Results 71 to 80 of about 1,024,043 (307)

Large-scale discovery of enhancers from human heart tissue. [PDF]

, 2011
Development and function of the human heart depend on the dynamic control of tissue-specific gene expression by distant-acting transcriptional enhancers.
Afzal, Veena, Akiyama, Jennifer A, Black, Brian L, Blow, Matthew J, Bristow, James, Holt, Amy, Jensen, Brian C, Kaplan, Tommy, May, Dalit, McCulley, David J, Pennacchio, Len A, Plajzer-Frick, Ingrid, Rubin, Edward M, Shoukry, Malak, Simpson, Paul C, Visel, Axel, Wright, Crystal   +16 more
core  

Serum Hsp70 antigen: Early diagnosis marker in perinatal asphyxia [PDF]

, 2015
BACKGROUND: Perinatal asphyxia is an important cause of mortality and permanent neurological and developmental deficit. Early and accurate diagnosis would help to establish the likely prognosis and may also help in determining the most appropriate ...
Boskabadi, Hassan, Ferns, Gordon A A, Mobarhan, Majid Ghayour, Mohammadi, Shabnam, Omidian, Masoud, Parizadeh, Mostafa, Tavallai, Shima   +6 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Deregulated protein homeostasis constrains fetal hematopoietic stem cell pool expansion in Fanconi anemia

Nature Communications
Demand-adjusted and cell type specific rates of protein synthesis represent an important safeguard for fate and function of long-term hematopoietic stem cells.
Narasaiah Kovuru, Makiko Mochizuki-Kashio, Theresa Menna, Greer Jeffrey, Yuning Hong, Young me Yoon, Zhe Zhang, Peter Kurre   +7 more
doaj   +1 more source

The characterization of preterm newborn saliva by top-down proteomic as a stimulus for the study of human development. A review of the results obtained over the past 25 years

Journal of Pediatric and Neonatal Individualized Medicine
Around the first years of 2000, our teams, at the Cagliari and Catholic-Policlinico Gemelli (Rome) Universities, started an investigation of the in­tact proteins of human saliva by a top-down pipeline.
Tiziana Cabras, Barbara Manconi, Alessandra Olianas, Maria Teresa Sanna, Cristina Contini, Giulia Guadalupi, Antonella Fiorita, Lea Calò, Gaetano Paludetti, Emanuele Scarano, Chiara Tirone, Giovanni Vento, Simona Fattore, Nicoletta Menzella, Davide De Tomaso, Federica Iavarone, Irene Messana, Claudia Desiderio, Diana Valeria Rossetti, Matteo Fraschini, Vassilios Fanos, Jacopo Galli, Gavino Faa, Massimo Castagnola   +23 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Transplacental SARS-CoV-2 protein ORF8 binds to complement C1q to trigger fetal inflammation

The EMBO Journal
Prenatal SARS-CoV-2 infection is associated with higher rates of pregnancy and birth complications, despite that vertical transmission rates are thought to be low.
Tamiris Azamor, Débora Familiar-Macedo, Gielenny M Salem, Chineme Onwubueke, Ivonne Melano, Lu Bian, Zilton Vasconcelos, Karin Nielsen-Saines, Xianfang Wu, Jae U Jung, Feng Lin, Oluwatosin Goje, Edward Chien, Steve Gordon, Charles B Foster, Hany Aly, Ruth M Farrell, Weiqiang Chen, Suan-Sin Foo   +18 more
doaj   +1 more source

BPI-fold (BPIF) containing/plunc protein expression in human fetal major and minor salivary glands

Brazilian Oral Research
The aim of this study was to determine expression, not previously described, of PLUNC (palate, lung, and nasal epithelium clone) (BPI-fold containing) proteins in major and minor salivary glands from very early fetal tissue to the end of the second ...
Daniel Berretta Moreira ALVES, Lynne BINGLE, Colin David BINGLE, Silvia Vanessa LOURENÇO, Andréia Aparecida SILVA, Débora Lima PEREIRA, Pablo Agustin VARGAS   +6 more
doaj   +1 more source

Comparative Proteomic Profile of the Human Placenta in Normal and Fetal Growth Restriction Subjects

Cellular Physiology and Biochemistry, 2014
Background: Fetal growth restriction (FGR) is the main cause of intrauterine fetal death and the second leading cause of death in the neonatal period. A large body of evidence suggests that FGR may be associated with the placenta, although its etiology ...
Zhijing Miao, Min Chen, Hong Wu, Hongjuan Ding, Zhonghua Shi   +4 more
doaj   +1 more source

Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas. [PDF]

, 2019
Congenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects worldwide, yet the most effective strategies for preventing virus transmission during pregnancy are unknown.
An, Zhiqiang, Fang-Hoover, June, Freed, Daniel C, Fu, Tong-Ming, Li, Fengsheng, Pereira, Lenore, Petitt, Matthew, Tabata, Takako, Wang, Dai   +8 more
core   +1 more source