Results 11 to 20 of about 35,241 (222)

FGFR2 Inhibition in Cholangiocarcinoma.

Annual Review of Medicine, 2022
Biliary tract cancer (BTC) is the second most common primary liver cancer after hepatocellular carcinoma and accounts for 2% of cancer-related deaths. BTCs are classified according to their anatomical origin into intrahepatic (iCCA), perihilar, or distal
A. Vogel, O. Segatto, A. Stenzinger, A. Saborowski   +3 more
semanticscholar   +3 more sources

Incidence of FGFR2 Amplification and FGFR2 Fusion in Patients with Metastatic Cancer Using Clinical Sequencing

Journal of Oncology, 2022
Aberrations in the fibroblast growth factor receptor2 (FGFR2) gene, including genetic alterations and chromosomal rearrangements, lead to the development and progression of cancer with poor prognosis.
S. Hyung, B. Han, Jaeyun Jung, S. Kim, J. Hong, S. Park, D. Zang, Joon-Oh Park, Y. Park, Kyoung-Mee Kim, W. Kang, Jeeyun Lee   +11 more
semanticscholar   +3 more sources

Lower FGFR2 mRNA Expression and Higher Levels of FGFR2 IIIc in HER2-Positive Breast Cancer

Biology
Fibroblast growth factor receptor 2 (FGFR2) has been associated with breast cancer. We performed in silico analyses to investigate the FGFR2 mRNA expression and splice variants associated with breast cancer subtypes.
Thérèse Dix-Peek, Caroline Dickens, Juan Valcárcel, Raquel A. B. Duarte   +3 more
doaj   +3 more sources

Oncogenic activation revealed by FGFR2 genetic alterations in intrahepatic cholangiocarcinomas

Cell & Bioscience, 2023
Background Except for gene fusions, FGFR2 genetic alterations in intrahepatic cholangiocarcinomas (ICCs) have received limited attention, leaving patients harboring activating FGFR2 gene mutations with inadequate access to targeted therapies ...
Xiaohong Pu, Liang Qi, Jia Wu Yan, Zihe Ai, Ping Wu, Fei Yang, Yao Fu, Xing Li, Min Zhang, Beicheng Sun, Shen Yue, Jun Chen   +11 more
doaj   +1 more source

CRISPR/Cas9 mediated FGFR2 down-regulation alleviatespremature closure of cranial suture in an Apert syndromemouse model

生物医学转化, 2021
Apert syndrome (AS) is characterized by synostosis of coronal sutures, midfacial hypoplasia,abnormity of brain, syndactyly of hands and feet. Majority of AS is caused by gain-of-function mutation of fibro‐blast growth factor receptor 2 (FGFR2).
Luo Fengtao, Xie Yangli, Li Can, Tan Qiaoyan, Du Xiaolan, Chen Lin   +5 more
doaj   +1 more source

Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple‐Negative Mammary Tumorigenesis That is Sensitive to Immunotherapy

Advanced Science, 2021
Fibroblast growth factor receptor 2 (FGFR2) is a membrane‐spanning tyrosine kinase that mediates FGF signaling. Various FGFR2 alterations are detected in breast cancer, yet it remains unclear if activation of FGFR2 signaling initiates tumor formation. In
Josh Haipeng Lei, Mi‐Hye Lee, Kai Miao, Zebin Huang, Zhicheng Yao, Aiping Zhang, Jun Xu, Ming Zhao, Zenan Huang, Xin Zhang, Si Chen, NG Jiaying, Yuzhao Feng, Fuqiang Xing, Ping Chen, Heng Sun, Qiang Chen, Tingxiu Xiang, Lin Chen, Xiaoling Xu, Chu‐Xia Deng   +20 more
doaj   +1 more source

FGFR2 mutations promote endometrial cancer progression through dual engagement of EGFR and Notch signalling pathways

Clinical and Translational Medicine, 2023
Background Mutations in the receptor tyrosine kinase gene fibroblast growth factor receptor 2 (FGFR2) occur at a high frequency in endometrial cancer (EC) and have been linked to advanced and recurrent disease.
G. Dixit, J. Gonzalez-Bosquet, Joseph Skurski, E. Devor, E. Dickerson, W. Nothnick, Priya D. Issuree, K. Leslie, Thorsten Maretzky   +8 more
semanticscholar   +1 more source

FGFR2 testing in cholangiocarcinoma: translating molecular studies into clinical practice

Pathologica, 2023
Summary Cholangiocarcinoma (CCA) is a heterogeneous group of neoplasms burdened by a dismal prognosis. Several studies have investigated the genomic profile of CCA and identified numerous druggable genetic alterations, including FGFR2 fusions ...
Valentina Angerilli, L. Fornaro, F. Pepe, Silvia Maria Rossi, G. Perrone, U. Malapelle, M. Fassan   +6 more
semanticscholar   +1 more source

FGFR2 is essential for salivary gland duct homeostasis and MAPK-dependent seromucous acinar cell differentiation

Nature Communications, 2023
Exocrine acinar cells in salivary glands (SG) are critical for oral health and loss of functional acinar cells is a major clinical challenge. Fibroblast growth factor receptors (FGFR) are essential for early development of multiple organs, including SG ...
M. Aure, Jennifer M Symonds, Carlos U Villapudua, Joshua T. Dodge, Sabine Werner, Wendy M Knosp, Matthew P Hoffman   +6 more
semanticscholar   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source