022
Fetal growth restriction (FGR) and pre-eclampsia with fetal growth restriction (PE/FGR) are high-risk perinatal diseases that may involve high levels of human chorionic gonadotropin (hCG) and mitochondrial dysfunction.
Ryo Kiyokoba, Takeshi Uchiumi, Mikako Yagi, Takahiro Toshima, Shigehiro Tsukahara, Yasuyuki Fujita, Kiyoko Kato, Dongchon Kang   +7 more
doaj   +1 more source

Prenatal depression restricts fetal growth [PDF]

Early Human Development, 2009
To identify whether prenatal depression is a risk factor for fetal growth restriction.Midgestation (18-20 weeks GA) estimated fetal weight and urine cortisol and birthweight and gestational age at birth data were collected on a sample of 40 depressed and 40 non-depressed women. Estimated fetal weight and birthweight data were then used to compute fetal
Miguel A, Diego, Tiffany, Field, Maria, Hernandez-Reif, Saul, Schanberg, Cynthia, Kuhn, Victor Hugo, Gonzalez-Quintero   +5 more
openaire   +2 more sources

Longitudinal study of computerised cardiotocography in early fetal growth restriction. [PDF]

, 2016
OBJECTIVES: To explore if in early fetal growth restriction (FGR) the longitudinal pattern of short-term fetal heart rate (FHR) variation (STV) can be used for identifying imminent fetal distress and if abnormalities of FHR registration associate with ...
Aktas, A. (Ayse), Arabin, B. (Birgit), Bilardo, C.M. (Caterina Maddalena), Borgione, S. (Silvia), Brezinka, C.A. (Christoph), Calvert, S. (Sandra), Chaoui, R. (R.), Cornette, J.M.J. (Jerome M. J.), Derks, J.B. (Jan), Diehl, T. (Thilo), Diemert, A. (Anke), Duvekot, J.J. (Hans), Eyck, J. (Jim) van, Ferrazzi, E. (Enrico), Fratelli, N. (N.), Frusca, T. (T.), Ganzevoort, W. (Wessel), Hecher, K. (Kurt), Johnson, S. (Samantha), Lees, C. (Christoph), Lobmaier, S. (Silvia), Lopriore, E., Mansi, G. (Giuseppina), Marlow, N. (Neil), Martelli, P. (Paola), Martinelli, P. (Pasquale), Maso, G. (G.), Maurer-Fellbaum, U. (Ute), Missfelder-Lobos, H. (H.), Moore, T. (Tamanna), Napolitano, R. (Raffaele), Oberto, M. (M.), Oepkes, D., Ogge, G. (G.), Ostermayer, E. (Eva), Papageorghiou, A.T. (A.), Post, J.A.M. (Joris) van der, Prefumo, F. (F.), Preston, L. (Lucy), Raimondi, F. (Francesco), Reiss, I.K.M. (Irwin), Rigano, S. (Serena), Scheepers, H.C.J. (Hubertina), Schlembach, D. (Dietmar), Schneider, K.T.M. (K. T.M.), Schuit, E. (Ewoud), Skabar, A. (Aldo), Spaanderman, M.E.A., Thilaganathan, B. (Baskaran), Todros, T. (Tullia), Tollenaer, S.M. (S.) de, Valcamonico, A. (Adriana), Van Charante, N.M. (Nico Mensing), van Haastert, I.-L. (Inge-Lot), Visser, G.H. (Gerhard Henk), Wassenaer-Leemhuis, A.G. (Aleid) van, Weisglas–Kuperus, N. (Nynke), Wolf, H. (Hans Uwe), Zimmermann, A. (Andrea)   +58 more
core   +6 more sources