Results 181 to 190 of about 17,111 (223)
Some of the next articles are maybe not open access.
Annales d'Endocrinologie, 2021
FGF23 is a protein secreted in the plasma by bone cells. In the kidney, FGF23 can activate an FGF receptor in the presence of its co-receptor αKlotho. FGF23 controls the renal phosphate reabsorption and calcitriol metabolism. When renal function declines, plasma FGF23 concentration raises and FGF23 can stimulate FGFRs in the absence of αKlotho.
openaire +2 more sources
FGF23 is a protein secreted in the plasma by bone cells. In the kidney, FGF23 can activate an FGF receptor in the presence of its co-receptor αKlotho. FGF23 controls the renal phosphate reabsorption and calcitriol metabolism. When renal function declines, plasma FGF23 concentration raises and FGF23 can stimulate FGFRs in the absence of αKlotho.
openaire +2 more sources
AJP - Renal Physiology, 2021
The sodium-dependentphosphate co-transporters NaPi-IIa and NaPi-IIc located at the brush border membrane of renal proximal tubules are regulated by numerous factors, including fibroblast growth factor 23 (FGF23). FGF23 downregulates NaPi-IIa and NaPi-IIc
C. Küng +5 more
semanticscholar +1 more source
The sodium-dependentphosphate co-transporters NaPi-IIa and NaPi-IIc located at the brush border membrane of renal proximal tubules are regulated by numerous factors, including fibroblast growth factor 23 (FGF23). FGF23 downregulates NaPi-IIa and NaPi-IIc
C. Küng +5 more
semanticscholar +1 more source
Cardiac FGF23: new insights into the role and function of FGF23 after acute myocardial infarction
Cardiovascular Pathology, 2019We aimed to elucidate the local role of FGF23 after myocardial infarction in a mouse model induced by left anterior descending artery (LAD) ligation. APPROACH AND RESULTS: (C57BL/6 N) mice underwent MI via LAD ligation and were sacrificed at different time-points post MI.
Schumacher, David +12 more
openaire +2 more sources
Regulation and Effects of FGF23 in Chronic Kidney Disease.
Annual Review of Physiology, 2019Chronic kidney disease (CKD) is a global health epidemic that accelerates cardiovascular disease, increases risk of infection, and causes anemia and bone disease, among other complications that collectively increase risk of premature death.
J. Musgrove, M. Wolf
semanticscholar +1 more source
FGF23 is a hormone-regulating phosphate metabolism—Unique biological characteristics of FGF23
Bone, 2007FGF23 was identified as the last member of FGF23 family. Recent investigations indicate that excess actions of FGF23 cause several hypophosphatemic diseases whereas deficient FGF23 activity results in hyperphosphatemic tumoral calcinosis. These results indicate that FGF23 is a hormone that regulates serum phosphate level in contrast to other FGF family
Seiji, Fukumoto, Takeyoshi, Yamashita
openaire +2 more sources
Current Opinion in Nephrology and Hypertension, 2008
We aim to review the biological properties of novel molecules that are members of a kidney-bone axis involved in the regulation of phosphate homeostasis. In addition, we describe how an improved knowledge of the mechanisms leading to changes in renal phosphate handling may lead to the development of novel therapeutic approaches.As yet, eight genes ...
Tim M, Strom, Harald, Jüppner
openaire +2 more sources
We aim to review the biological properties of novel molecules that are members of a kidney-bone axis involved in the regulation of phosphate homeostasis. In addition, we describe how an improved knowledge of the mechanisms leading to changes in renal phosphate handling may lead to the development of novel therapeutic approaches.As yet, eight genes ...
Tim M, Strom, Harald, Jüppner
openaire +2 more sources
FGF23 and klotho at the intersection of kidney and cardiovascular disease
Nature Reviews Cardiology, 2023Daniel L. Edmonston, A. Grabner, M. Wolf
semanticscholar +1 more source
Regulation of FGF23 production and phosphate metabolism by bone–kidney interactions
Nature Reviews Nephrology, 2023Rafiou Agoro, K. White
semanticscholar +1 more source
FGF23 as a Novel Therapeutic Target
2012Fibroblast growth factor (FGF) 23 is a hormone that acts to decrease phosphate, 1,25-dihydroxyvitamin D and parathyroid hormone levels in circulation. Particularly, appropriate actions of FGF23 are essential for maintaining physiological phosphate and vitamin D metabolism. Therefore, either gain or loss of function of FGF23 can impair these homeostatic
Takashi, Shimada, Seiji, Fukumoto
openaire +2 more sources
FGF23 in Chronic Kidney Disease
2012Chronic kidney disease (CKD) is a growing public health epidemic that is associated with a markedly increased risk of cardiovascular mortality. Disordered mineral metabolism and particularly, disordered phosphorus metabolism appears to be a contributing factor. Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism.
Patricia, Wahl, Myles, Wolf
openaire +2 more sources