Results 61 to 70 of about 266,924 (341)
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Determinants of Growth, Adiposity and Bone Mass in Early Life [PDF]
, 2016 Environmental influences during fetal life and early infancy have been suggested to influence body composition throughout the life-course. Especially poor fetal nutrition and fetal growth restriction have been designated important risk factors for ...
Heppe, D.H.M. (Denise)
core
Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR [PDF]
, 2019 Intrauterine growth restriction (IUGR) is a condition whereby a fetus is unable to achieve its genetically determined potential size. IUGR is a global health challenge due to high mortality and morbidity amongst affected neonates.
Dechend, Ralf +6 more
core +2 more sources
Early onset fetal growth restriction [PDF]
Best Practice & Research Clinical Obstetrics & Gynaecology, 2017 Fetal growth restriction remains a challenging entity with significant variations in clinical practice around the world. The different etiopathogenesis of early and late fetal growth restriction with their distinct progression of fetal severity and outcomes, compounded by doctors and patient anxiety adds to the quandary involving its management.
Aamod Nawathe, Christoph Lees
openaire +4 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Scientific Reports, 2022 Fetal growth restriction (FGR) and pre-eclampsia with fetal growth restriction (PE/FGR) are high-risk perinatal diseases that may involve high levels of human chorionic gonadotropin (hCG) and mitochondrial dysfunction.
Ryo Kiyokoba +7 more
doaj +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Umbillical venous volume inflow and liver size in normal and abnormal fetal development [PDF]
, 2003 In this thesis the following research objectives were addressed: To calculate umbilical venous volume flow from cross-sectional area and flow velocity measurements with emphasis on: (i) the reproducibility of component measurements; (ii) normal and ...
Boito, S.M.
core
The impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model of fetal growth restriction. [PDF]
, 2016 Enhancing placental insulin-like growth factor (IGF) availability appears to be an attractive strategy for improving outcomes in fetal growth restriction (FGR).
Aplin, JD +5 more
core +2 more sources
Effect of Vitamin D Supplementation on the Fetal Growth Rate in Pregnancy Complicated by Fetal Growth Restriction [PDF]
, 2022 Karolina Jakubiec-Wisniewska +2 more
openalex +1 more source