Results 101 to 110 of about 132,868 (270)

Antenatal diagnosis of chorioamnionitis: A review of the potential role of fetal and placental imaging

, 2022
Chorioamnionitis is present in up to 70% of spontaneous preterm births. It is defined as an acute inflammation of the chorion, with or without involvement of the amnion, and is evidence of a maternal immunological response to infection.
Tribe, Rachel M., Suff, Natalie, Carla Avena Zampieri, Rachel M. Tribe, Andrew Shennan, Tribe, Rachel M.; id_orcid, Jana Hutter, Lisa Story, Hutter, Jana, Hutter, Jana; id_orcid, Rutherford, Mary, Hall, Megan, Natalie Suff, Mary Rutherford, Shennan, Andrew, Story, Lisa, Megan Hall, Story, Lisa; id_orcid, Avena Zampieri, Carla   +18 more
core   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Placental Histopathology and Clinical Presentation of Severe Congenital Zika Syndrome in a Human Immunodeficiency Virus-Exposed Uninfected Infant

Frontiers in Immunology, 2017
In the large Zika virus (ZIKV) epidemic that occurred in Brazil in 2015, the intrauterine fetal exposure to ZIKV was associated with a significant risk of developing microcephaly and neurological disorders in the infected infants. ZIKV-associated disease
Kíssila Rabelo, Regina Célia de Souza Campos Fernandes, Regina Célia de Souza Campos Fernandes, Luiz José de Souza, Thais Louvain de Souza, Thais Louvain de Souza, Flávia Barreto dos Santos, Priscila Conrado Guerra Nunes, Elzinandes Leal de Azeredo, Natália Gedeão Salomão, Gisela Freitas Trindade, Carlos A. Basílio-de-Oliveira, Jorge José de Carvalho, Enrique Medina-Acosta, Marciano Viana Paes   +14 more
doaj   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

CORIOAMNIONITIS HISTOLÓGICA Y MORBIMORTALIDAD NEONATAL: APROXIMACIÓN AL SÍNDROME DE RESPUESTA INFLAMATORIA FETAL

Revista Chilena de Obstetricia y Ginecología, 2010
Antecedentes: El síndrome de respuesta inflamatoria fetal (SRIF) es una entidad relacionada con la presencia de inflamación intrauterina y suele asociarse a infección intraamniótica.
M. Inmaculada Rincón Ricote, Fernando Magdaleno Dans, Marta Sancha Naranjo, Félix Omeñaca Teres, Antonio González González   +4 more
doaj  

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

The significance of TNF-α and MMP-8 concentrations in non-invasively obtained amniotic fluid predicting fetal inflammatory response syndrome. [PDF]

Int J Gynaecol Obstet, 2023
Gulbiniene V, Balciuniene G, Dumalakiene I, Viliene R, Pilypiene I, Ramasauskaite D.   +5 more
europepmc   +1 more source

Chorioamnionitis induced hepatic inflammation and disturbed lipid metabolism in fetal sheep. [PDF]

, 2010
Chorioamnionitis frequently induces a fetal inflammatory response syndrome (FIRS), characterized by an elevation of pro-inflammatory mediators and systemic inflammation.
Zimmermann, L.J.I., Veerle Bieghs, Shiri-Sverdlov, R.; id_orcid, Shiri-Sverdlov, R., Dieter Lütjohann, Gijbels, Marion J., Boris W Kramer, Kramer, B.W., Vlassaks, Evi, van Gorp, Patrick J., Voncken, J.W., Bekers, Otto, Lutjohann, D., Bekers, O., van Gorp, P.J.J.; id_orcid, Custers, Anne, Luc J I Zimmermann, Ronit Shiri-Sverdlov, Gavilanes, A.W., Voncken, J.-Willem, J -Willem Voncken, Vlassaks, E., Patrick J Van Gorp, Bieghs, Veerle, Evi Vlassaks, Custers, A., Lütjohann, Dieter, Anne Custers, Marion J Gijbels, Bast, Aalt, Zimmermann, Luc J. I., van Gorp, P.J.J., Kramer, Boris W., Otto Bekers, Bieghs, V., Gavilanes, A. W. Danilo, Gijbels, M.J.J., A W Danilo Gavilanes, Bast, A., Shiri-Sverdlov, Ronit, Aalt Bast   +40 more
core   +1 more source

The 9th International RASopathies Symposium

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel, Lisa Schoyer, Beth Stronach, Raya Bogdanova, Anton M. Bennett, Jaishri Blakeley, Miriam Bornhorst, Tammy Bowers, Saskia M. Brachmann, Emma Burkitt‐Wright, Kathryn Chatfield, Alessandro De Luca, Khalil El‐Chammas, Abdul Elkadri, John E. Fortunato, Bruce D. Gelb, Anne Goriely, Karen Gripp, Kassidy Grover, Lindsay Homan, Kenneth A. Kern, Maija Kiuru, Charles (Chuck) Lawson, Yong‐Seok Lee, Frank McCormick, Gina Ney, Cristina Nuevo‐Tapioles, Sara Pardej, Elizabeth I. Pierpont, Julia Plank, Nancy Ratner, Katherine A. Rauen, J. Elliott Robinson, Les Rogers, Sarah E. Sheppard, Keir Shiels, David Stevenson, Dagmar Tiemens, Matthew Traylor, K. Nicole Weaver, Marielle Yohe, Tamar Green   +41 more
wiley   +1 more source