Results 71 to 80 of about 850,904 (382)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Poorly controlled diabetes mellitus alters placental structure, efficiency, and plasticity

BMJ Open Diabetes Research & Care, 2020
Introduction The hemochorial placenta provides a critical barrier at the maternal–fetal interface to modulate maternal immune tolerance and enable gas and nutrient exchange between mother and conceptus.
Jackson Nteeba, Kaela M Varberg, Regan L Scott, Mikaela E Simon, Khursheed Iqbal, Michael J Soares   +5 more
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Diagnostic and prognostic value of analysis of heart rhythm variability in pregnant patients under estimation of fetal hypoxia evidence [PDF]

Саратовский научно-медицинский журнал, 2010
The correlation between fetal hypoxia degrees according to the data of cardiotocography and status of mother's vegetative nervous system as a result of heart rhythm variability research have been analyzed.
Piskunova L.V., Chekhonatskaya M.L., Arenina N.Yu.   +2 more
doaj  

High‐fat diet intake modulates maternal intestinal adaptations to pregnancy and results in placental hypoxia, as well as altered fetal gut barrier proteins and immune markers

Journal of Physiology, 2019
Maternal obesity has been associated with shifts in intestinal microbiota, which may contribute to impaired barrier function Impaired barrier function may expose the placenta and fetus to pro‐inflammatory mediators We investigated the impacts of diet ...
W. Gohir, K. M. Kennedy, Jessica G Wallace, Michelle Saoi, Christian J. Bellissimo, P. Britz‐McKibbin, J. Petrik, M. Surette, D. Sloboda   +8 more
semanticscholar   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant. [PDF]

, 2017
The advent of large-scale in vitro differentiation of human stem cell-derived insulin-producing cells (SCIPC) has brought us closer to treating diabetes using stem cell technology. However, decades of experiences from islet transplantation show that
Faleo, Gaetano, Freise, Jonathan E, Hebrok, Matthias, Nair, Gopika G, Nguyen, Vinh, Parent, Audrey V, Russ, Holger A, Szot, Gregory L, Tang, Qizhi, Villanueva, Karina E, Wisel, Steven   +10 more
core   +2 more sources

A study of placental histological changes in gestational diabetes mellitus on account of fetal hypoxia

, 2016
Background: Diabetes in pregnancy has been associated with increased fetal growth and with a high risk of prenatal and postnatal complications. Metabolic impairments in maternal obesity and gestational diabetes mellitus (GMD) provoke an unusual commotion
G. Augustine, Mumtaz Pulikkathodi, S. Renjith, Jithesh Tk   +3 more
semanticscholar   +1 more source

Placental mitochondria adapt developmentally and in response to hypoxia to support fetal growth

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Mitochondria are the primary source of ATP for placental growth, transport, and hormone synthesis. However, to date, little is known about the developmental regulation or functional significance of placental mitochondria during normal or ...
A. Sferruzzi-Perri, J. Higgins, O. Vaughan, A. Murray, A. Fowden   +4 more
semanticscholar   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source