Results 51 to 60 of about 37,073 (238)
Advanced Science, EarlyView.Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su +14 more
wiley +1 more source
Advanced Science, EarlyView.4D bioprinted hydrogel loaded with FGF2‐modified extracellular vesicles (4D@F‐EVs) targets dermal fibroblasts and elevates local wound FGF2 levels via sustained release of F‐EVs. It activates PI3K‐Akt signaling, restores critical KGF+ fibroblast–KGFR+ keratinocyte crosstalk, enhances robust angiogenesis and collagen deposition to efficiently repair ...
Xiaomin Wang +19 more
wiley +1 more source
Protein recruitment to receptor tyrosine kinase-mediated early signalling complexes. [PDF]
, 2007 Receptor tyrosine kinase (RTK) signalling regulates the activation of numerous cellular processes in response to various external stimuli. Spatio-temporal regulation of protein recruitment to activated tyrosine kinase receptors is important for the ...
Schller, A.C.
core
Novel FGFR2 fusion genes in MFM-223 mammary carcinoma cell line
, 2015 Novel FGFR2 fusion genes in MFM-223 mammary carcinoma cell line. The novel and novel fusion genes FGFR2-PVT1, MAP2K3-FGFR2, AIM1-FGFR2, SPECC1-FGFR2, and MAP2K3-PVT1 in MFM-223 mammary carcinoma cell line: FGFR2-PVT1FBXO28-IFI16PPP4R1-RALBP1DLG5 ...
Daniel Nicorici (101429)
core +1 more source
OncoTargets and Therapy, 2022 Fibroblast growth factor receptor (FGFR) fusions in non-small cell lung cancer (NSCLC) are small genomic events. At present, there is no standard treatment strategy for patients with NSCLC carrying an FGFR fusion.We report the case of a 45-year-old female patient who was diagnosed with lung adenocarcinoma and underwent right upper lobectomy and ...
Chen Hong +4 more
openaire +2 more sources
Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency
Advanced Science, EarlyView.How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen +10 more
wiley +1 more source
FGF and TGFbeta signalling in an in-vitro model of craniosynostosis [PDF]
, 2009 Fibroblast Growth Factor (FGF) and Transforming Growth Factor beta (TGFbeta) are key regulators of bone development. Constitutively activating mutations of FGF Receptors (FGFR) 1-3 result in craniosynostosis, premature fusion of cranial sutures.
Lee, K.M.A.
core
Novel FGFR2 fusion genes in KATOIII gastric cancer cell line
, 2013 Novel fusion genes in KATOIII gastric cancer cell line found using using FusionCatcher and RNA-seq data. The novel FGFR2 fusion genes (i.e.FGFR2-ULK4, FGFR2-CEACAM5, CTNNB1-FGFR2,GCNT3-FGFR2, SNX19-FGFR2) were found in KATOIII cell line.
Daniel Nicorici (101429)
core +1 more source
Journal of Oncology, 2022 Aberrations in the fibroblast growth factor receptor2 (FGFR2) gene, including genetic alterations and chromosomal rearrangements, lead to the development and progression of cancer with poor prognosis. However, the mechanisms underlying the FGFR2 signaling pathway to facilitate the development of FGFR2-targeted therapies have not been fully explored ...
Sujin Hyung +11 more
openaire +2 more sources
Advanced Science, EarlyView.During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum +13 more
wiley +1 more source