Results 101 to 110 of about 45,688 (235)

Global isoform-specific transcript alterations and deregulated networks in clear cell renal cell carcinoma. [PDF]

, 2018
Extensive genome-wide analyses of deregulated gene expression have now been performed for many types of cancer. However, most studies have focused on deregulation at the gene-level, which may overlook the alterations of specific transcripts for a given ...
Girke, Thomas, Hamilton, Michael J, Martinez, Ernest   +2 more
core   +1 more source

A 58‐year‐old woman experiencing occasional dizziness, impaired awareness, and deep feeling of fear

Brain Pathology, EarlyView.
Alessandro Selvaggini, Sabrina Rossi, Marco Brollo, Sabina Barresi, Laurino Licia, Lorenzo Nicolè   +5 more
wiley   +1 more source

TNMplot: An enhanced platform for pharmacological target identification through cross‐stage and pan‐cancer gene expression analysis

British Journal of Pharmacology, Volume 183, Issue 11, Page 2648-2659, June 2026.
TNMplot.com, a web‐based platform integrating RNA‐Seq and gene‐chip data from 56,938 samples, enables differential gene expression analysis across normal, primary tumour and metastatic tissues, facilitating large‐scale transcriptomic profiling across 22 tumour types.
Áron Bartha, Balázs Győrffy
wiley   +1 more source

Next-generation sequencing of prostate cancer: genomic and pathway alterations, potential actionability patterns, and relative rate of use of clinical-grade testing. [PDF]

, 2019
Despite being one of the most common cancers, treatment options for prostate cancer are limited. Novel approaches for advanced disease are needed. We evaluated the relative rate of use of clinical-grade next generation sequencing (NGS) in prostate cancer,
Carter, Jennifer L, Elkin, Sheryl K, Ikeda, Sadakatsu, Kurzrock, Razelle, Tomson, Brett N   +4 more
core  

Intronic Single Nucleotide Polymorphisms in FGFR2 Gene Association With Non‐Syndromic Mandibular Retrognathism

Orthodontics &Craniofacial Research, Volume 29, Issue 3, Page 538-545, June 2026.
ABSTRACT Objective Mandibular retrognathism (MR) is a skeletal malocclusion in which patients have a deficient mandibular length, resulting in a more posterior position of the mandible. We aimed to investigate the association between Single nucleotide polymorphisms (SNPs) in Fibroblast Growth Factor Receptor 2 (FGFR2) gene and MR in germans.
Caio Luiz Bitencourt Reis, Christian Kirschneck, Daniel Hemming, Eva Paddenberg‐Schubert, Peter Proff, Daniela Silva Barroso de Oliveira, Cristiano Miranda de Araujo, Flares Baratto‐Filho, Svenja Beisel‐Memmert, Erika Calvano Küchler   +9 more
wiley   +1 more source

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. [PDF]

, 2019
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site ...
Abecasis, Goncalo, Alam, Dewan S, Alfred, Tamuno, Allison, Matthew, Amouyel, Philippe, Arzumanyan, Zorayr, Auer, Paul L, Balkau, Beverley, Bastarache, Lisa, Bergmann, Sven, Bielak, Lawrence F, Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Bork-Jensen, Jette, Bottinger, Erwin P, Bowden, Donald W, Brandslund, Ivan, Broer, Linda, Burt, Amber A, Butterworth, Adam S, Böger, Carsten A, Caulfield, Mark J, Cesana, Giancarlo, Chambers, John C, Chasman, Daniel I, Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y, Collins, Francis S, Cook, James P, Cox, Amanda J, Crosslin, David S, Danesh, John, de Bakker, Paul IW, Dedoussis, George, Demerath, Ellen W, Dennis, Joe G, Denny, Josh C, Denus, Simon de, Di Angelantonio, Emanuele, Drenos, Fotios, Dubé, Marie-Pierre, Dunning, Alison M, Dörr, Marcus, Easton, Douglas F, Elliott, Paul, Esko, Tõnu, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Feitosa, Mary F, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Fine, Rebecca S, Florez, Jose C, Fornage, Myriam, Fox, Caroline S, Franks, Paul W, Friedrich, Nele, Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Giri, Ayush, Girotto, Giorgia, Gorski, Mathias, Graff, Mariaelisa, Grallert, Harald, Grarup, Niels, Grove, Megan L, Guo, Xiuqing, Gustafsson, Stefan, Haessler, Jeff, Hansen, Torben, Hattersley, Andrew T, Heard-Costa, Nancy L, Highland, Heather M, Justice, Anne E, Karaderi, Tugce, Lempradl, Adelheid, Lo, Ken Sin, Locke, Adam E, Lu, Yingchang, Mahajan, Anubha, Manning, Alisa K, Marouli, Eirini, Medina-Gomez, Carolina, Mudgal, Poorva, Mutsert, Renée de, Ng, Maggie CY, Schurmann, Claudia, Sivapalaratnam, Suthesh, Turcot, Valérie, Vedantam, Sailaja, Willems, Sara M, Winkler, Thomas W, Young, Kristin L   +99 more
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, Volume 16, Issue 5, Page 979-999, May 2026.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The paradox of cancer genes in non-malignant conditions: implications for precision medicine. [PDF]

, 2020
Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures.
Adashek, Jacob J, Kato, Shumei, Kurzrock, Razelle, Lippman, Scott M   +3 more
core  

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Advanced Gastric Cancer Presenting as a Giant Subepithelial Lesion: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
A giant subepithelial lesion. ABSTRACT Gastric cancer may occasionally present with a subepithelial lesion‐like appearance. When a gastric gastrointestinal stromal tumor (GIST) is suspected preoperatively without definitive pathological confirmation, intraoperative frozen section analysis is recommended to prevent inappropriate surgical intervention.
Ji Sun, Qian Wang, Yuemei Hu, Ping Yin, Ziming Zhou, Hui Chen, Xiaoming Zhu   +6 more
wiley   +1 more source