Results 11 to 20 of about 37,073 (238)
FGFR2 overexpression and compromised survival in diffuse-type gastric cancer in a large central European cohort [PDF]
PLoS ONE, 2022 The significance of fibroblast growth factor receptor 2 (FGFR2) in gastric cancer (GC) has been studied predominantly in Asian patient cohorts. Data on White patients are scarce.
Thorben Schrumpf +4 more
doaj +3 more sources
Advanced Science, 2021 Fibroblast growth factor receptor 2 (FGFR2) is a membrane‐spanning tyrosine kinase that mediates FGF signaling. Various FGFR2 alterations are detected in breast cancer, yet it remains unclear if activation of FGFR2 signaling initiates tumor formation. In
Lin Chen, Chu-Xia Deng, Xiaoling Xu
exaly +2 more sources
FGFR2 signaling and the pathogenesis of acne [PDF]
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2008 SummaryAcne in Apert syndrome and unilateral segmental acneiform nevus are associated with mutations of fibroblast growth factor receptor 2 (FGFR2), which are likely to be involved in the pathogenesis of acne. Translational animal and cellular models, developmental biology studies and clinical observations have contributed to our understanding of FGF ...
Bodo, Melnik, Gerd, Schmitz
openaire +3 more sources
Activating somatic FGFR2 mutations in breast cancer. [PDF]
PLoS ONE, 2013 It is known that FGFR2 gene variations confer a risk for breast cancer. FGFR2 and FGF10, the main ligand of FGFR2, are both overexpressed in 5-10% of breast tumors.
Nadine Reintjes +5 more
doaj +2 more sources
Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway
Cells, 2019 Tight regulation of signaling from receptor tyrosine kinases is required for normal cellular functions and uncontrolled signaling can lead to cancer. Fibroblast growth factor receptor 2 (FGFR2) is a receptor tyrosine kinase that induces proliferation and
Ellen M Haugsten +2 more
exaly +3 more sources
Lower FGFR2 mRNA Expression and Higher Levels of FGFR2 IIIc in HER2-Positive Breast Cancer
BiologyFibroblast growth factor receptor 2 (FGFR2) has been associated with breast cancer. We performed in silico analyses to investigate the FGFR2 mRNA expression and splice variants associated with breast cancer subtypes.
Thérèse Dix-Peek +3 more
doaj +2 more sources
Discovery of a covalent FGFR2-selective inhibitor overcoming clinically-acquired resistance mutations [PDF]
Nature CommunicationsAbnormal activation of fibroblast growth factor receptor 2 (FGFR2) drives tumorigenesis in various cancers. Clinical use of pan-FGFR inhibitors is limited due to emerging acquired resistance mutations within the FGFR2 kinase domain and adverse effects ...
Xiaohao Huang +12 more
doaj +2 more sources
FGFR2 and favorable survival outcomes in resected poorly cohesive cell gastric cancer: Analysis from FGFR2 protein overexpression and genetic variation. [PDF]
PLoS ONEPurposePoorly cohesive cell gastric cancer has aggressive and heterogeneous characteristics. This study investigated the clinical significance of fibroblast growth factor receptor 2 expression and genetic variations in patients with PCC-GC.Materials and ...
Yun Ji Lee +9 more
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Design and synthesis of an erdafitinib-based selective FGFR2 degrader [PDF]
Beilstein Journal of Organic ChemistryThis study aimed to develop a novel degrader capable of selectively degrading fibroblast growth factor receptor 2 (FGFR2) to overcome the issues of drug resistance and adverse reactions associated with traditional inhibitors in the treatment of FGFR2 ...
Yumeng Jin +7 more
doaj +2 more sources
Cellular Physiology and Biochemistry, 2018 Background/Aims: Fibroblast growth factor receptor 2 (FGFR2) has attracted considerable interest as a therapeutic target in gastric cancer (GC). There is growing evidence to suggest that the bioavailability of the potent pro-tumor function of FGFR2 is ...
Yihua Wang, Li Sun, Xianglin Yuan
exaly +3 more sources