Results 191 to 200 of about 72,054 (299)

Enhanced induction of fetal hemoglobin by the combination of decitabine with RN-1 in β-thalassemia/HbE erythroid progenitor cells. [PDF]

Mol Med
Nualkaew T, Pongpaksupasin P, Munkongdee T, Buasuwan N, Paiboonsukwong K, Sripichai O, Engel JD, Hongeng S, Fucharoen S, Jearawiriyapaisarn N.   +9 more
europepmc   +1 more source

Rare vasculitis types and obstetric and neonatal outcomes – A population‐based study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Vasculitis is an infrequent pathology among reproductive‐aged women. While data exists regarding pregnancy outcomes in the more common vasculitis subtypes, data is limited regarding these outcomes in rare vasculitis subtypes. We aimed to compare pregnancy and perinatal outcomes between women who suffered from rare types of vasculitis
Uri Amikam, Ahmad Badeghiesh, Haitham Baghlaf, Richard Brown, Michael H. Dahan   +4 more
wiley   +1 more source

Severe maternal and neonatal morbidity or mortality in forceps versus cesarean birth in the second stage of labor: A systematic review and meta‐analysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Approximately one in four first‐time mothers reach the second stage of labor but cannot have a spontaneous vaginal birth, necessitating an intervention such as forceps to facilitate birth. Objective This study synthesizes evidence comparing severe maternal morbidity (SMM) and neonatal morbidity or mortality (SNMM) following forceps ...
Irina I. Oltean, Abirami Kirubarajan, Giulia M. Muraca   +2 more
wiley   +1 more source

Timing, indications, and outcomes of termination of pregnancy after 20 weeks: A retrospective single‐center cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study evaluate the indications, timing, and maternal outcomes of termination of pregnancy (TOP) after 20 weeks of gestation. Methods This single‐center retrospective cohort study included all TOP cases performed after 20 weeks between January 2020 and December 2025 in a tertiary referral center.
Erdem Fadiloglu, Murat Cagan, Mert Eyupoglu, Zeynab Mamtiyeva, Rahiba Salim, Ozgur Deren   +5 more
wiley   +1 more source

Downregulation of ZBTB7A/LRF increases fetal hemoglobin expression in β⁰-thalassemia/hemoglobin E erythroid cells. [PDF]

Sci Rep
Chumchuen S, Pornsukjantra T, Innachai P, Khamphikham P, Wongborisuth C, Anurathapan U, Songdej D, Sripichai O, Tangprasittipap A, Hongeng S.   +9 more
europepmc   +1 more source

Maternal outcomes according to fetal head station at diagnosis of the second stage of labor

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study determines the association between fetal head station (FHS) at the diagnosis of the second stage of labor and adverse maternal outcomes. Methods This retrospective cohort study was conducted at a single university‐affiliated tertiary medical center from 2011 to 2023, including singleton vertex deliveries at ≥ 37 weeks of ...
Itamar Gilboa, Daniel Gabbai, Anat Lavie, Or Rosentveig, Yoav Baruch, Yariv Yogev, Emmanuel Attali   +6 more
wiley   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, EarlyView.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Molecular spectrum and carrier frequency of deletional hereditary persistence of fetal hemoglobin and delta-beta thalassemia in Malaysia. [PDF]

Blood Res
Abdul Hamid FS, Md Noor S, Lai MI, Mohd Bahari SK, Esa E, Mohd Sahid EN, Mohd Yasin N, Mat Yusoff Y.   +7 more
europepmc   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Total ginsenosides enhance γ-globin expression and fetal hemoglobin production in β-thalassemia models. [PDF]

Front Pharmacol
Cai D, Chan Y, He G, Kong Y, Cai A, Guo Y, Zhu B.   +6 more
europepmc   +1 more source