Results 131 to 140 of about 37,073 (238)
Thoracic Cancer, Volume 17, Issue 21, November 2026.This single‐center outcome study of prospectively identified pediatric congenital lung malformations and concurrent retrospective incidence in adult mucinous carcinoma found that in children with CLMs no resected malignant lesions could be identified on medium‐term follow‐up.
Medha Sridhar Rao +8 more
wiley +1 more source
Frontiers in OncologyFibroblast growth factor receptor 2 (FGFR2) alterations represent an emerging therapeutic target in gastroesophageal adenocarcinoma (GEA). Although FGFR2 amplifications and overexpression have been associated with poor prognosis and therapeutic ...
Eric Mehlhaff +9 more
doaj +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
, 2014 Transcripts and hypothetical protein products are modeled to illustrate the potential functional impact of fusion events involving FGFR2 (A–C). The identified fusion events involving MGEA5 (patient 4) (A) and BICC1 (patient 5, reciprocal event) (C) are ...
Asha A. Nair (160037) +48 more
core +1 more source
The FASEB Journal, Volume 40, Issue 20, 31 October 2026.A maternal western diet (WD) and betaine supplementation during suckling influence metabolic programming. A maternal WD induced adverse metabolic effects in offspring, accompanied by altered FGF21‐related gene expression and decreased Akkermansia muciniphila abundance.
Rocío A. Martín‐Chamorro +4 more
wiley +1 more source
MPI knockdown restored FGFR2 membrane localization.
, 2014 The localization of EGFR and FGFR2 was analyzed by confocal immunofluorescence microscopy in U-251 scramble and MPI shRNA cell lines. EGFR (red) and FGFR2 (green) membrane localization was determined for each sample.
Aurélie Cazet (644004) +4 more
core +1 more source
Cancer, Volume 132, Issue 20, 15 October 2026.Abstract Background Reliable prognostic biomarkers for treatment response in patients with biliary tract cancer (BTC) who receive chemoimmunotherapy are still lacking. The objective of this study was to evaluate the potential of early C‐reactive protein (CRP) kinetics as a tool for predicting survival in these patients.
Gabriel Allo +19 more
wiley +1 more source
Síndrome de Apert, una aproximación para un diagnóstico clínico. Reporte de caso
Salud Uninorte, 2010 Introducción: El síndrome de Apert, o acrocefalosindactilia tipo I, es un síndrome caracterizado por craneosinostosis, acompañada de sindactilia simétrica en las cuatro extremidades, alteraciones maxilofaciales, cutáneas y retardo mental variable.
Diana Ramírez +3 more
doaj
ChemMedChem, Volume 21, Issue 19, 14 October 2026.A series of diethylene glycol‐linked cyclic derivatives with diversity in the heterocyclic motif have been synthesized and screened for antitumor activity. Two bis‐thiazolo[3,2‐a]pyrimidinone derivatives displayed moderate cytotoxicity, high selectivity against hepatocellular carcinoma cells, promising VEGFR2, and remarkable FGFR2 inhibitory activities
Sami A. Al‐Hussain +6 more
wiley +1 more source
FGFR2 inhibition sensitizes cells to erlotinib in a cell specific manner.
, 2015 Cells were treated with 0.1μM and 1μM FGFR2 inhibitor AZD4547, or transfected with siRNA-FGFR2 construct, exposed to the indicated doses of erlotinib, and assessed for viability using the SRB assay.
Veerabhadran Baladandayuthapani (170016) +16 more
core +1 more source