Results 101 to 110 of about 821,341 (299)
Molecular Therapy: Methods & Clinical Development, 2019 Elements within the γ-hemoglobin promoters (HBG1 and HBG2) function to bind transcription complexes that mediate repression of fetal hemoglobin expression. Sickle cell disease (SCD) subjects with a 13-bp deletion in the HBG1 promoter exhibit a clinically
Christopher T. Lux +13 more
doaj
Hemoglobin Non-equilibrium Oxygen Dissociation Curve [PDF]
arXiv, 2019 Abnormal hemoglobins can have major consequences for tissue delivery of oxygen. Correct diagnosis of hemoglobinopathies with altered oxygen affinity requires a determination of hemoglobin oxygen dissociation curve (ODC), which relates the hemoglobin oxygen saturation to the partial pressure of oxygen in the blood.
arxiv
Immunological Determination of Human Fetal Hemoglobin [PDF]
Clinical Chemistry and Laboratory Medicine, 1973 Peer ...
openaire +3 more sources
Transcriptional Repressors of Fetal Globin Genes as Novel Therapeutic Targets in Beta-Thalassemia [PDF]
, 2020 During development the human β-globin gene cluster undergoes two switching processes at the embryo-fetal and fetal-adult stages, respectively, involving changes in chromatin remodeling and in transcriptional regulatory networks. In particular, during the
Bianco, Alessandra Lo +8 more
core +2 more sources
Association of HMIP1 C-893A polymorphism and disease severity in patients with sickle cell anemia
Hematology, Transfusion and Cell Therapy, 2021 Introduction: Sickle cell anemia (SCA) is a Mendelian disorder with a heterogeneous clinical course. The reasons for this phenotypic diversity are not entirely established, but it is known that high fetal hemoglobin levels lead to a milder course of the ...
Diego A. Pereira-Martins +9 more
doaj
Premarital screening of 466 Mediterranean women for serum ferritin, vitamin B12, and folate concentrations [PDF]
, 2015 Background/aim: Iron, folate, and vitamin B12 serum levels are closely related with dietary habits and have an essential role in the healthy development of a fetus.
Demirciler, İ. +5 more
core +1 more source
Comment on "Twisted Protein Aggregates and Disease: The Stability of Sickle Hemoglobin Fibers" [PDF]
arXiv, 2010 Aggregates of twisted protein fibers, such as sickle hemoglobin and actin, are important examples of biopolymers in which elastic interactions play a crucial role in determining the (metastable) bundle radii. Here, we present a corrected version of analysis on the stability of sickle hemoglobin fibers using the classic nucleation theory.
arxiv
BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations.
Journal of Clinical Investigation, 2015 A transition from fetal hemoglobin (HbF) to adult hemoglobin (HbA) normally occurs within a few months after birth. Increased production of HbF after this period of infancy ameliorates clinical symptoms of the major disorders of adult β-hemoglobin: β ...
Anindita Basak +14 more
semanticscholar +1 more source
Study of Pregnancy Outcome in E-Beta Thalassaemia Mothers [PDF]
, 2009 Forty eight E-Beta thalassaemia patients were studied in NRS Medical College, Kolkata, West Bengal during the period from 2000-2006. In all patients Hb% ranged from 5.2g% - 9.6g%.
Bhattacharyaya, Maitryaee +1 more
core +1 more source
Localised IR spectroscopy of hemoglobin [PDF]
arXiv, 2010 IR absorption spectroscopy of hemoglobin was performed using an IR optical parametric oscillator laser and a commercial atomic force microscope in a novel experimental arrangement based on the use of a bottom-up excitation alignment. This experimental approach enables detection of protein samples with a resolution that is much higher than that of ...
arxiv