Results 211 to 220 of about 72,054 (299)

Application of Cell‐Free DNA Barcode‐Enabled Single‐Molecule Test for Non‐Invasive Prenatal Testing of α‐Thalassemia and β‐Thalassemia

Journal of Clinical Laboratory Analysis, EarlyView.
We evaluated the cfBEST assay for non‐invasive prenatal testing of α‐ and β‐thalassemia in 72 families. The assay correctly identified 88 of 93 fetal alleles, achieving an overall accuracy of 94.6%, a sensitivity of 94%, and a specificity of 95.35%, with 100% concordance with postnatal follow‐up.
Qin Liu, Na Ma, Wanglan Tang, Qianting Chen, Deguo Tang, Chunyan Zeng, Xiaofeng Wang, Hui Xi   +7 more
wiley   +1 more source

Fetal hemoglobin enables malaria parasite growth in sickle cells but augments production of transmission stage parasites. [PDF]

PLoS One
Lavazec C, Loucoubar C, Dupuy F, Bureau JF, Casadémont I, Gonçalves B, Thein SL, Lathrop M, Laurance S, Roussel C, Le Van Kim C, Colin Y, De Montalembert M, Sakuntabhai A, Paul RE.   +14 more
europepmc   +1 more source

A Comprehensive Study of Bidirectional Interactions Between the Human Microbiome and Blood Malignancies and Hematologic Conditions: Focus on Novel Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Microbiota‐targeted therapeutic strategies in hematological disorders. aHSCT: Transplanted immune cells from the donor may attack the recipient's tissues, especially when damage to the intestinal epithelium disrupts the gut microbiota, contributing to GVHD. Maintaining a balanced gut microbiota that supports immune regulation helps reduce GVHD risk and
Alireza Molajafari, Hadi Sedigh Ebrahim‐Saraie, Majid Taati Moghadam, Meysam Hasannejad‐Bibalan   +3 more
wiley   +1 more source

A new target for fetal hemoglobin reactivation

Haematologica, 2019
Angela Rivers, Robert Molokie, Donald Lavelle   +2 more
doaj   +1 more source

A tetramer of BCL11A is required for stable protein production and fetal hemoglobin silencing. [PDF]

Science
Zheng G, Yin M, Mehta S, Chu IT, Wang S, AlShaye A, Drainville K, Buyanbat A, Bienfait F, Tenglin K, Zhu Q, Orkin SH.   +11 more
europepmc   +1 more source

Correlation of changes in circulating levels of hypoxia-induced factor-1α, erythropoietin, and cell-free fetal hemoglobin with feto-maternal pregnancy outcomes. [PDF]

Braz J Med Biol Res
Mohamed AA, Albahlol IA, Alzarea EA, Alshaikh ABA, Edris FE, Abdel-Tawab MS, El-Metwally TH.   +6 more
europepmc   +1 more source

A preterm neonate with infantile liver failure syndrome 1 due to leucyl‐tRNA synthetase 1 gene (LARS1) mutations with a histopathologic phenotype of neonatal hemochromatosis

JPGN Reports, EarlyView.
Abstract We report a case of a premature, growth‐restricted female infant with feeding intolerance and coagulopathy, treated initially for sepsis, who progressed to neonatal acute liver failure and end‐stage hepatic encephalopathy after a prolonged hospitalization with extensive diagnostic evaluation, and was found by autopsy to have histopathologic ...
Adrienne Bruder, Naomi Laventhal, Raja Rabah, Jacqueline Meadow   +3 more
wiley   +1 more source

Association of early postnatal decline in fetal hemoglobin with bronchopulmonary dysplasia in very low birth weight infants: a cohort study. [PDF]

BMC Pregnancy Childbirth
Niu C, Wu H, Lin Z, Li X, Dang D, Mu X.
europepmc   +1 more source

Controllable DNA Condensation by Mixed Cationic Gemini/Nonionic Surfactant Systems: Structure, Thermodynamics, and Cytotoxicity

Journal of Surfactants and Detergents, EarlyView.
ABSTRACT Controllable DNA condensation is important for nucleic‐acid packaging and non‐viral gene‐delivery systems. This study aimed to determine how the composition of mixed nonionic C12E10 and cationic gemini C12C6C12Br2 surfactants regulates DNA condensation, structure, thermodynamics, and cytotoxicity.
Bo Wang, Linyi Zhu, Yaxun Fan, Yilin Wang   +3 more
wiley   +1 more source

A prime editing strategy to rewrite the γ-globin promoters and reactivate fetal hemoglobin for sickle cell disease.

Blood
Chalumeau A, Bou Dames M, Fontana L, Amistadi S, Antoniou P, Loganathan P, Mombled M, Corre G, Peterka M, Amendola M, Giovannangeli C, Maresca M, Miccio A, Brusson M.   +13 more
europepmc   +1 more source