Results 151 to 160 of about 2,012 (174)
Heparan Sulfate Provides a Mechanism to Respond to FGFR2b and Control Regenerative Expansion [PDF]
Journal of Cell Communication and Signaling, 2015 Fast varying 3-O-sulfated groups in epithelial KIT+ progenitors provides a cellular mechanism to respond to FGFR2b-mediated signaling and expansion of fetal and adult progenitors. This is allowed by the synthesis of 3-O-sulfated heparan sulfate that up-regulate KIT and 3-O-sulfotransferase enzymes, augmenting 3-O-sulfated heparan sulfate.
Enrique Brandan
exaly +6 more sources
Cancer Treatment ReviewsGastric and gastroesophageal junction cancer (G/GEJC) is a heterogeneous and complex disease characterized by histologic and molecular subtypes. Although a growing number of treatments have improved survival outcomes in the advanced setting, the greatest therapeutic benefits are observed among patient populations eligible for biomarker-directed ...
Atsushi Ochiai +2 more
exaly +3 more sources
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Cancer Research
Fibroblast growth factor receptor 2b (FGFR2b, FGFR2IIIb), an alternative splicing isoform of FGFR2, is a receptor tyrosine kinases that activates multiple signaling cascades upon binding of FGFs, promoting cancer cell proliferation. It is also a tumor associated antigen overexpressed in multiple solid tumor types, especially gastric cancer (GC). Indeed,
Yibin Xu +18 more
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Fibroblast growth factor receptor 2b (FGFR2b, FGFR2IIIb), an alternative splicing isoform of FGFR2, is a receptor tyrosine kinases that activates multiple signaling cascades upon binding of FGFs, promoting cancer cell proliferation. It is also a tumor associated antigen overexpressed in multiple solid tumor types, especially gastric cancer (GC). Indeed,
Yibin Xu +18 more
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Cancer Research
Abstract Background: Fibroblast growth factor receptor-2b (FGFR2b) is a receptor tyrosine kinase mainly expressed on epithelial cells and involved in numerous cellular functions. Overexpression of FGFR2b in solid tumors, especially gastric cancer, is associated with poor prognosis, making it a ...
Jiajia Pan +6 more
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Abstract Background: Fibroblast growth factor receptor-2b (FGFR2b) is a receptor tyrosine kinase mainly expressed on epithelial cells and involved in numerous cellular functions. Overexpression of FGFR2b in solid tumors, especially gastric cancer, is associated with poor prognosis, making it a ...
Jiajia Pan +6 more
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Role of FGFR2b signaling pathway in the development of ectodermal derivatives
2015The Fibroblast growth factor (FGF) family consists of 23 members, which play important roles during development, homeostasis and pathogenesis by controlling proliferation, migration and differentiation of cells in multiple organs. Among FGFs, we are interested in the role of FGF10 and its receptor, FGFR2b in development of ectodermal derivatives such ...
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Journal of Molecular Histology
Pancreatic development is a complex process vital for maintaining metabolic balance, requiring intricate interactions among different cell types and signaling pathways. Fibroblast growth factor receptors 2b (FGFR2b)-ligands signaling from adjacent mesenchymal cells is crucial in initiating pancreatic development and differentiating exocrine and ...
Li-Li, Jin +10 more
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Pancreatic development is a complex process vital for maintaining metabolic balance, requiring intricate interactions among different cell types and signaling pathways. Fibroblast growth factor receptors 2b (FGFR2b)-ligands signaling from adjacent mesenchymal cells is crucial in initiating pancreatic development and differentiating exocrine and ...
Li-Li, Jin +10 more
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Generation of Rat Lungs by Blastocyst Complementation in Fgfr2b-Deficient Mouse
SSRN Electronic Journal, 2022Shunsuke Yuri +2 more
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Abstract 2964: SCR-A002, a novel FGFR2b-targeting ADC for solid tumors
Cancer ResearchAbstract Background: FGFR2b (fibroblast growth factor receptor 2 IIIb), an isoform of transmembrane tyrosine kinase FGFR family, is overexpressed in various cancers, including gastric, esophageal, breast, hepatocellular, pancreatic, ovary, uterine, cervical, endometrial, lung, colorectal cancers ...
Yayuan Fu +5 more
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Expression of FGFR2b and HER2 in gastric cancer: Implications for targeted therapy selection.
Journal of Clinical Oncologye16106 Background: FGFR2b and HER2 are clinically relevant therapeutic targets in gastric cancer (GC), with multiple targeted agents demonstrating efficacy in biomarker-selected patient populations.
Fei Chu +8 more
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