Results 91 to 100 of about 832,435 (375)

Tumor Microenvironment‐responsive Nanocatalyst for Targeted Chemodynamic Cancer Therapy

Advanced Healthcare Materials, EarlyView.
An Tumor microenvironment‐responsive nanocatalyst system composed of PLGA‐encapsulated Ca–Fe peroxide and polyarginine enables sustainable Fenton reaction in tumors. Low levels of H2O2 (50–100 µm) initiate the nanoparticle degradation, while polyarginine‐derived nitric oxide accelerates Fe3+ reduction, leading to self‐amplifying •OH generation for ...
Jun Ma, Jingjing Qiu, Shiren Wang
wiley   +1 more source

Improved Fetal Hemoglobin With mTOR Inhibitor–Based Immunosuppression in a Kidney Transplant Recipient With Sickle Cell Disease

American Journal of Transplantation, 2017
Fetal hemoglobin induction is a key point in the management of sickle cell disease (SCD). We report the case of a kidney transplant recipient with SCD who was treated with everolimus, a mammalian target of rapamycin inhibitor.
N. Gaudré, P. Cougoul, P. Bartolucci, G. Dörr, A. Bura-Rivière, N. Kamar, A. Del Bello   +6 more
semanticscholar   +1 more source

Antitumoral Efficacy of AuNRs‐Laden ECFCs In Vitro and In Vivo: Decoding the Heat and Rays Combo Treatment in Breast Cancer and Melanoma Cells

Advanced Healthcare Materials, EarlyView.
Endothelial Colony Forming Cells (ECFCs) acted as cellular cyborgs, stealthily transporting gold nanorods (AuNRs) into tumors to enable targeted near‐infrared (NIR) hyperthermia combined with radiotherapy. This approach triggers ferroptosis in melanoma and inhibits autophagy in breast cancer, revealing a tumor‐specific response to nanomaterial‐assisted
Cecilia Anceschi, Francesca Scavone, Paolo Armanetti, Luca Menichetti, Claudia Catarinicchia, Claudia Borri, Fulvio Ratto, Filippo Micheletti, Noemi Formica, Jessica Ruzzolini, Elena Frediani, Anastasia Chillà, Francesca Margheri, Mirko Severi, Rita Traversi, Patrizia Nardini, Daniele Guasti, Mario Del Rosso, Tommaso Del Rosso, Lisa Giovanelli, Cinzia Talamonti, Monica Mangoni, Isacco Desideri, Silvia Burchielli, Fabiola Pajar, Gabriella Fibbi, Anna Laurenzana   +26 more
wiley   +1 more source

A common signaling pathway is activated in erythroid cells expressing high levels of fetal hemoglobin: a potential role for cAMP-elevating agents in β-globin disorders

Journal of Blood Medicine, 2013
Tohru Ikuta,1 Yuichi Kuroyanagi,1 Nadine Odo,1 Siyang Liu21Department of Anesthesiology and Perioperative Medicine, 2Department of Physiology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USABackground: Although erythroid cells ...
Ikuta T, Kuroyanagi Y, Odo N, Liu S
doaj  

Diagnóstico não invasivo da anemia fetal pela medida do pico de velocidade sistólica na dopplervelocimetria da artéria cerebral média Noninvasive fetal anemia diagnosis by middle cerebral artery peak systolic velocity waveform measurement

Revista Brasileira de Ginecologia e Obstetrícia, 2004
OBJETIVO: avaliar se existe associação entre a medida do pico de velocidade sistólica (PVS) na dopplervelocimetria da artéria cerebral média (ACM) e a concentração de hemoglobina fetal e determinar a sua capacidade diagnóstica.
Marcos Roberto Taveira, Antônio Carlos Vieira Cabral, Henrique Vítor Leite, Isabela Gomes de Melo, Ana Paula Brum de Miranda Lopes   +4 more
doaj   +1 more source

Optimal villi density for maximal oxygen uptake in the human placenta

, 2015
We present a stream-tube model of oxygen exchange inside a human placenta functional unit (a placentone). The effect of villi density on oxygen transfer efficiency is assessed by numerically solving the diffusion-convection equation in a 2D+1D geometry ...
Brownbill, P., Filoche, M., Grebenkov, D. S., Salafia, C., Serov, A. S.   +4 more
core   +1 more source

Upconversion Nanoparticle‐Covalent Organic Framework Core–shell Particles as Therapeutic Microrobots Trackable With Optoacoustic Imaging

Advanced Materials, EarlyView.
Upconversion nanoparticle‐covalent organic framework core–shell particles provide enhanced contrast for optoacoustic imaging by leveraging the optical absorption of upconversion luminescence within the covalent organic framework matrix. Beyond their role as contrast agents, these particles enable customizable therapeutic agent loading and release, as ...
Dong Wook Kim, Paul Wrede, Andrés Rodríguez‐Camargo, Yi Chen, Nihal Olcay Dogan, Chaim Glück, Bettina V. Lotsch, Daniel Razansky, Metin Sitti   +8 more
wiley   +1 more source

Studies on Human γ-globin Gene Regulation: Transcription Factors in a Rubik’s Cube [PDF]

, 2009
The red blood cell is one of the most important blood cells in the human body. Hemoglobin is the major protein in the red blood cell, and functions as a gas transporter (oxygen and carbon dioxide) to all parts of the body. Changes in the structure or the
Papadopoulos, P. (Petros)
core  

Conference scene : Golden Helix Pharmacogenomics Days : educational activities on pharmacogenomics and personalized medicine [PDF]

, 2012
The Golden Helix Pharmacogenomics Days are high-profile international educational scientific meetings discussing pharmacogenomics and personalized medicine.
Borg, Joseph J., Fenech, Anthony G., Grech, Godfrey, Patrinos, George P., Severino, Giovanni, Squassina, Alessio   +5 more
core   +2 more sources

Magnetically Controlled Reversible Photomagnetic Nanoactuators for Dynamic Contrast Enhancement in Optical Coherence Tomography

Advanced Materials, EarlyView.
Photomagnetic nanoactuators with ≈90% scattering efficiency in the second near‐infrared window are demonstrated to exhibit magnetic field‐controlled modulation of optical scattering and optical coherence tomography signals. These nanoactuators are reversibly assembled and disassembled under the external magnetic field modulation, enabling enhanced ...
Myeongsoo Kim, Samuel M. A. Morais, Anamik Jhunjhunwala, Shivashankar Subramanian, Paul S. Pelkowski, Stanislav Y. Emelianov   +5 more
wiley   +1 more source