Results 191 to 200 of about 19,752 (209)
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2012
Klotho and fibroblast growth factor 1 (FGFR1) are expressed not only in FGF23's classical target organ, the kidney, but also in other organs such as the parathyroid. FGF23 acts on the parathyroid to decrease PTH mRNA and serum PTH levels. It does this by activating the MAPK pathway.
Justin, Silver, Tally, Naveh-Many
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Klotho and fibroblast growth factor 1 (FGFR1) are expressed not only in FGF23's classical target organ, the kidney, but also in other organs such as the parathyroid. FGF23 acts on the parathyroid to decrease PTH mRNA and serum PTH levels. It does this by activating the MAPK pathway.
Justin, Silver, Tally, Naveh-Many
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FGF23 associated bone diseases
Frontiers of Medicine, 2013Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential role in regulating phosphate and vitamin D metabolism. In this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin D metabolism, and the FGF23 related bone disease.
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FGF23 and the parathyroid glands
Pediatric Nephrology, 2010Fibroblast growth factor 23 (FGF23) is a phosphatonin that is secreted by osteocytes and osteoblasts in response to hyperphosphatemia and 1,25-dihydroxyvitamin D (1,25D). It acts on its receptor complex, Klotho-FGFR1c (fibroblast growth factor receptor 1 c-splicing form), in the distal convoluted tubule to repress renal phosphorus reabsorption in the ...
Justin, Silver, Tally, Naveh-Many
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Current Opinion in Nephrology and Hypertension, 2008
We aim to review the biological properties of novel molecules that are members of a kidney-bone axis involved in the regulation of phosphate homeostasis. In addition, we describe how an improved knowledge of the mechanisms leading to changes in renal phosphate handling may lead to the development of novel therapeutic approaches.As yet, eight genes ...
Tim M, Strom, Harald, Jüppner
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We aim to review the biological properties of novel molecules that are members of a kidney-bone axis involved in the regulation of phosphate homeostasis. In addition, we describe how an improved knowledge of the mechanisms leading to changes in renal phosphate handling may lead to the development of novel therapeutic approaches.As yet, eight genes ...
Tim M, Strom, Harald, Jüppner
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FGF23 in Chronic Kidney Disease
2012Chronic kidney disease (CKD) is a growing public health epidemic that is associated with a markedly increased risk of cardiovascular mortality. Disordered mineral metabolism and particularly, disordered phosphorus metabolism appears to be a contributing factor. Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism.
Patricia, Wahl, Myles, Wolf
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FGF23 is a hormone-regulating phosphate metabolism—Unique biological characteristics of FGF23
Bone, 2007FGF23 was identified as the last member of FGF23 family. Recent investigations indicate that excess actions of FGF23 cause several hypophosphatemic diseases whereas deficient FGF23 activity results in hyperphosphatemic tumoral calcinosis. These results indicate that FGF23 is a hormone that regulates serum phosphate level in contrast to other FGF family
Seiji, Fukumoto, Takeyoshi, Yamashita
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Annales d'Endocrinologie, 2015
Le Fibroblast Growth Factor 23 (FGF23) est une hormone peptidique secretee par les osteocytes et les osteoblastes. Il circule dans le plasma, sa concentration est comprise entre 10 a 50 pg/mL. Son role physiologique est de controler la concentration plasmatique de phosphate, et peut etre le contenu intracellulaire en phosphate, et la concentration de ...
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Le Fibroblast Growth Factor 23 (FGF23) est une hormone peptidique secretee par les osteocytes et les osteoblastes. Il circule dans le plasma, sa concentration est comprise entre 10 a 50 pg/mL. Son role physiologique est de controler la concentration plasmatique de phosphate, et peut etre le contenu intracellulaire en phosphate, et la concentration de ...
openaire +1 more source
Cardiac FGF23: new insights into the role and function of FGF23 after acute myocardial infarction
Cardiovascular Pathology, 2019We aimed to elucidate the local role of FGF23 after myocardial infarction in a mouse model induced by left anterior descending artery (LAD) ligation. APPROACH AND RESULTS: (C57BL/6 N) mice underwent MI via LAD ligation and were sacrificed at different time-points post MI.
Schumacher, David +12 more
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2021
During the evolution of skeletons, vertebrates acquired the bone made of calcium phosphate. By keeping the extracellular fluid in a supersaturated condition regarding calcium and phosphate, vertebrates create the bone when and where they want simply by providing a cue for precipitation.
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During the evolution of skeletons, vertebrates acquired the bone made of calcium phosphate. By keeping the extracellular fluid in a supersaturated condition regarding calcium and phosphate, vertebrates create the bone when and where they want simply by providing a cue for precipitation.
openaire +2 more sources