Results 201 to 210 of about 1,339,121 (337)

LDB1 represses fetal hemoglobin expression by enhancing BCL11A transcription. [PDF]

Redox Biol
Park SW, Choi CY, Park IB, Kang SJ, Lee HJ, Kim JI, Bae J, Geum D, Cheon YP, Chun T.   +9 more
europepmc   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Targeted protein degradation for fetal hemoglobin induction: a new paradigm in β-hemoglobinopathy therapy. [PDF]

Biomark Res
Arji S, Shen Z, Welch S, ElMahdaoui F, Bahadur A, Lee E, Lee H, Wu SP, Konshina E, Ayubali B, Tenen D, Chai L, Liu J.   +12 more
europepmc   +1 more source

Accurate prediction of fetal hemoglobin by Doppler ultrasonography

, 2002
OBJECTIVE: To assess the feasibility of using the middle cerebral artery peak systolic velocity (MCA-PSV) to predict the actual value of fetal hemoglobin in fetuses undergoing a first cordocentesis for detection of anemia caused by maternal red cell ...
Oz, U., Stefos, T., Zimmerman, R., Detti, L., Duerig, P., Mari, G.   +5 more
core  

Human Monocytic Models Reveal Genotype‐Dependent Inflammatory Programs in VEXAS Syndrome

Arthritis &Rheumatology, Accepted Article.
Objectives VEXAS syndrome is a severe X‐linked autoinflammatory disorder caused by somatic mutations in ubiquitin‐like modifier activating enzyme 1 (UBA1), with clinical outcomes that vary by UBA1 genotype. We aimed to elucidate genotype‐specific inflammatory programs and identify potential therapeutic targets.
Kana Higashitani, Tatsuma Ban, Yohei Kirino, Go R Sato, Soichiro Adachi, Yuki Iizuka, Kayo Harita, Ayaka Maeda, Osamu Ohara, Hideaki Nakajima, Tomohiko Tamura   +10 more
wiley   +1 more source

PGC-1α agonism via oral administration of ZLN005 induces fetal hemoglobin and is antisickling in sickle mice. [PDF]

Blood Adv
Benmhammed H, Sun Y, AlAbdullatif S, Chen A, Khan S, Zadeh AM, Mazile N, Beacham GM, Mahdaviani K, Williams C, Alekseyev YO, Campbell JD, Hagedorn EJ, Heaphy C, Klings ES, Steinberg MH, Cui S.   +16 more
europepmc   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

STUDIES ON THE FETAL HEMOGLOBIN OF RABBITS

The Japanese Journal of Physiology, 1964
TYUMA, Itiro, ENOKI, Yasunori, MORIKAWA, Saburo   +2 more
openaire   +3 more sources

Stroke From Paradoxical Embolism in a Young Patient With Sickle-Cell Disease and High Fetal Hemoglobin: A Diagnostic Challenge. [PDF]

Clin Case Rep
Luo YH, Zuberi N, Rizzolo A, Warner M, Isnard S, Routy JP.   +5 more
europepmc   +1 more source

Fetal hemoglobin seviyesinin orak hücre anemisi hastalarının kemik biyokimyası üzerine etkisi

, 2016
Amaç: Bu çalışmanın amacı fetal hemoglobin seviyelerinin, orak hücre anemisi hastalarının kemik parametreleri üzerine olası etkisinin değerlendirilmesidir.Metod: 56'sı SS, 47'si kontrol grubu olmak üzere 103 kan örneği, fetal hemoglobin düzeylerine göre ...
Zeliha Nazan Alparslan, Umut Kökbaş, Abdullah Tuli, Levent Kayrın, Ebru Dündar Yenilmez   +4 more
core