Results 41 to 50 of about 37,073 (238)

Deletion of fibroblast growth factor receptor 2 from the peri-wolffian duct stroma leads to ureteric induction abnormalities and vesicoureteral reflux. [PDF]

PLoS ONE, 2013
Pax3cre-mediated deletion of fibroblast growth factor receptor 2 (Fgfr2) broadly in renal and urinary tract mesenchyme led to ureteric bud (UB) induction defects and vesicoureteral reflux (VUR), although the mechanisms were unclear. Here, we investigated
Kenneth A Walker, Sunder Sims-Lucas, Valeria E Di Giovanni, Caitlin Schaefer, Whitney M Sunseri, Tatiana Novitskaya, Mark P de Caestecker, Feng Chen, Carlton M Bates   +8 more
doaj   +1 more source

Tripod-shaped Syndactyly in Apert Syndrome with FGFR2 p.P253R Mutation

Indian Journal of Plastic Surgery, 2021
Apert syndrome is a rare acrocephalosyndactyly (craniosynostosis) syndrome characterized by craniofacial dysmorphism and syndactyly of the hands and feet. It is caused by FGFR2 mutations and inherited in an autosomal dominant manner.
Chandra Bhan Singh, Biswajit Mishra, Rashmi Patel, Ashok Kumar, Akhtar Ali   +4 more
doaj   +1 more source

FGFR2 mutations are rare across histologic subtypes of ovarian cancer [PDF]

, 2010
OBJECTIVE: Ovarian cancer is the leading cause of death from gynecologic malignancies in the Western world. Fibroblast growth factor receptor (FGFR) signaling has been implicated to play a role in ovarian tumorigenesis.
Goodfellow, Paul, Campbell, Ian, Wellens, Candice, Gartside, Michael, Birrer, Michael, Pollock, Pamela, Byron, Sara, Pamela M. Pollock, Sara A. Byron, Michael J. Birrer, Michael G. Gartside, Candice L. Wellens, Paul J. Goodfellow, Ian G. Campbell   +13 more
core   +1 more source

Clinical Features of Apert Syndrome in Infancy: A rare case in Indonesia

Scripta Score Scientific Medical Journal, 2021
Background: Apert syndrome is characterized by several malformations of cranial-facial and syndactyly. The incidence of Apert syndrome was reported at approximately 1 per 65,000 live births, globally.
Muhammad Pradhika Mapindra, Muhammad Pradhiki Mahindra   +1 more
doaj   +1 more source

Fetal microtia and FGFR2 polymorphism

Experimental and Therapeutic Medicine, 2019
Association of the single-nucleotide polymorphism (SNP) of rs3135718 site in fibroblast growth factor receptor 2 (FGFR2) gene with congenital microtia was investigated. A total of 193 patients with congenital microtia (observation group) and 150 normal and healthy fetuses (control group) treated in Maternity and Child Health Care of Zaozhuang from ...
Zhao, Ruilian, Du, Peixia, Sun, Hongmei, Yang, Li, Lin, Pingzhen   +4 more
openaire   +3 more sources

Serum IgG as a Marker for Opisthorchis viverrini-Associated Cholangiocarcinoma Correlated with HER2 Overexpression

International Journal of General Medicine, 2020
Attapol Titapun,1,2 Anchalee Techasen,2,3 Prakasit Sa-Ngiamwibool,2,4 Paiboon Sithithaworn,2,5 Vor Luvira,1,2 Tharatip Srisuk,1,2 Apiwat Jareanrat,1,2 Hasaya Dokduang,2,6 Watcharin Loilome,2,6 Bandit Thinkhamrop,2,7 Narong Khuntikeo1,2 1Department of ...
Titapun A, Techasen A, Sa-Ngiamwibool P, Sithithaworn P, Luvira V, Srisuk T, Jareanrat A, Dokduang H, Loilome W, Thinkhamrop B, Khuntikeo N   +10 more
doaj  

The significance of FGFR2 protein expression for patients with carcinoma of the stomach in a central European cohort. [PDF]

, 2023
Die Bedeutung des Fibroblasten-Wachstumsfaktor-Rezeptors 2 (FGFR2) im Magenkrebs (GC) wurde vorwiegend an asiatischen Patientenkohorten untersucht. Daten von europäischen Patienten sind rar.
Schrumpf, Thorben
core   +1 more source

Favorable Outcomes in FGFR Fusion-Positive Cholangiocarcinomas and Evolution on Treatment Noted on Circulating Tumor DNA Liquid Biopsies

Case Reports in Oncology, 2020
Cholangiocarcinoma is a very heterogenous cancer and “target-rich” disease. While the current classifications are based on the anatomic location of these tumors (intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, and gallbladder cancer ...
Pashtoon Murtaza Kasi
doaj   +1 more source

Independent roles of Fgfr2 and Frs2 in ureteric epithelium [PDF]

, 2011
Mice with conditional deletion of fibroblast growth factor receptor 2 (Fgfr2) in the ureteric bud using a Hoxb7cre line (Fgfr2UB−/−) develop severe ureteric branching defects; however, ureteric deletion of fibroblast growth factor receptor substrate 2α ...
B. Cusack, Jue Zhang, F. Wang, J. Zhang, Veraragavan P. Eswarakumar, C. M. Bates, Brian Cusack, S. Sims-Lucas, Carlton M. Bates, Fen Wang, V. P. Eswarakumar, Sunder Sims-Lucas   +11 more
core   +1 more source

Functional Distinctions of Endometrial Cancer-Associated Mutations in the Fibroblast Growth Factor Receptor 2 Gene

Cells, 2023
Functional analysis of somatic mutations in tumorigenesis facilitates the development and optimization of personalized therapy for cancer patients. The fibroblast growth factor receptor 2 (FGFR2) gene is frequently mutated in endometrial cancer (EC), but
Garima Dixit, Benjamin A. Pappas, Gourav Bhardwaj, Willow Schanz, Thorsten Maretzky   +4 more
doaj   +1 more source