Results 171 to 180 of about 17,111 (223)

GLP-2 alleviates postmenopausal osteoporosis by acting on osteoblasts through the PI3K/AKT/FOXO1 signalling pathway to downregulate FGF23 expression. [PDF]

J Orthop Surg Res
Wu K, Ren W, Xu B, Shen J, Xu K, Hu Y.
europepmc   +1 more source

The effects of elevated phosphate on the kidney - damaging the gatekeeper. [PDF]

Pflugers Arch
Mitchell T, Verma V, Fajol A, Faul C.
europepmc   +1 more source

A phase 2 trial of burosumab for treatment of fibroblast growth factor-23-mediated hypophosphatemia in children and adults with fibrous dysplasia. [PDF]

Bone Res
de Jong O, Gun ZH, Asante-Otoo A, Elbashir II, Li X, Saboury B, Kram V, de Castro LF, MacDonald V, Boyce AM.   +9 more
europepmc   +1 more source

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FGF23 functions and disease

Minerva Endocrinology, 2023
The main function of fibroblast growth factor 23 (FGF23) is the regulation of phosphate metabolism through its action on the sodium-dependent phosphate cotransporters in the proximal renal tubules. Additionally, FGF23 interacts with vitamin D and parathyroid hormone in a complex metabolic pathway whose detailed mechanisms are still not clear in human ...
Cipriani, Cristiana, Minisola, Salvatore, Colangelo, Luciano, DE Martino, Viviana, Ferrone, Federica, Biamonte, Federica, Danese, Vittoria, Sonato, Chiara, Santori, Rachele, Occhiuto, Marco, Pepe, Jessica   +10 more
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FGF23 and the parathyroid glands

Pediatric Nephrology, 2010
Fibroblast growth factor 23 (FGF23) is a phosphatonin that is secreted by osteocytes and osteoblasts in response to hyperphosphatemia and 1,25-dihydroxyvitamin D (1,25D). It acts on its receptor complex, Klotho-FGFR1c (fibroblast growth factor receptor 1 c-splicing form), in the distal convoluted tubule to repress renal phosphorus reabsorption in the ...
Justin, Silver, Tally, Naveh-Many
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Structural asymmetry in FGF23 signaling

Trends in Pharmacological Sciences, 2023
Chen et al. have derived cryogenic electron microscopy (cryo-EM) structures of signaling complexes of the endocrine hormone fibroblast growth factor 23 (FGF23) with fibroblast growth factor receptor (FGFR), α-Klotho, and heparin sulfate. These structures are asymmetric, leading to questions concerning in vivo function, and will facilitate structure ...
Shih-Hsien Liu, Zhousheng Xiao, Jeremy C. Smith, L. Darryl Quarles   +3 more
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Extrarenal effects of FGF23

Pediatric Nephrology, 2016
Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular mortality, infections, and impaired cognitive function. It is characterized by excessively increased levels of the phosphaturic hormone fibroblast growth factor 23 (FGF23) and a deficiency of its co-receptor Klotho. Despite the important physiological effect of FGF23 in
Dieter, Haffner, Maren, Leifheit-Nestler
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FGF23 and the Parathyroid

2012
Klotho and fibroblast growth factor 1 (FGFR1) are expressed not only in FGF23's classical target organ, the kidney, but also in other organs such as the parathyroid. FGF23 acts on the parathyroid to decrease PTH mRNA and serum PTH levels. It does this by activating the MAPK pathway.
Justin, Silver, Tally, Naveh-Many
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FGF23 and Nutritional Metabolism

Annual Review of Nutrition, 2017
The discovery of fibroblast growth factor 23 (FGF23) has provided a more complete understanding of the regulation of phosphate and mineral homeostasis in health and in chronic kidney disease. It has also offered new insights into stratification of risk of cardiovascular events and death among patients with chronic kidney disease and the general ...
Lindsay R, Pool, Myles, Wolf
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