Results 31 to 40 of about 37,073 (238)
Genomic Alterations in Pulmonary Carcinoid Tumors: A Targeted Analysis of Gene Rearrangements and Oncogenic Mutations. [PDF]
Cancer MedThis study applied RNA‐based next‐generation sequencing to one of the largest cohorts of pulmonary carcinoid tumors analyzed to date and revealed rare yet potentially actionable gene rearrangements and variants, including alterations in ALK, BRAF, and EGFR.
Niinimäki J +4 more
europepmc +2 more sources
FGFR2 amplification in colorectal adenocarcinoma [PDF]
Molecular Case Studies, 2017 FGFR2 is recurrently amplified in 5% of gastric cancers and 1%–4% of breast cancers; however, this molecular alteration has never been reported in a primary colorectal cancer specimen. Preclinical studies indicate that several FGFR tyrosine-kinase inhibitors (TKIs), such as AZD4547, have in vitro activity against the FGFR2-amplified colorectal cell ...
Carter, Jamal H +6 more
openaire +3 more sources
FGFR2-related pathogenesis and FGFR2-targeted therapeutics (Review)
International Journal of Molecular Medicine, 2009 FGFR2 gene at human chromosome 10q26 encodes FGFR2b and FGFR2c isoforms functioning as FGF receptors with distinct expression domain and ligand specificity. FGFR2 plays oncogenic and anti-oncogenic roles in a context-dependent manner. Single nucleotide polymorphisms (SNPs) within intron 2 of FGFR2 gene are associated with breast cancer through allelic ...
Yuriko, Katoh, Masaru, Katoh
openaire +3 more sources
RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations [PDF]
, 2023 Oncogenic activation of fibroblast growth factor receptor 2 (FGFR2) drives multiple cancers and represents a broad therapeutic opportunity, yet selective targeting of FGFR2 has not been achieved. Although the clinical efficacy of pan-FGFR inhibitors (pan-
Maglic, Dejan (author) +92 more
core +1 more source
The roles of Fibroblast Growth Factor 22 in development, tissue repair and homeostasis, and the associated role of FGF signalling in skin cancer. [PDF]
, 2010 PhDFibroblast Growth Factors (FGFs) play critical roles during development, tissue homeostasis and repair and in controlling cell proliferation, survival, migration and differentiation.
Jarosz, Monika
core +2 more sources
Translational Psychiatry, 2023 Fibroblast growth factor receptor 2 (FGFR2) is almost exclusively expressed in glial cells in postnatal mouse brain, but its impact in glia for brain behavioral functioning is poorly understood.
Hanna E. Stevens +5 more
doaj +1 more source
Clinical and Experimental Hypertension, 2023 Background Fibroblast growth factor receptor (FGFR)2 expression was decreased in hypertension patients while its role in hypertension was not explored. This experiment aimed to investigate the expression ofFGFR2 in angiotensin II (Ang II)-induced human ...
Kun Jiao, Ping Su, Yongling Li
doaj +1 more source
, 2023 Supplementary Figure 2. Treatment with RLY-4008 is well-tolerated and leads to dose-dependent inhibition of FGFR2 and tumor regression in multiple FGFR2-altered tumor models.
Patrick J. O'Hearn (16616188) +30 more
core +3 more sources
Clinical Implication of Concurrent Amplification of MET and FGFR2 in Metastatic Gastric Cancer
Biomedicines, 2023 Background: c-mesenchymal epithelial transition factor receptor (c-MET) and fibroblast growth factor receptor 2 (FGFR2) amplification have been identified as factors associated with advanced stage and poor prognosis in gastric cancer (GC). While they are
Seonggyu Byeon +4 more
doaj +1 more source
FGFR2 as a molecular target in endometrial cancer [PDF]
, 2009 Although molecularly targeted therapies have been effective in some cancer types, no targeted therapy is approved for use in endometrial cancer.
Byron, Sara A., Pollock, Pamela M.
core +1 more source