Results 101 to 110 of about 2,022,294 (304)

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

ST analysis of fetal electrocardiography in labor

, 2011
Since its introduction more than 40 years ago, electronic fetal monitoring has become widely used for intrapartum surveillance to determine fetal wellbeing in labor.
I. Amer-Wåhlin, K. Maršál, Marsal, K, Amer-Wåhlin, Isis, Marsal, Karel, Amer-Wahlin, I, Amer-Wåhlin, Isis,, Marsal, Karel,, Lund University.   +8 more
core   +2 more sources

Fetal MRI of the heart and brain in congenital heart disease

, 2023
Antenatal assessment of congenital heart disease and associated anomalies by ultrasound has improved perinatal care. Fetal cardiovascular MRI and fetal brain MRI are rapidly evolving for fetal diagnostic testing of congenital heart disease.
Moerdijk, Anouk S., Grotenhuis, Heynric B., Alderliesten, Thomas, van Ooij, Pim, van Ooijen, Inge M., Anouk S Moerdijk, A Hirsch, E Pajkrt, Klein, W.M., Moerdijk, A.S., MN Bekker, Thomas Alderliesten, S Frerich, EM Schrauben, HJ Lamb, Nathalie HP Claessens, M Nijman, JMJ Cornette, ATJI Go, Grotenhuis, H.B., MJNL Benders, S Gommers, Ooijen, I.M. van, D Charisopoulou, TJ Steenhuis, JMPJ Breur, TP Willems, RN Planken, LM Geerdink, Inge M van Ooijen, J van Schuppen, GG van Iperen, S-A Clur, Claessens, Nathalie HP, Alderliesten, T., Pim van Ooij, WYR Vanagt, Claessens, N.H., Z Fejzic, WM Klein, WA Helbing, RJ Holtackers, I Witters, IM van Beynum, H ter Heide, MD van Gaalen, GJ Krings, Heynric B Grotenhuis, AE Bohte, MTM Franssen, Ooij, P. van   +50 more
core   +1 more source

Vitamin C‐Induced Photo‐Redox Threshold Enables High‐Fidelity Volumetric Printing of Collagen

Advanced Materials, EarlyView.
Tomographic volumetric printing (TVP) of native proteins is limited by uncontrolled background crosslinking. Here, vitamin C is introduced as a biocompatible redox regulator to establish a tunable nonlinear polymerization threshold response for TVP.
Bin Wang, Amelia Hasenauer, Kristian Ivkovic, Ann‐Sophie Frind, David Fercher, Marcy Zenobi‐Wong   +5 more
wiley   +1 more source

Generation of a PDK-1 knockout human embryonic stem cell line by CRISPR/(WAe009-A-2K) Cas9 editing

Stem Cell Research
Pyruvate Dehydrogenase Kinase1 (PDK1) belongs to the family of kinases, regulates diverse metabolic processes. PDK1 is a susceptibility locus for heart failure via thinning of ventricle walls, and enlarged atria and ventricles.
Amina Saleem, Mingyu Wei, Muhammad Khawar Abbas, Siyao Zhang, Jiaqi Fan, Yang Xian, Hongfeng Jiang   +6 more
doaj   +1 more source

Unrecognized maternal heart rate artefact in cases of perinatal mortality reported to the United States Food and Drug Administration from 2009 to 2019: a critical patient safety issue

BMC Pregnancy and Childbirth, 2019
Background Maternal heart rate artefact is a signal processing error whereby the fetal heart rate is masked by the maternal pulse, potentially leading to danger by failure to recognize an abnormal fetal heart rate or a pre-existing fetal death.
Daniel J. Kiely, Lawrence W. Oppenheimer, James C. Dornan   +2 more
doaj   +1 more source

Bilayered PEDOT:PSS–Collagen Scaffolds as Functional Architectures for Tissue Engineering

Advanced Materials Interfaces, EarlyView.
A bilayered scaffold integrates collagen and PEDOT:PSS as distinct yet interconnected 3D matrices, preserving their fibrillar and conductive characteristics. Spatial compartmentalization enables independent tailoring of each domain while maintaining mechanical stability and compatibility with electrochemical monitoring, providing a multifunctional ...
Rasha Nasser, Jiranuwat Sapudom, Sotiris Psilodimitrakopoulos, Emmanuel Stratakis, Jeremy Teo, Vincent Chan, Charalampos Pitsalidis   +6 more
wiley   +1 more source

Evaluation of fetal cardiac morphology and function in hypertensive disorders of pregnancy using Fetal HQ technology combined with uterine artery ultrasound parameters

Frontiers in Cardiovascular Medicine
ObjectiveHypertensive disorders of pregnancy (HDP) significantly affect both maternal and fetal health, with uterine artery hemodynamic parameters playing a critical role in assessing fetal well-being, though they do not provide early insights into fetal
Lu Wang, Xinghui Fu, Xiaoyu Ren, Yu Guo, Haixia Zhou, Hongli Yue, Chunjing Song, Danhua Zhang, Gang Li, Wenrui Li, Pengjie Zhang   +10 more
doaj   +1 more source

Characterization of fetal heart transplant.

, 2012
A: Typical fetal heart (arrows) on the surface of a recipient kidney 10 months after transplantation into the kidney capsule. B: Cross section of this fetal heart co-stained with vWF (green), TnT (red) and DAPI (blue).
Piradeep Suntharalingam (182402), David E. Harrison (182410), Eric Y. Zhang (182395), Lei Ye (104076), Jianyi Zhang (104103), Qiang Xiong (182400), Xiaohong Wang (93777), C. Michael Astle (182407)   +7 more
core   +1 more source

Microfluidic Droplet Plate Preserving Single Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Morphology and Function

Advanced Materials Technologies, EarlyView.
We introduce a novel method combining microfluidics, optogenetics, and human induced pluripotent stem cell (iPSC) technology to encapsulate single iPSC‐derived cardiomyocytes (iPSC‐CMs) in an optimal environment for functional characterization. This method enables direct genotype‐phenotype correlation for genetic studies and high‐throughput screening ...
Xiao‐Ting Wang, Rachel P. White, Yashasvi Tharani, Michael A. Finocchiaro, Leona M. Ripple, Maksymilian Prondzynski, Tania Konry, Vassilios J. Bezzerides   +7 more
wiley   +1 more source