Results 111 to 120 of about 37,073 (238)

Modulation of sebocyte function in acne: A pathway‐inclusive review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Acne is multifactorial, with the sebocyte acting as a central immunometabolic hub linking lipogenic, inflammatory, hormonal and barrier pathways. Mapping established and investigational therapies onto this sebocyte‐centred model offers a mechanism‐based framework that complements existing treatment paradigms and may guide more targeted, antibiotic ...
Christos C. Zouboulis, Apostolos Pappas, Katja Martin, Mauro Picardo   +3 more
wiley   +1 more source

Human Breast TICs Were Enriched in FGFR2+ Population that Was Sufficient to Initiate Tumor Growth.

, 2013
(A) The expression levels of FGFR2 mRNA in patient-derived breast tumors. Quantitative real-time PCR was performed using cDNA generated from RNA isolated from 26 primary human breast cancer specimens. cDNA isolated from a normal breast tissue was used to
John R. Walker (105748), Sungeun Kim (105743), Richard J. Salamone (105747), Venkateshwar A. Reddy (38510), Anthony P. Orth (105751), Carlos Garcia-Echeverria (92515), Anna Dubrovska (105746), Ghislain M. C. Bonamy (105750), Diana Graus Porta (105754), Jimmy Elliott (105752), Kathryn B. Grandinetti (105749)   +10 more
core   +1 more source

Generalized Comedones, Acne, and Hidradenitis Suppurativa in a Patient with an FGFR2 Missense Mutation [PDF]

, 2017
Mutations in the fibroblast growth factor-receptor gene 2 (FGFR2) gene have been implicated in numerous diseases, including nevus comedonicus (NC) and naevoid acne that have somatic missense mutations in FGFR2 in the affected tissue.
Nikhil Yawalkar, Rebecca Higgins, Higgins, Rebecca, Hunger, Robert, Navarini, Alexander A, Andrew Pink, Pink, Andrew, Yawalkar, Nikhil, Robert Hunger, Alexander A. Navarini, Navarini, Alexander A., Navarini AA, Higgins R, Pink A, Yawalkar N, Hunger R   +15 more
core   +2 more sources

When Virchow's law fails: Crouzon syndrome as a test case for quantitative suture closure–endocranial shape relationships

Journal of Anatomy, EarlyView.
Crouzon syndrome shows preserved intracranial volume but profoundly altered endocranial shape, with disrupted allometric coupling relative to controls. Treating calvarial suture patency as a continuous, age‐adjusted variable reveals strong system‐level covariation with endocranial morphology, effects invisible to conventional categorical suture scoring.
F. W. R. Steup, E. V. Groenenboom, O. Delassus, A. Balzeau, A. Profico, G. Paternoster, M. Moazen, R. H. Khonsari, L. S. Van De Lande, M. Taverne   +9 more
wiley   +1 more source

The N550K/H Mutations in FGFR2 Confer Differential Resistance to PD173074, Dovitinib, and Ponatinib ATP-Competitive Inhibitors [PDF]

, 2013
We sought to identify fibroblast growth factor receptor 2 (FGFR2) kinase domain mutations that confer resistance to the pan-FGFR inhibitor, dovitinib, and explore the mechanism of action of the drug-resistant mutations.
Dehkhoda, Farhad, Moosa Mohammadi, Andreas Wortmann, Michael G Gartside, Loch, David, Pamela M Pollock, David Loch, Blais, Steven P., Chen, Huaibin, Huaibin Chen, Pollock, Pamela M., Sara A Byron, Farhad Dehkhoda, Mohammadi, Moosa, Byron, Sara A., Neubert, Thomas A., Gartside, Michael, Thomas A Neubert, Steven P Blais, Wortmann, Andreas   +19 more
core   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Identification of potent biparatopic antibodies targeting FGFR2 fusion–driven cholangiocarcinoma

The Journal of Clinical Investigation
Translocations involving FGFR2 gene fusions are common in cholangiocarcinoma and predict response to FGFR kinase inhibitors. However, response rates and durability are limited due to the emergence of resistance, typically involving FGFR2 kinase domain ...
Saireudee Chaturantabut, Sydney Oliver, Dennie T. Frederick, Jiwan J. Kim, Foxy P. Robinson, Alessandro Sinopoli, Tian-Yu Song, Yao He, Yuan-Chen Chang, Diego J. Rodriguez, Liang Chang, Devishi Kesar, Meilani Ching, Ruvimbo Dzvurumi, Adel Atari, Yuen-Yi Tseng, Nabeel Bardeesy, William R. Sellers   +17 more
doaj   +1 more source

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

Synthesis and Evaluation of Novel ^99mTc-Labeled FGFR2-Targeting Peptides

To develop radiolabeled FGFR2-targeting probes for visualizing fibroblast growth factor receptor (FGFR) expression levels in the tumor microenvironment, four novel 99mTc-labeled FGFR2-targeting peptides ([99mTc]­Tc-FGFR2-1, [99mTc]­Tc-FGFR2-2, [99mTc]­Tc-
Jiaying Peng (14421216), Hao Luo (454719), Jingjing Yao (1411795), Mingxuan Fan (17729359), Jie Lu (139953)   +4 more
core   +1 more source

Change‐of‐function fibroblast growth factor receptor 3 mutations causing skeletal dysplasias

Journal of Cell Communication and Signaling, Volume 20, Issue 4, December 2026.
We show that the ligands FGF1 and FGF2 elicit differential fibroblast growth factor receptor 3 (FGFR3) signaling responses and that the FGFR3 G380R and A391E mutations reshape these signaling outputs. Thus, pathogenic FGFR3 mutations found in skeletal dysplasia do not simply enhance signaling strength and should be reclassified from “gain‐of‐function ...
Tanaya Roy, Zuzana Feketova, Jiawei Liu, Pavel Krejci, Kalina Hristova   +4 more
wiley   +1 more source