Results 61 to 70 of about 45,688 (235)

532 Evaluating fibroblast growth factor receptor (FGFR) pathway mRNA expression and protein activation in cholangiocarcinoma tumors

Journal of Clinical and Translational Science
Objectives/Goals: Personalized cancer therapy based on genomic testing is advancing patient care. Genomic alterations in fibroblast growth factor receptor (FGFR) predict response to FGFR inhibitors; however, the role of RNA expression and protein ...
Leah Stein, Julie W. Reeser, Michele R. Wing, Eric Samorodnitsky, Anoosha Paruchuri, Amy Smith, Thuy Dao, Zachary Risch, Emanuel F. Petricoin, Sameek Roychowdhury   +9 more
doaj   +1 more source

Subcellular localization of fibroblast growth factor receptor type 2 and correlation with CTNNB1 genotype in adrenocortical carcinoma

BMC Research Notes, 2020
Objective Fibroblast growth factor receptor (FGFR) 2 regulates the development of the adrenal gland in mice. In addition, FGFR2-mediated signalling has been shown to prevent apoptosis and to enhance proliferation in adrenocortical precursor cells.
Matthias Haase, Anne Thiel, Ute I. Scholl, Hany Ashmawy, Matthias Schott, Margret Ehlers   +5 more
doaj   +1 more source

Fibroblast growth factor receptor 2 (FGFR2) is required for corneal epithelial cell proliferation and differentiation during embryonic development. [PDF]

PLoS ONE, 2015
Fibroblast growth factors (FGFs) play important roles in many aspects of embryonic development. During eye development, the lens and corneal epithelium are derived from the same surface ectodermal tissue.
Jinglin Zhang, Dinesh Upadhya, Lin Lu, Lixing W Reneker   +3 more
doaj   +1 more source

FGFR2 Promotes Gastric Cancer Progression by Inhibiting the Expression of Thrombospondin4 via PI3K-Akt-Mtor Pathway

Cellular Physiology and Biochemistry, 2018
Background/Aims: Fibroblast growth factor receptor 2 (FGFR2) has attracted considerable interest as a therapeutic target in gastric cancer (GC). There is growing evidence to suggest that the bioavailability of the potent pro-tumor function of FGFR2 is ...
Tingting Huang, Dian Liu, Yihua Wang, Piao Li, Li Sun, Huihua Xiong, Yuhong Dai, Man Zou, Xianglin Yuan, Hong  Qiu   +9 more
doaj   +1 more source

Targeting extracellular and juxtamembrane FGFR2 mutations in chemotherapy-refractory cholangiocarcinoma

npj Precision Oncology, 2021
Intrahepatic cholangiocarcinoma (iCCA) has emerged as a promising candidate for precision medicine, especially in the case of activating FGFR2 gene fusions.
Michael Bitzer, Stephan Spahn, Sepideh Babaei, Marius Horger, Stephan Singer, Klaus Schulze-Osthoff, Pavlos Missios, Sergios Gatidis, Dominik Nann, Sven Mattern, Veit Scheble, Konstantin Nikolaou, Sorin Armeanu-Ebinger, Martin Schulze, Christopher Schroeder, Saskia Biskup, Janina Beha, Manfred Claassen, Kristina Ruhm, Antti Poso, Nisar P. Malek   +20 more
doaj   +1 more source

Fetal microtia and FGFR2 polymorphism

Experimental and Therapeutic Medicine, 2019
Association of the single-nucleotide polymorphism (SNP) of rs3135718 site in fibroblast growth factor receptor 2 (FGFR2) gene with congenital microtia was investigated. A total of 193 patients with congenital microtia (observation group) and 150 normal and healthy fetuses (control group) treated in Maternity and Child Health Care of Zaozhuang from ...
Zhao, Ruilian, Du, Peixia, Sun, Hongmei, Yang, Li, Lin, Pingzhen   +4 more
openaire   +3 more sources

Activated FGFR2 signalling as a biomarker for selection of intrahepatic cholangiocarcinoma patients candidate to FGFR targeted therapies

Scientific Reports
FGFR inhibitors have been developed to inhibit FGFR activation and signal transduction; notwithstanding, currently the selection of intrahepatic cholangiocarcinoma (iCCA) patients for these drugs only relies on the detection of FGFR2 genetic alterations (
Giovanni Brandi, Valeria Relli, Marzia Deserti, Andrea Palloni, Valentina Indio, Annalisa Astolfi, Salvatore Serravalle, Alessandro Mattiaccio, Francesco Vasuri, Deborah Malvi, Chiara Deiana, Maria Abbondanza Pantaleo, Matteo Cescon, Alessandro Rizzo, Masaru Katoh, Simona Tavolari   +15 more
doaj   +1 more source

FGFR2 protein expression in breast cancer: nuclear localisation and correlation with patient genotype

BMC Research Notes, 2011
Background Single Nucleotide Polymorphisms (SNPs) in intron 2 of the Fibroblast Growth Factor Receptor Type 2 (FGFR2) gene, including rs2981582, contribute to multifactorial breast cancer susceptibility.
Thompson Alastair M, Purdie Colin A, Quinlan Philip R, Baker Lee, Palmer Colin N, Ashfield Alison M, Grant Andrew, Martin Amy J, Jordan Lee B, Berg Jonathan N   +9 more
doaj   +1 more source

Inhibition of FGFR2 Signaling by Cynaroside Attenuates Liver Fibrosis

Pharmaceuticals, 2023
Liver fibrosis represents a significant health hazard with a high morbidity rate and an increased risk of liver cancer. Targeting overactivated Fibroblast growth factor receptor 2 (FGFR2) is a promising strategy to counteract collagen accumulation during
Qilin Meng, Lin Luo, Minghua Lei, Zhiqi Chen, Yuanmeng Sun, Xue Chen, Zhaodong Zhai, Yibo Zhang, Jieqiong Cao, Zijian Su, Fu Li, Jingsheng Li, An Hong, Xiaojia Chen   +13 more
doaj   +1 more source

Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers [PDF]

, 2014
Peer reviewedPublisher ...
Andrulis, Irene L, Arun, Banu K, Barrowdale, Daniel, Benitez, Javier, Breast Cancer Family Registry, Buys, Saundra S, Cass, Ilana, Cunningham, Julie, Daly, Mary B, Dennis, Joe, Domchek, Susan M, Dorfling, Cecilia M, Duran, Mercedes, Ejlertsen, Bent, Engel, Christoph, Gerdes, Anne-Marie, Goldgar, David E, Hart, Steven, Healey, Sue, James, Paul, Janavicius, Ramunas, Karlan, Beth Y, Kuchenbaecker, Karoline B, Lee, Andrew, Lester, Jenny, McGuffog, Lesley, Miedzybrodzka, Zofia Helena, Mulligan, Anna Marie, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Nielsen, Finn C, Nussbaum, Robert L, Osorio, Ana, Radice, Paolo, Ramus, Susan J, Rebbeck, Timothy R, Robson, Mark, Schmidt, Marjanka K, Schmutzler, Rita K, Slager, Susan, Southey, Melissa, Spurdle, Amanda B, Steele, Linda, Terry, Mary Beth, Thomassen, Mads, Tihomirova, Laima, Tung, Nadine, v O Hansen, Thomas, van Rensburg, Elizabeth J, Wappenschmidt, Barbara   +50 more
core   +3 more sources