Results 1 to 10 of about 132,868 (270)

How does fetal inflammatory response syndrome change fetal response to hypoxia? An experimental study in a fetal sheep model. [PDF]

Acta Obstet Gynecol Scand
International audienceIntroductionFetal inflammatory response syndrome associated with acidosis during labor is a high-risk situation for the fetus.
Chevalier G, Garabedian C, De Stephano V, Wojtanowski A, Ould Hamoud Y, Galan L, Sharma D, Le Duc K, De Jonckheere J, Storme L, Marot G, Ghesquière L.   +11 more
europepmc   +7 more sources

Infection Induced Fetal Inflammatory Response Syndrome (FIRS): State-of- the-Art and Medico-Legal Implications-A Narrative Review. [PDF]

Microorganisms, 2023
Fetal inflammatory response syndrome (FIRS) represents the fetal inflammatory reaction to intrauterine infection or injury, potentially leading to multiorgan impairment, neonatal mortality, and morbidity. Infections induce FIRS after chorioamnionitis (CA)
Giovannini E, Bonasoni MP, Pascali JP, Giorgetti A, Pelletti G, Gargano G, Pelotti S, Fais P.   +7 more
europepmc   +6 more sources

Contribution of Fetal Inflammatory Response Syndrome (FIRS) with or without Maternal-Fetal Inflammation in The Placenta to Increased Risk of Respiratory and Other Complications in Preterm Neonates. [PDF]

Biomedicines, 2023
This study classifies fetal inflammatory response syndrome (FIRS) based on the presence or absence of maternal-fetal inflammation in the placenta and clarifies the association of FIRS with neonatal morbidities.
Nomiyama M, Nakagawa T, Yamasaki F, Hisamoto N, Yamashita N, Harai A, Gondo K, Ikeda M, Tsuda S, Ishimatsu M, Oshima Y, Ono T, Kozuma Y, Tsumura K.   +13 more
europepmc   +5 more sources

Early heart rate variability changes during acute fetal inflammatory response syndrome: An experimental study in a fetal sheep model. [PDF]

PLoS One, 2023
IntroductionFetal infection during labor with fetal inflammatory response syndrome (FIRS) is associated with neurodevelopmental disabilities, cerebral palsy, neonatal sepsis, and mortality. Current methods to diagnose FIRS are inadequate. Thus, the study
Chevalier G, Garabedian C, Pekar JD, Wojtanowski A, Le Hesran D, Galan LE, Sharma D, Storme L, Houfflin-Debarge V, De Jonckheere J, Ghesquière L.   +10 more
europepmc   +3 more sources

Evidence of cardiac involvement in the fetal inflammatory response syndrome: disruption of gene networks programming cardiac development in nonhuman primates. [PDF]

Am J Obstet Gynecol, 2018
BACKGROUND: Most early preterm births are associated with intraamniotic infection and inflammation, which can lead to systemic inflammation in the fetus.
Mitchell T, MacDonald JW, Srinouanpranchanh S, Bammler TK, Merillat S, Boldenow E, Coleman M, Agnew K, Baldessari A, Stencel-Baerenwald JE, Tisoncik-Go J, Green RR, Gale MJ, Rajagopal L, Adams Waldorf KM.   +14 more
europepmc   +3 more sources

The fetal inflammatory response syndrome

American Journal of Obstetrics and Gynecology, 1998
OBJECTIVE: The objective of this study was to determine the frequency and clinical significance of a systemic inflammatory response as defined by an elevated plasma interleukin-6 concentration in fetuses with preterm labor or preterm premature rupture of
Ricardo Gomez, Roberto Romero, Fabio Ghezzi   +2 more
exaly   +4 more sources

Leukocytosis as a prognostic marker in the development of fetal inflammatory response syndrome. [PDF]

Libyan J Med, 2013
To identify and evaluate the correlation between leukocyte count in maternal blood and the risk of developing fetal inflammatory response syndrome (FIRS).The study involved 158 infants born at 22 - 34 weeks of gestation and their mothers. Umbilical cord blood cytokines were evaluated in immunoassay tests and maternal blood was tested for the leukocyte ...
Bartkeviciene D, Pilypiene I, Drasutiene G, Bausyte R, Mauricas M, Silkunas M, Dumalakiene I.   +6 more
europepmc   +5 more sources

The transcriptome of the fetal inflammatory response syndrome. [PDF]

Am J Reprod Immunol, 2010
The fetal inflammatory response syndrome (FIRS) is considered the counterpart of the systemic inflammatory response syndrome (SIRS), but similarities in their regulatory mechanisms are unclear. This study characterizes the fetal mRNA transcriptome of peripheral leukocytes to identify key biological processes and pathways involved in FIRS.Umbilical cord
Madsen-Bouterse SA, Romero R, Tarca AL, Kusanovic JP, Espinoza J, Kim CJ, Kim JS, Edwin SS, Gomez R, Draghici S.   +9 more
europepmc   +6 more sources

Fetal thymic involution: a sonographic marker of the fetal inflammatory response syndrome

American Journal of Obstetrics and Gynecology, 2005
OBJECTIVE: The purpose of this study was to evaluate whether there is a relationship between the sonographic fetal thymus size and the presence of an intrauterine infection in patients with preterm labor.
D'Addario, Vincenzo, RAIO L, Cromi, A., Uccella, Stefano, Ghezzi, F., Raio, Luigi, Loverro, G., Di Naro, Edoardo, DI NARO E, CROMI A, Raio, L., D(')Addario, V., D'ADDARIO V, Di Naro, E., Loverro, Giuseppe, GHEZZI F, Uccella, S., Ghezzi, Fabio, UCCELLA S, Cromi, Antonella, LOVERRO G.   +20 more
core   +7 more sources

The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis, and obstetrical implications. [PDF]

Semin Fetal Neonatal Med, 2020
The fetus can deploy a local or systemic inflammatory response when exposed to microorganisms or, alternatively, to non-infection-related stimuli (e.g., danger signals or alarmins). The term "Fetal Inflammatory Response Syndrome" (FIRS) was coined to describe a condition characterized by evidence of a systemic inflammatory response, frequently a result
Jung E, Romero R, Yeo L, Diaz-Primera R, Marin-Concha J, Para R, Lopez AM, Pacora P, Gomez-Lopez N, Yoon BH, Kim CJ, Berry SM, Hsu CD.   +12 more
europepmc   +4 more sources