Results 51 to 60 of about 17,111 (223)

FGF23 directly inhibits osteoprogenitor differentiation in Dmp1-knockout mice

JCI Insight, 2023
Fibroblast growth factor 23 (FGF23) is a phosphate-regulating (Pi-regulating) hormone produced by bone. Hereditary hypophosphatemic disorders are associated with FGF23 excess, impaired skeletal growth, and osteomalacia. Blocking FGF23 became an effective
Guillaume Courbon, Dominik Kentrup, Jane Joy Thomas, Xueyan Wang, Hao-Hsuan Tsai, Jadeah Spindler, John Von Drasek, Laura Mazudie Ndjonko, Marta Martinez-Calle, Sana Lynch, Lauriane Hivert, Xiaofang Wang, Wenhan Chang, Jian Q. Feng, Valentin David, Aline Martin   +15 more
doaj   +1 more source

FGF23 expression in rodents is directly induced via erythropoietin after inhibition of hypoxia inducible factor proline hydroxylase. [PDF]

PLoS ONE, 2017
Plasma levels of FGF23 are increased in patients with chronic kidney disease. Beside its role in phosphate homeostasis, iron deficiency and anemia are associated with increased FGF23 plasma levels. Recently, FGF23 plasma levels were shown to be increased
Ingo Flamme, Peter Ellinghaus, Diana Urrego, Thilo Krüger   +3 more
doaj   +1 more source

The HIF-PHI BAY 85–3934 (Molidustat) Improves Anemia and Is Associated With Reduced Levels of Circulating FGF23 in a CKD Mouse Model

Journal of Bone and Mineral Research, 2021
Fibroblast growth factor‐23 (FGF23) is a critical factor in chronic kidney disease (CKD), with elevated levels causing alterations in mineral metabolism and increased odds for mortality.
Megan L. Noonan, Pu Ni, Rafiou Agoro, Spencer A Sacks, Elizabeth A. Swallow, Jonathan A. Wheeler, Erica L Clinkenbeard, M. Capitano, M. Prideaux, G. Atkins, W. R. Thompson, M. Allen, H. Broxmeyer, K. White   +13 more
semanticscholar   +1 more source

Phosphaturic mesenchymal tumor: Clinicopathological features with outcomes in 10 patients with review of literature

Indian Journal of Pathology and Microbiology
Background: Phosphaturic mesenchymal tumors (PMTs) are rare mesenchymal tumors, associated with long-standing, non-specific but often debilitating symptoms in the affected patients.
Vivek C. Parameshwar, Bharat Rekhi, Ashwini Duggad, Mukta Ramadwar   +3 more
doaj   +1 more source

Physiological Actions of Fibroblast Growth Factor-23

Frontiers in Endocrinology, 2018
Fibroblast growth factor-23 (FGF23) is a bone-derived hormone suppressing phosphate reabsorption and vitamin D hormone synthesis in the kidney. At physiological concentrations of the hormone, the endocrine actions of FGF23 in the kidney are αKlotho ...
Reinhold G. Erben
doaj   +1 more source

Should We Consider the Cardiovascular System While Evaluating CKD-MBD?

Toxins, 2020
Cardiovascular (CV) disease is highly prevalent in the population with chronic kidney disease (CKD), where the risk of CV death in early stages far exceeds the risk of progression to dialysis.
Merita Rroji, Andreja Figurek, Goce Spasovski   +2 more
doaj   +1 more source

A comparative transcriptome analysis identifying FGF23 regulated genes in the kidney of a mouse CKD model. [PDF]

PLoS ONE, 2012
Elevations of circulating Fibroblast growth factor 23 (FGF23) are associated with adverse cardiovascular outcomes and progression of renal failure in chronic kidney disease (CKD).
Bing Dai, Valentin David, Aline Martin, Jinsong Huang, Hua Li, Yan Jiao, Weikuan Gu, L Darryl Quarles   +7 more
doaj   +1 more source

αKlotho is a Non-Enzymatic Molecular Scaffold for FGF23 Hormone Signaling

Nature, 2018
The ageing suppressor α-klotho binds to the fibroblast growth factor receptor (FGFR). This commits FGFR to respond to FGF23, a key hormone in the regulation of mineral ion and vitamin D homeostasis. The role and mechanism of this co-receptor are unknown.
Gaozhi Chen, Yang Liu, R. Goetz, Li-li Fu, S. Jayaraman, M. Hu, O. Moe, G. Liang, Xiaokun Li, M. Mohammadi   +9 more
semanticscholar   +1 more source

Physiology of FGF23 and overview of genetic diseases associated with renal phosphate wasting.

Metabolism: Clinical and Experimental, 2020
Phosphate is a cornerstone of several physiological pathways including skeletal development, bone mineralization, membrane composition, nucleotide structure, maintenance of plasma pH, and cellular signaling.
J. Bacchetta, C. Bardet, D. Prié
semanticscholar   +1 more source

Vitamin D Actions: The Lung Is a Major Target for Vitamin D, FGF23, and Klotho

JBMR Plus, 2021
Vitamin D is well known for its role as a calcium regulator and in maintenance of phosphate homeostasis in musculoskeletal health, and fibroblast growth factor 23 (FGF23) and its coreceptor α‐klotho are known for their roles as regulators of serum ...
G. Gayan-Ramirez, W. Janssens
semanticscholar   +1 more source