Results 11 to 20 of about 37,664 (239)

FGFR2 Inhibition in Cholangiocarcinoma.

Annual Review of Medicine, 2022
Biliary tract cancer (BTC) is the second most common primary liver cancer after hepatocellular carcinoma and accounts for 2% of cancer-related deaths. BTCs are classified according to their anatomical origin into intrahepatic (iCCA), perihilar, or distal
A. Vogel, O. Segatto, A. Stenzinger, A. Saborowski   +3 more
semanticscholar   +3 more sources

Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple‐Negative Mammary Tumorigenesis That is Sensitive to Immunotherapy

Advanced Science, 2021
Fibroblast growth factor receptor 2 (FGFR2) is a membrane‐spanning tyrosine kinase that mediates FGF signaling. Various FGFR2 alterations are detected in breast cancer, yet it remains unclear if activation of FGFR2 signaling initiates tumor formation. In
Josh Haipeng Lei, Mi‐Hye Lee, Kai Miao, Zebin Huang, Zhicheng Yao, Aiping Zhang, Jun Xu, Ming Zhao, Zenan Huang, Xin Zhang, Si Chen, NG Jiaying, Yuzhao Feng, Fuqiang Xing, Ping Chen, Heng Sun, Qiang Chen, Tingxiu Xiang, Lin Chen, Xiaoling Xu, Chu‐Xia Deng   +20 more
doaj   +2 more sources

Futibatinib for FGFR2-Rearranged Intrahepatic Cholangiocarcinoma.

New England Journal of Medicine, 2023
BACKGROUND Alterations in fibroblast growth factor receptor 2 (FGFR2) have emerged as promising drug targets for intrahepatic cholangiocarcinoma, a rare cancer with a poor prognosis.
L. Goyal, F. Meric-Bernstam, A. Hollebecque, J. Valle, C. Morizane, T. Karasic, T. Abrams, J. Furuse, R. Kelley, P. Cassier, H. Klümpen, H. Chang, Li-Tzong Chen, J. Tabernero, Do-Youn Oh, A. Mahipal, M. Moehler, E. Mitchell, Y. Komatsu, Kunihiro Masuda, Daniel H Ahn, R. Epstein, A. Halim, Yao Fu, T. Salimi, V. Wacheck, Yaohua He, Mei Liu, K. Benhadji, J. Bridgewater   +29 more
semanticscholar   +3 more sources

Neonatal loss of FGFR2 in astroglial cells affects locomotion, sociability, working memory, and glia-neuron interactions in mice

Translational Psychiatry, 2023
Fibroblast growth factor receptor 2 (FGFR2) is almost exclusively expressed in glial cells in postnatal mouse brain, but its impact in glia for brain behavioral functioning is poorly understood.
Hanna E. Stevens, Soraya Scuderi, Sarah C. Collica, Simone Tomasi, Tamas L. Horvath, Flora M. Vaccarino   +5 more
doaj   +2 more sources

2H-pyrazolo[3,4-d]pyrimidin-4-amine derivatives as novel selective fibroblast growth factor receptor 2 (FGFR2) inhibitors [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Although FGFR2 is a well-validated oncogenic target, no selective FGFR2 inhibitors have been approved for clinical use. In this study, we report the discovery of 2H-pyrazolo[3,4-d]pyrimidin-4-amine derivative as novel, irreversible FGFR2 inhibitors.
Pinglian Wu, Zhaodi Tian, Weizhong Shen, Qiuju Xun, Yuan Tian, Huiqiong Li, Bowen Yang, Shaohua Chang, Weixue Huang, Zhen Wang, Ke Ding, Dawei Ma   +11 more
doaj   +2 more sources

FGFR2 alterations in endometrial carcinoma [PDF]

Modern Pathology, 2011
Fibroblast growth factor receptor 2 (FGFR2) is a tyrosine kinase receptor involved in many biological processes such as embryogenesis, adult tissue homeostasis and cell proliferation. Mutations in FGFR2 have been reported in up to 10-12% of endometrial carcinomas identical to those found in congenital craniofacial disorders.
Xavier Matias-Guiu, Xavi Dolcet, Ana Velasco   +2 more
exaly   +4 more sources

Design and synthesis of an erdafitinib-based selective FGFR2 degrader [PDF]

Beilstein Journal of Organic Chemistry
This study aimed to develop a novel degrader capable of selectively degrading fibroblast growth factor receptor 2 (FGFR2) to overcome the issues of drug resistance and adverse reactions associated with traditional inhibitors in the treatment of FGFR2 ...
Yumeng Jin, Shidong Wang, Sihan Pan, Shuqi Huang, Weichen Zhou, Xiaohao Huang, Lei Zheng, Lingfeng Chen   +7 more
doaj   +2 more sources

FGFR2 overexpression and compromised survival in diffuse-type gastric cancer in a large central European cohort

PLoS ONE, 2022
The significance of fibroblast growth factor receptor 2 (FGFR2) in gastric cancer (GC) has been studied predominantly in Asian patient cohorts. Data on White patients are scarce.
Thorben Schrumpf, Hans-Michael Behrens, Jochen Haag, Sandra Krüger, Christoph Röcken   +4 more
doaj   +3 more sources

Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2

Proceedings of the National Academy of Sciences of the United States of America
Significance Existing targeted therapies for solid tumors harboring FGFR2 alterations include pan-FGFR inhibitors, which often cannot be dosed to maximum efficacy due to FGFR1- and FGFR4-mediated toxicities.
Barry Touré, David E Shaw, Pelin Ayaz
exaly   +2 more sources

FGFR2 and favorable survival outcomes in resected poorly cohesive cell gastric cancer: Analysis from FGFR2 protein overexpression and genetic variation. [PDF]

PLoS ONE
PurposePoorly cohesive cell gastric cancer has aggressive and heterogeneous characteristics. This study investigated the clinical significance of fibroblast growth factor receptor 2 expression and genetic variations in patients with PCC-GC.Materials and ...
Yun Ji Lee, Inuk Jung, Jin Ho Baek, Jong Gwang Kim, Ki Bum Park, Ji Yeon Park, Oh Kyoung Kwon, An Na Seo, Moonsik Kim, Byung Woog Kang   +9 more
doaj   +2 more sources