Results 21 to 30 of about 7,077,080 (366)

Fetal articular cartilage regeneration versus adult fibrocartilaginous repair: secretome proteomics unravels molecular mechanisms in an ovine model

Disease Models & Mechanisms, 2018
Osteoarthritis (OA), a degenerative joint disease characterized by progressive cartilage degeneration, is one of the leading causes of disability worldwide owing to the limited regenerative capacity of adult articular cartilage.
Iris Ribitsch, Rupert L. Mayer, Monika Egerbacher, Simone Gabner, Maciej M. Kańduła, Julie Rosser, Eva Haltmayer, Ulrike Auer, Sinan Gültekin, Johann Huber, Andrea Bileck, David P. Kreil, Christopher Gerner, Florien Jenner   +13 more
doaj   +1 more source

Maternal PlGF and umbilical Dopplers predict pregnancy outcomes at diagnosis of early-onset fetal growth restriction

The Journal of Clinical Investigation, 2023
BACKGROUND Severe, early-onset fetal growth restriction (FGR) causes significant fetal and neonatal mortality and morbidity. Predicting the outcome of affected pregnancies at the time of diagnosis is difficult, thus preventing accurate patient counseling.
Rebecca Spencer, Kasia Maksym, Kurt Hecher, Karel Maršál, Francesc Figueras, Gareth Ambler, Harry Whitwell, Nuno Rocha Nené, Neil J. Sebire, Stefan R. Hansson, Anke Diemert, Jana Brodszki, Eduard Gratacós, Yuval Ginsberg, Tal Weissbach, Donald M. Peebles, Ian Zachary, Neil Marlow, Angela Huertas-Ceballos, Anna L. David   +19 more
doaj   +1 more source

Maternal zinc intakes and homeostatic adjustments during pregnancy and lactation. [PDF]

, 2012
Zinc plays critical roles during embryogenesis, fetal growth, and milk secretion, which increase the zinc need for pregnancy and lactation. Increased needs can be met by increasing the dietary zinc intake, along with making homeostatic adjustments in ...
Donangelo, Carmen, King, Janet
core   +2 more sources

Proteomic analysis of adipose tissue during the last weeks of gestation in pure and crossbred Large White or Meishan fetuses gestated by sows of either breed

Journal of Animal Science and Biotechnology, 2018
Background The degree of adipose tissue development at birth may influence neonatal survival and subsequent health outcomes. Despite their lower birth weights, piglets from Meishan sows (a fat breed with excellent maternal ability) have a higher survival
F. Gondret, B. Guével, M. C. Père, H. Quesnel, Y. Billon, E. Com, L. Canario, I. Louveau, L. Liaubet   +8 more
doaj   +1 more source

Profiling extra cellular matrix associated proteome of human fetal nucleus pulposus in search for regenerative targets

Scientific Reports, 2021
Degeneration of the intervertebral disc is associated with a decrease in extra-cellular matrix (ECM) content due to an imbalance in anabolic and catabolic signaling.
Shanmuganathan Rajasekaran, Chitra Thangavel, Niek Djuric, Muthurajan Raveendran, Dilip Chand Raja Soundararajan, Sharon Miracle Nayagam, Monica Steffi Matchado, K. S. Sri Vijay Anand, Krishna Venkateshwaran   +8 more
doaj   +1 more source

Perinatal Gene Transfer to the Liver [PDF]

, 2011
The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect. Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within
Buckley, SM, Chan, JK, Howe, SJ, McKay, TR, Rahim, AA, Waddington, SN, Ward, NJ   +6 more
core   +1 more source

IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise

Science, 2019
Placenta formation and fetal demise A critical step of placental development is the fusion of trophoblast cells into a multi-nucleated syncytiotrophoblast layer.
Julian Buchrieser, S. Degrelle, T. Couderc, Quentin Nevers, Olivier Disson, Caroline Manet, D. Donahue, F. Porrot, K. Hillion, Émeline Perthame, Marlene V Arroyo, S. Souquere, K. Ruigrok, A. Dupressoir, T. Heidmann, X. Montagutelli, T. Fournier, Marc Lecuit, O. Schwartz   +18 more
semanticscholar   +1 more source

Placental proteome abnormalities in women with gestational diabetes and large-for-gestational-age newborns

BMJ Open Diabetes Research & Care, 2020
Introduction Gestational diabetes mellitus (GDM) is the most frequent metabolic complication during pregnancy and is associated with development of short-term and long-term complications for newborns, with large-for-gestational-age (LGA) being ...
Irene Cetin, Emma Assi, Francesca D'Addio, Chiara Mandò, Anna Maestroni, Cristian Loretelli, Moufida Ben Nasr, Vera Usuelli, Ahmed Abdelsalam, Andy Joe Seelam, Ida Pastore, Cinzia Magagnotti, Reza Abdi, Basset El Essawy, Franco Folli, Domenico Corradi, Gianvincenzo Zuccotti, Paolo Fiorina   +17 more
doaj   +1 more source

Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum. [PDF]

, 2018
BACKGROUND: The study of Onchocerca volvulus has been limited by its host range, with only humans and non-human primates shown to be susceptible to the full life cycle infection.
Abraham, David, Bennuru, Sasisekhar, Eberhard, Mark L., Hess Ligas, Jessica A., Lustigman, Sara, Nutman, Thomas B., Patton, John B., Torigian, April R.   +7 more
core   +3 more sources

Epigenomic and Proteomic Changes in Fetal Spleens Persistently Infected with Bovine Viral Diarrhea Virus: Repercussions for the Developing Immune System, Bone, Brain, and Heart

Viruses, 2022
Bovine viral diarrhea virus (BVDV) infection during early gestation results in persistently infected (PI) immunotolerant calves that are the primary reservoirs of the virus. Pathologies observed in PI cattle include congenital defects of the brain, heart,
Hanah M. Georges, Hana Van Campen, Helle Bielefeldt-Ohmann, Thomas R. Hansen   +3 more
doaj   +1 more source