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Overview of the FGF23-Klotho axis
Pediatric Nephrology, 2009Recent studies have identified a novel bone-kidney endocrine axis that maintains phosphate homeostasis. When phosphate is in excess, fibroblast growth factor-23 (FGF23) is secreted from bone and acts on the kidney to promote phosphate excretion into urine and suppress vitamin D synthesis, thereby inducing negative phosphate balance.
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Clinical calcium, 2017
Fibroblast growth factor 23(FGF23)is produced mainly by osteocytes and works as a hormone that reduces serum phosphate level in a Klotho-dependent manner. The identification of FGF23 revealed that bone works as an endocrine organ. On the other hand, FGF23 has been shown to be high in patients with chronic kidney disease and suggested to cause several ...
openaire +1 more source
Fibroblast growth factor 23(FGF23)is produced mainly by osteocytes and works as a hormone that reduces serum phosphate level in a Klotho-dependent manner. The identification of FGF23 revealed that bone works as an endocrine organ. On the other hand, FGF23 has been shown to be high in patients with chronic kidney disease and suggested to cause several ...
openaire +1 more source
Determination of FGF23 Levels for the Diagnosis of FGF23-Mediated Hypophosphatemia
Journal of Bone and Mineral Research, 2022Pablo Florenzano Valdes +2 more
exaly
Proceedings of the National Academy of Sciences of the United States of America, 2010
Orson W. Moe +2 more
exaly
Orson W. Moe +2 more
exaly
Review for "Determination of FGF23 Levels for the Diagnosis of FGF23‐Mediated Hypophosphatemia"
2022openaire +2 more sources
Regulation of Phosphate Homeostasis by PTH, Vitamin D, and FGF23
Annual Review of Medicine, 2010Clemens Bergwitz
exaly