Results 141 to 150 of about 37,073 (238)

Synergic activity of FGFR2 and MEK inhibitors in the treatment of FGFR2-amplified cancers of unknown primary

Molecular Therapy
Patients with cancer of unknown primary (CUP) carry the double burden of an aggressive disease and reduced access to therapies. Experimental models are pivotal for CUP biology investigation and drug testing. We derived two CUP cell lines (CUP#55 and #96) and corresponding patient-derived xenografts (PDXs), from ascites tumor cells.
Cavazzoni A., Salamon I., Fumarola C., Gallerani G., Laprovitera N., Gelsomino F., Riefolo M., Rihawi K., Porcellini E., Rossi T., Mazzeschi M., Naddeo M., Serravalle S., Broseghini E., Agostinis F., Deas O., Roncarati R., Durante G., Pace I., Lauriola M., Garajova I., Calin G. A., Bonafe M., D'Errico A., Petronini P. G., Cairo S., Ardizzoni A., Sales G., Ferracin M.   +28 more
openaire   +7 more sources

Primers used for genotyping FGFR2 SNPs.

, 2014
Primers used for genotyping FGFR2 SNPs.
Shilpi Chattopadhyay (647583), Md. Salman Akhtar (647584), Syed Akhtar Husain (86737), N. K. Shukla (647587), Sarah Siddiqui (647582), S. V. S. Deo (647586), Mohammad Zeeshan Najm (647585)   +6 more
core   +1 more source

The Role of FGFR2 as a Novel Biomarker for Treatment of Gastric Cancer—A Literature Review

Medicina
Background: Gastric cancer currently has the third highest mortality rate worldwide among cancer types. Despite gradual declines in mortality rates attributed to improvements in early detection and treatment, outcomes for advanced-stage disease are still
João Lages dos Santos, Rui Caetano Oliveira, João Martins Gama   +2 more
doaj   +1 more source

Antitumor activity of Tasurgratinib as an orally available FGFR1-3 inhibitor in Cholangiocarcinoma models with FGFR2-fusion [PDF]

Background/aim: Cholangiocarcinoma (CCA) is an aggressive tumor with limited treatment options especially in 2nd line or later treatments. Targeting fibroblast growth factor receptor (FGFR) 2 has recently emerged as a promising treatment option for ...
Fukushima, Sayo (author), Miyano, Saori Watanabe (author), Arai, Yasuhito (author), Kawada, Megumi Ikemori (author), Kawano, Satoshi (author), Shibata, Tatsuhiro (author)   +5 more
core   +1 more source

Cancer genomics and genetics of FGFR2 (Review)

International Journal of Oncology, 1992
FGFR2 gene encodes FGFR2b in epithelial cells, and FGFR2c in mesenchymal cells. FGFR2b is a high affinity receptor for FGF1, FGF3, FGF7, FGF10 and FGF22, while FGFR2c for FGF1, FGF2, FGF4, FGF6, FGF9, FGF16 and FGF20. Here genomics and genetics of FGFR2, and therapeutics targeted to FGFR2 will be reviewed.
openaire   +3 more sources

Abstract 1770: Overexpression of fibroblast growth factor receptor 2 (FGFR2) in gastric cancer and basis for future FGFR2-targeted cancer therapy

, 2010
Introduction: Fibroblast growth factors (FGFs) are potent mitogens and inducers of angiogenesis. FGF signalling pathway is closely associated with cancer development and progression.
Chiu-Hua Kao, Kun-Huei Yeh, Ann-Lii Cheng, Chia-Tung Shun, Yu-Lin Lin, Ying-Chun Shen   +5 more
core   +1 more source

A 58‐year‐old woman experiencing occasional dizziness, impaired awareness, and deep feeling of fear

Brain Pathology, Volume 36, Issue 6, November 2026.
Alessandro Selvaggini, Sabrina Rossi, Marco Brollo, Sabina Barresi, Laurino Licia, Lorenzo Nicolè   +5 more
wiley   +1 more source

The Prognostic Significance and Co-Expression of Fibroblast Growth Factor Receptor 2 and c-Met in Endometrial Cancer

International Journal of Women's Health
Huiqiao Gao, Qi Lu, Jianxin Zhang Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital Affiliated to Capital Medical University, Beijing, 100020, People’s Republic of ChinaCorrespondence: Jianxin Zhang, Email Jianxin20241031@126 ...
Gao H, Lu Q, Zhang J
doaj  

FGFR2 Positive [PDF]

, 2020
openaire   +1 more source

FGFR2 Gene [PDF]

, 2020
openaire   +1 more source