Results 201 to 210 of about 72,054 (299)

Integrated one‐pot CRISPR‐Cas detection: Addressing strategies and future prospects

Interdisciplinary Medicine, EarlyView.
Integrated one‐pot CRISPR‐Cas detection significantly simplifies workflows, reduces cross‐contamination risks, and shortens turnaround times, making it highly suitable for point‐of‐care testing (POCT) and resource‐limited settings. Key challenges include system compatibility issues between Cas proteins and isothermal amplification, limited multiplexing
Jian Zhou, Xuemei Ren, Yingjie Ren, Ruiping Wu, Ruiman Geng, Le Chen, Zhuo Li   +6 more
wiley   +1 more source

Health Biomarkers of Pesticide Exposure in Rural Populations of Santa Fe, Argentina: Oxidative Stress and Genotoxicity

Journal of Applied Toxicology, EarlyView.
ABSTRACT The present study aimed to quantify pesticide residues in environmental matrices and plasma and to evaluate their potential effects on oxidative stress and DNA damage in rural populations of Santa Fe province. Soil and rainwater samples were collected, and biological samples and semistructured surveys were obtained from volunteers in three ...
María Priscila Dechiara, Carlina Leila Colussi, Lucía Magdalena Odetti, Damián Marino, María Fernanda Simoniello   +4 more
wiley   +1 more source

Fetal Cardiovascular Profile Score (CVPs) in Fetal Anemia, Using Fetal Hemoglobin Bart's Disease at Mid-Pregnancy as a Study Model. [PDF]

Diagnostics (Basel)
Hantrakun P, Srisupundit K, Tongsong T.
europepmc   +1 more source

Safety Assessment and Hypoglycemic Effect of Moringa oleifera Lam. Seed Lectin (WSMoL) in Alloxan‐Induced Diabetic Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos, Matheus Cavalcanti de Barros, Cleidiane Silva Vieira de Souza, Ryan Cristian da Silva, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia, Fernanda das Chagas Ângelo Mendes Tenório, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Robson Raion de Vasconcelos Alves, Patrícia Maria Guedes Paiva   +10 more
wiley   +1 more source

Selective AMPKβ1 activation induces fetal hemoglobin in human erythroid cells and sickle cell mice via the noncanonical NRF2 pathway. [PDF]

Sci Adv
Hara Y, Lemgart VT, Lessard S, Mercadante CJ, Ribeil JA, Hicks A, Rimmele P, Light DR.   +7 more
europepmc   +1 more source

Resolving a Complex Neonatal Phenotype by Rapid Trio Whole‐Genome Sequencing: A De Novo 11q14.3–q22.3 Deletion and a Splicing‐Altering Synonymous ANK1 Variant

Journal of Clinical Laboratory Analysis, EarlyView.
Clinical utility of trio WGS and time metrics in a neonate with congenital anomalies and hemolytic anemia. ABSTRACT Background Neonates with complex and evolving phenotypes often lack sufficiently specific clinical features to guide targeted genetic testing.
Hyun‐Woo Lee, Ja‐Hyun Jang, Beom Hee Lee, Hee‐Jeong Youk, Eun Sun Kim, Kee Hyun Cho, Yun Sil Chang, Heui Seung Jo, Mi‐Ae Jang   +8 more
wiley   +1 more source

Fetal Hemoglobin Decrease During Voxelotor Treatment. [PDF]

Eur J Haematol
De Luna G, Habibi A, Moutereau S, Martino S, Alhamrouni J, Morel C, Pelinski Y, Zaouali Y, Galactéros F, Bartolucci P.   +9 more
europepmc   +1 more source

The microchromatographic estimation of fetal hemoglobin levels in hereditary persistence of fetal hemoglobin.

Clinical Chemistry, 1984
P Mohorn, A E Neely, D Y Parnell, C R Baisden, M H Jonah, J S Krauss   +5 more
openaire   +1 more source

Elevated Hemoglobin A2: A Molecular Revisited, and Implications to β‐Thalassemia Screening

Journal of Clinical Laboratory Analysis, EarlyView.
In Thailand, the Hb A2 cut‐off value for β‐thalassemia carrier has been changed from 4.0% to 3.6% since 2015. We examined the molecular basis of β‐thalassemia in a large cohort of Thai subjects with this change. The molecular basis of β‐thalassemia was updated, and a change in the Hb A2 cut‐off can alter this spectrum.
Kritsada Singha, Anupong Pansuwan, Hataichanok Srivorakun, Attawut Chaibunruang, Supawadee Yamsri, Wanicha Tepakhan, Kanokwan Sanchaisuriya, Goonnapa Fucharoen, Supan Fucharoen   +8 more
wiley   +1 more source

Dissecting the epigenetic regulation of the fetal hemoglobin genes to unravel a novel therapeutic approach for β-hemoglobinopathies. [PDF]

Nucleic Acids Res
Amistadi S, Fontana L, Magnoni C, Felix T, Charvin MK, Martinucci P, Gautier C, Greau L, Bessières B, Antoniou P, Romano O, Allemand E, Mussolino C, Miccio A.   +13 more
europepmc   +1 more source