Results 91 to 100 of about 132,868 (270)

Peroxisome Proliferator-Activated Receptor alpha (PPAR alpha) down-regulation in cystic fibrosis lymphocytes

, 2006
Background: PPARs exhibit anti-inflammatory capacities and are potential modulators of the inflammatory response. We hypothesized that their expression and/or function may be altered in cystic fibrosis (CF), a disorder characterized by an excessive host ...
Wagner, Thomas, Reynders, Veerle, Veerle Reynders, Stefan Loitsch, Joachim Bargon, Reynders Veerle, Thomas Wagner, Steinhauer, Constanze, Bargon Joachim, Steinhilber Dieter, Bargon, Joachim, Loitsch Stefan, Dieter Steinhilber, Constanze Steinhauer, Loitsch, Stefan Marcel, Wagner Thomas, Steinhauer Constanze, Steinhilber, Dieter   +17 more
core   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Effect of a maternal inflammatory challenge during the preimplantation period on offspring development and phenotype

, 2009
The preimplantation mammalian embryo is sensitive to its immediate surroundings: alterations to its in vitro or in vivo environment can affect not only the immediate events of blastocyst formation, but can also give rise to long-term phenotypic ...
Williams, Charlotte Lucy
core  

Inflammation-Induced Adverse Pregnancy and Neonatal Outcomes Can Be Improved by the Immunomodulatory Peptide Exendin-4

Frontiers in Immunology, 2018
Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. Inflammation is causally linked to preterm birth; therefore, finding an intervention that dampens maternal and fetal inflammatory responses may provide a new strategy to ...
Valeria Garcia-Flores, Valeria Garcia-Flores, Valeria Garcia-Flores, Valeria Garcia-Flores, Roberto Romero, Roberto Romero, Roberto Romero, Roberto Romero, Roberto Romero, Derek Miller, Derek Miller, Derek Miller, Derek Miller, Yi Xu, Yi Xu, Yi Xu, Bogdan Done, Bogdan Done, Bogdan Done, Chharitha Veerapaneni, Yaozhu Leng, Yaozhu Leng, Yaozhu Leng, Marcia Arenas-Hernandez, Marcia Arenas-Hernandez, Marcia Arenas-Hernandez, Marcia Arenas-Hernandez, Nabila Khan, Bogdan Panaitescu, Bogdan Panaitescu, Bogdan Panaitescu, Sonia S. Hassan, Sonia S. Hassan, Sonia S. Hassan, Luis Marat Alvarez-Salas, Nardhy Gomez-Lopez, Nardhy Gomez-Lopez, Nardhy Gomez-Lopez, Nardhy Gomez-Lopez   +38 more
doaj   +1 more source

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Pro- and anti-inflammatory cytokines in threatened miscarriages [PDF]

, 2011
OBJECTIVE: The purpose of this study was to evaluate circulating and intracellular levels of Th1 and Th2 cytokines in women with threatenedmiscarriage (TM) and subsequent outcome.
Jean Calleja-Agius, Arnold R. Pizzey, Calleja-Agius, Jean, Jauniaux, Eric R.M., Shanthi Muttukrishna, Eric Jauniaux, Muttukrishna, Shanthi, Pizzey, Arnold R.   +7 more
core   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Genome-wide analysis of the transcriptional response to porcine reproductive and respiratory syndrome virus infection at the maternal/fetal interface and in the fetus

, 2016
Background Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant pigs can result in congenital infection and ultimately fetal death.
Harding, John C. S., Ladinig, Andrea, Wilkinson, Jamie M., Stothard, Paul, Hong, Linjun, Lunney, Joan K., Bao, Hua, Plastow, Graham S.   +7 more
core   +1 more source