Results 111 to 120 of about 133,571 (269)

Placental Histopathology and Clinical Presentation of Severe Congenital Zika Syndrome in a Human Immunodeficiency Virus-Exposed Uninfected Infant

Frontiers in Immunology, 2017
In the large Zika virus (ZIKV) epidemic that occurred in Brazil in 2015, the intrauterine fetal exposure to ZIKV was associated with a significant risk of developing microcephaly and neurological disorders in the infected infants. ZIKV-associated disease
Kíssila Rabelo, Regina Célia de Souza Campos Fernandes, Regina Célia de Souza Campos Fernandes, Luiz José de Souza, Thais Louvain de Souza, Thais Louvain de Souza, Flávia Barreto dos Santos, Priscila Conrado Guerra Nunes, Elzinandes Leal de Azeredo, Natália Gedeão Salomão, Gisela Freitas Trindade, Carlos A. Basílio-de-Oliveira, Jorge José de Carvalho, Enrique Medina-Acosta, Marciano Viana Paes   +14 more
doaj   +1 more source

The 9th International RASopathies Symposium

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel, Lisa Schoyer, Beth Stronach, Raya Bogdanova, Anton M. Bennett, Jaishri Blakeley, Miriam Bornhorst, Tammy Bowers, Saskia M. Brachmann, Emma Burkitt‐Wright, Kathryn Chatfield, Alessandro De Luca, Khalil El‐Chammas, Abdul Elkadri, John E. Fortunato, Bruce D. Gelb, Anne Goriely, Karen Gripp, Kassidy Grover, Lindsay Homan, Kenneth A. Kern, Maija Kiuru, Charles (Chuck) Lawson, Yong‐Seok Lee, Frank McCormick, Gina Ney, Cristina Nuevo‐Tapioles, Sara Pardej, Elizabeth I. Pierpont, Julia Plank, Nancy Ratner, Katherine A. Rauen, J. Elliott Robinson, Les Rogers, Sarah E. Sheppard, Keir Shiels, David Stevenson, Dagmar Tiemens, Matthew Traylor, K. Nicole Weaver, Marielle Yohe, Tamar Green   +41 more
wiley   +1 more source

CORIOAMNIONITIS HISTOLÓGICA Y MORBIMORTALIDAD NEONATAL: APROXIMACIÓN AL SÍNDROME DE RESPUESTA INFLAMATORIA FETAL

Revista Chilena de Obstetricia y Ginecología, 2010
Antecedentes: El síndrome de respuesta inflamatoria fetal (SRIF) es una entidad relacionada con la presencia de inflamación intrauterina y suele asociarse a infección intraamniótica.
M. Inmaculada Rincón Ricote, Fernando Magdaleno Dans, Marta Sancha Naranjo, Félix Omeñaca Teres, Antonio González González   +4 more
doaj  

Targeted Anti‐IL‐1 Immunomodulatory Therapy in Pediatric Onset PPP1R13L‐Related Arrhythmogenic Cardiomyopathy

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg, Savannah Coppersmith, Owen Merritt, Amer Heider, Adam Helms, Thomas Michniacki, Jack Luxford, Sarah Josephi‐Taylor, Philip Roberts, Joshua Meisner   +9 more
wiley   +1 more source

The significance of TNF-α and MMP-8 concentrations in non-invasively obtained amniotic fluid predicting fetal inflammatory response syndrome. [PDF]

Int J Gynaecol Obstet, 2023
Gulbiniene V, Balciuniene G, Dumalakiene I, Viliene R, Pilypiene I, Ramasauskaite D.   +5 more
europepmc   +1 more source

Chorioamnionitis induced hepatic inflammation and disturbed lipid metabolism in fetal sheep. [PDF]

, 2010
Chorioamnionitis frequently induces a fetal inflammatory response syndrome (FIRS), characterized by an elevation of pro-inflammatory mediators and systemic inflammation.
Zimmermann, L.J.I., Veerle Bieghs, Shiri-Sverdlov, R.; id_orcid, Shiri-Sverdlov, R., Dieter Lütjohann, Gijbels, Marion J., Boris W Kramer, Kramer, B.W., Vlassaks, Evi, van Gorp, Patrick J., Voncken, J.W., Bekers, Otto, Lutjohann, D., Bekers, O., van Gorp, P.J.J.; id_orcid, Custers, Anne, Luc J I Zimmermann, Ronit Shiri-Sverdlov, Gavilanes, A.W., Voncken, J.-Willem, J -Willem Voncken, Vlassaks, E., Patrick J Van Gorp, Bieghs, Veerle, Evi Vlassaks, Custers, A., Lütjohann, Dieter, Anne Custers, Marion J Gijbels, Bast, Aalt, Zimmermann, Luc J. I., van Gorp, P.J.J., Kramer, Boris W., Otto Bekers, Bieghs, V., Gavilanes, A. W. Danilo, Gijbels, M.J.J., A W Danilo Gavilanes, Bast, A., Shiri-Sverdlov, Ronit, Aalt Bast   +40 more
core   +1 more source

Histidine Supplementation Stabilizes Hearing and Vision and Improves Growth in HARS1‐Related Autosomal Recessive Disorder Associated With Usher‐Like Symptoms

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive HARS1‐related disorder (originally described as Usher syndrome type 3B) caused by a homozygous Y454S variant in the histidyl‐tRNA synthetase gene (HARS1) is characterized by progressive sensorineural hearing and vision loss and respiratory deterioration with risk for sudden death following febrile illnesses.
Victoria Mok Siu, Rosan Kenana, Rana Chakrabarti, Sarah D. P. Wilhelm, Joseph Andrews, Susan J. Leat, Christina Parker, Michael Miller, Leslie A. Nangle, Wendy McCaul, Ashfia Chowdhury, Natalie Hutchings, Ryan A. Adams, Lauren Guy, Mandy Rhody, Verena Juncal, Marisa I. Mendes, Desiree E. C. Smith, Gajja S. Salomons, Angelica A. Moresco, Daphne L. McCulloch, D. Holmes Morton, Ilka U. Heinemann, C. Anthony Rupar   +23 more
wiley   +1 more source

The maternal and fetal inflammatory response in normal pregnancy and fetal growth restriction: An ultrasound, flow-cytometry and immunoassay study

, 2015
The fetal vascular phenotype in fetal growth restriction (FGR) is significantly altered, with affected fetuses appearing to have relatively more dilated vessels with increased proportional blood flow to the head and neck arteries.
Mullins, Edward William Samuel
core   +1 more source

A preclinical mouse model mimicking the ovarian cancer‐induced estrogen deficiency‐depression axis

Animal Models and Experimental Medicine, EarlyView.
A preclinical mouse model of ovarian cancer–related depression was developed by combining intraperitoneal tumor cell injection, ovariectomy, and chronic restraint stress. The model replicates key clinical features including estrogen deficiency, depressive‐like behaviors, and tumor progression, and provides a reliable tool for studying the endocrine ...
Jiamin Liu, Yafei Yang, Chunxi Liu, Danting Wen, Tingyu Zhao, Ping Xie, Jing Xiao   +6 more
wiley   +1 more source

The Distinct Immune Nature of the Fetal Inflammatory Response Syndrome Type I and Type II. [PDF]

Immunohorizons, 2021
Para R, Romero R, Miller D, Galaz J, Done B, Peyvandipour A, Gershater M, Tao L, Motomura K, Ruden DM, Isherwood J, Jung E, Kanninen T, Pique-Regi R, Tarca AL, Gomez-Lopez N.   +15 more
europepmc   +1 more source