Results 51 to 60 of about 319,473 (298)

Few-Mode Fibers: Characterizations and Applications

2023 Optical Fiber Communications Conference and Exhibition (OFC), 2023
We report design guidelines and modal loss characterizations (light scattering and extra-loss phenomena) of few-mode fibers that allow optimizing their crosstalk, differential mode group delay and differential mode attenuation for practical applications.
Bigot, M., Bsaibes, M., Bigot, Laurent, Quiquempois, Y., Sillard, P.   +4 more
openaire   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Graphene mode locked, wavelength-tunable, dissipative soliton fiber laser

, 2010
Atomic layer graphene possesses wavelength-insensitive ultrafast saturable absorption, which can be exploited as a full-band mode locker. Taking advantage of the wide band saturable absorption of the graphene, we demonstrate experimentally that wide ...
Bao, Qiaoliang, Knize, R. J., Loh, Kian Ping, Tang, Dingyuan, Zhang, Han, Zhao, Luming   +5 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Block-Based Mode Decomposition in Few-Mode Fibers

Photonics
A block-based mode decomposition (BMD) algorithm is proposed in this paper, which reduces computational complexity and enhances noise resistance. The BMD uses randomly selected sample blocks of the beam images to restore mode coefficients instead of all ...
Chenyu Wang, Jianyong Zhang, Baorui Yan, Shuchao Mi, Guofang Fan, Muguang Wang, Peiying Zhang   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

High-order-mode Brillouin random fiber laser based on distributed Rayleigh scattering in all-few mode fiber half-open cavity

Results in Physics
A high-order-mode (HOM) Brillouin random fiber laser (BRFL) based on distributed Rayleigh scattering in an all-few-mode fiber random cavity is proposed and experimentally demonstrated.
Zizhou Wei, Liang Zhang, Yichun Li, Wei Chen, Han Wang, Mengshi Zhu, Xianglong Zeng, Fufei Pang, Tingyun Wang   +8 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Superposing Multiple LP Modes With Microphase Difference Distributed Along Fiber to Generate OAM Mode

IEEE Photonics Journal, 2017
We propose a new method to generate orbital angular momentum (OAM) mode by superposing multiple LP11 modes with microphase difference distributed along fiber propagation. This way, OAM mode can be generated by superposing a series of LP11 mode with phase
Yangjin Li, Long Jin, Hang Wu, Shecheng Gao, Yuan-Hua Feng, Zhaohui Li   +5 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source