Results 81 to 90 of about 37,073 (238)

Impact of Molecular Alterations on Survival in Biliary Tract Cancers: A Retrospective Belgian Cohort Study

International Journal of Cancer, EarlyView.
ABSTRACT Biliary tract cancers (BTCs) are aggressive malignancies associated with a poor prognosis. Although molecular profiling is recommended to guide therapeutic decision‐making, real‐practice data on the prevalence and prognostic significance of genomic alterations in European BTC cohorts remain limited.
Jorine Arnouts, Léon C. van Kempen, Senada Koljenović, Helena Oliveres, Pieterjan Vanclooster, Hans Prenen, Caro De Weerdt, Siddharth Chhajlani, Geert Roeyen, Laure Sorber, Koen De Winne, Jonas Dahnoun, Greetje Vanhoutte, Timon Vandamme, Karen Zwaenepoel   +14 more
wiley   +1 more source

Targeting extracellular and juxtamembrane FGFR2 mutations in chemotherapy-refractory cholangiocarcinoma

npj Precision Oncology, 2021
Intrahepatic cholangiocarcinoma (iCCA) has emerged as a promising candidate for precision medicine, especially in the case of activating FGFR2 gene fusions.
Michael Bitzer, Stephan Spahn, Sepideh Babaei, Marius Horger, Stephan Singer, Klaus Schulze-Osthoff, Pavlos Missios, Sergios Gatidis, Dominik Nann, Sven Mattern, Veit Scheble, Konstantin Nikolaou, Sorin Armeanu-Ebinger, Martin Schulze, Christopher Schroeder, Saskia Biskup, Janina Beha, Manfred Claassen, Kristina Ruhm, Antti Poso, Nisar P. Malek   +20 more
doaj   +1 more source

Recurrent FGFR2 and PIK3CA Mutations in Sialoblastoma

Head and Neck Pathology
Abstract Purpose Sialoblastoma is an extremely rare low-grade malignant salivary gland neoplasm that presents at birth or early infancy and has heterogeneous clinical behavior. Due to its rarity, the molecular landscape remains incompletely characterized.
Koo, Selene C., Ma, Jingqun, Tran, Quynh T., Alaggio, Rita, Stracuzzi, Alessandra, Chou, Pauline M., Wilkins, Benjamin J., Orr, Brent A., Malik, Faizan   +8 more
openaire   +3 more sources

Liquid biopsy across cancers: Integrating circulating biomarkers, tumor biology, artificial intelligence, and clinical translation

Interdisciplinary Medicine, EarlyView.
Liquid biopsy uses non‐invasive sampling of blood or body fluids to isolate circulating analytes, including circulating tumor DNA, circulating tumor cells, extracellular vesicles, and RNA. These are analyzed using next‐generation sequencing, qPCR, and proteomics to inform cancer detection, monitoring, and characterization. Figure created with BioRender.
Jaswinder Singh, Manjeet Kumar, Kajal Kamra   +2 more
wiley   +1 more source

Expression of Fgfr2 in E10.5 in control and Fgfr2^ST−/− embryos.

, 2013
A,C. Lower power (A) and higher power (C) images show that control embryos have a wide band of Fgfr2 signal (between arrowheads) encompassing the Wolffian duct and surrounding stroma. B,D.
Caitlin Schaefer (280685), Kenneth A. Walker (280683), Sunder Sims-Lucas (164492), Tatiana Novitskaya (280687), Feng Chen (25347), Whitney M. Sunseri (280686), Carlton M. Bates (280689), Valeria E. Di Giovanni (280684), Mark P. de Caestecker (280688)   +8 more
core   +1 more source

LncRNA SBF2-AS1 Promotes Diffuse Large B-Cell Lymphoma Growth by Regulating FGFR2 via Sponging miR-494-3p

Cancer Management and Research, 2021
Dong-Wei Fu, Ai-Chun Liu Department of Hematology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, People’s Republic of ChinaCorrespondence: Ai-Chun LiuDepartment of Hematology, Harbin Medical University, Cancer Hospital ...
Fu DW, Liu AC
doaj  

Mass Spectrometry‐Based Extracellular Vesicle Proteomics for Biomarker Discovery

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicle (EV) proteomics has emerged as a powerful platform for decoding intercellular communication and advancing biomarker discovery across human diseases. EVs carry proteins that reflect their cells of origin, offering a minimally invasive window into physiological and pathological processes.
Ya‐Juan Liu, Juan Peng, Chao Kang
wiley   +1 more source

FGFR2 interacts with IKKβ and stimulates tyrosine phosphorylation of IKKβ.

, 2013
FGFR2 wildtype (WT) or kinase dead (KD) and IKKβ were expressed in HEK293 cells. (A) FGFR2 associates with IKKβ. IKKβ was immunoprecipitated from lysates and analysed for FGFR2 by immunoblot (top panel).
Kristine A. Drafahl (234437), Leandro H. Gallo (502815), Martin Haas (102351), Laurence M. Brill (502816), April N. Meyer (234448), Jennifer E. Gilda (502814), Daniel J. Donoghue (234454), Christopher W. McAndrew (234440)   +7 more
core   +1 more source

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

FGFR2 protein expression in breast cancer: nuclear localisation and correlation with patient genotype

BMC Research Notes, 2011
Background Single Nucleotide Polymorphisms (SNPs) in intron 2 of the Fibroblast Growth Factor Receptor Type 2 (FGFR2) gene, including rs2981582, contribute to multifactorial breast cancer susceptibility.
Thompson Alastair M, Purdie Colin A, Quinlan Philip R, Baker Lee, Palmer Colin N, Ashfield Alison M, Grant Andrew, Martin Amy J, Jordan Lee B, Berg Jonathan N   +9 more
doaj   +1 more source