Results 101 to 110 of about 37,073 (238)

Drug-sensitive FGFR2 mutations in endometrial carcinoma.

, 2008
Oncogenic activation of tyrosine kinases is a common mechanism of carcinogenesis and, given the druggable nature of these enzymes, an attractive target for anticancer therapy.
Hanna, Megan, Akslen, Lars A, Dutt, Amit, Winckler, Wendy, Wyhs, Nicolas, Stefansson, Ingunn M, Salvesen, Helga B, Chen, Tzu-Hsiu, Fennell, Tim, Ziaugra, Liuda, Greulich, Heidi, Sellers, William R, Onofrio, Robert C, Richter, Daniel J, Trovik, Jone, Zody, Michael C, Hatton, Charlie, Grewal, Rupinder, Wong, Kwok-Kin, Zody, Michael C.,, Gabriel, Stacey, Sellers, William, Cibulskis, Kristian, Meyerson, Matthew, Engelsen, Ingeborg B, Ramos, Alex H, Nicoletti, Richard   +26 more
core   +1 more source

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity [PDF]

, 2013
Constitutive receptor tyrosine kinase phosphorylation requires regulation of kinase and phosphatase activity to prevent aberrant signal transduction. A dynamic mechanism is described here in which the adaptor protein, growth factor receptor–bound protein
Suen, Kin M., Zamal Ahmed, Melo, FA, Zamal Ahmed, Suhling, K, Ladbury, John E., Chi-Chuan Lin, Lin, Chi Chuan, Kin M. Suen, Lin, C-C, John E. Ladbury, James A Levitt, Klaus Suhling, Ahmed, Z, Ahmed, Zamal, Levitt, James A., Fernando A. Melo, Suen, KM, Melo, Fernando A., Levitt, JA, Ladbury, JE, Suhling, Klaus   +21 more
core   +1 more source

FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development

Biology Open, 2023
James F. Clark, Philippe Soriano
doaj   +1 more source

Blocking SHP2 benefits FGFR2 inhibitor and overcomes its resistance in FGFR2-amplified gastric cancer

eLife
Fibroblast growth factor receptor 2 (FGFR2) is an important member of receptor tyrosine kinase (RTK) family. FGFR2 amplification occurs at a high frequency in gastric cancer (GC) and has been proven to be closely associated with poor prognosis and ...
Yue Zhang, Hanbing Wang, Yutao Wei, Yunfeng Pan, Xueru Song, Jie Shao, Lixia Yu, Tao Shi, Yue Wang   +8 more
doaj   +1 more source

Temporospatial Expression of Fgfr1 and 2 During Lung Development, Homeostasis, and Regeneration

Frontiers in Pharmacology, 2020
Fgfr1 (Fibroblast growth factor receptor 1) and Fgfr2 are dynamically expressed during lung development, homeostasis, and regeneration. Our current analysis indicates that Fgfr2 is expressed in distal epithelial progenitors AT2, AT1, club, and basal ...
Tingting Yuan, Kylie Klinkhammer, Handeng Lyu, Handeng Lyu, Shan Gao, Jie Yuan, Seantel Hopkins, Jin-San Zhang, Stijn P. De Langhe   +8 more
doaj   +1 more source

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source

Activating FGFR2 breast cancer mutations.

, 2013
A) Representative Western blot showing increased tyrosine kinase activities of FGFR2-IIIb breast cancer mutants compared to tyrosine kinase activities of wt FGFR2-IIIb (WT), of a kinase defective (KD) FGFR2-IIIb mutant, and of a Pfeiffer syndrome gain-of-
Bernd Wollnik (365199), Nadine Reintjes (392059), Edyta Rohmann (392061), Rita Schmutzler (392062), Yun Li (692280), Alexandra Becker (392060)   +5 more
core   +1 more source

Identifizierung von Genen, die durch fibroblast growth factor receptor 2 (FGFR2) reguliert werden [PDF]

, 2001
FGF-Rezeptoren sind an der Regulation zahlreicher physiologischer Vorgänge beteiligt. Weiterhin können Mutationen in den Genen fürFGFR1, FGFR2 und FGFR3 zu autosomal-dominant vererbten Craniosynostosesyndromen führen.
Wagner, Andreas
core   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Poorly differentiated lung adenocarcinomas with concurrent ALK and CD30 expression: a diagnostic pitfall mimicking ALK‐positive anaplastic large‐cell lymphoma

Histopathology, EarlyView.
Poorly differentiated lung adenocarcinomas with concurrent anaplastic lymphoma kinase (ALK) and CD30 expression closely mimic ALK‐positive anaplastic large‐cell lymphoma, creating a significant diagnostic pitfall. Accurate classification requires comprehensive integration of clinical, radiologic, morphologic, immunophenotypic and molecular findings ...
Jietian Jin, Wenjian Cen, Qin Yan, Yangshan Chen, Chaoyun Huang, Yanfeng Feng, Neng Jiang   +6 more
wiley   +1 more source