Results 51 to 60 of about 106,274 (293)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Fiber networks amplify active stress [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Living organisms generate forces to move, change shape, and maintain their internal functions. These forces are typically produced by molecular motors embedded in networks of fibers. Although these motors are traditionally regarded as the defining elements of biological force generation, here we show that the surrounding network ...
Ronceray, Pierre, Broedersz, Chase P., Lenz, Martin   +2 more
openaire   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Coherent beam combining with multilevel optical phase-locked loops [PDF]

, 2007
Coherent beam combining (CBC) technology holds the promise of enabling laser systems with very high power and near-ideal beam quality. We propose and demonstrate a novel servo system composed of multilevel optical phase lock loops.
Aflatouni, Firooz, Hashemi, Hossein, Kewitsch, Anthony, Liang, Wei, Rakuljic, George, Satyan, Naresh, Yariv, Amnon   +6 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Think Outside the Fiber: Imaging Amplifier for Space-Multiplexed Optical Transmission

IEEE Photonics Journal, 2012
This paper proposes a simple and practical method to amplify signals for space-multiplexed optical transmission. In this amplification technique, the output facet of the multicore or multimode fiber is mapped back to the same type of fiber after passing ...
Ibrahim Ozdur, Hong Shu, Michael Bass, Guifang Li   +3 more
doaj   +1 more source

Review of Erbium-doped fiber amplifier [PDF]

, 2011
Data communication systems are increasingly employing optical fiber communication systems (OFCS) as the transmission paths for information. Various types of optical amplifiers have been developed in OFCS to amplify optical signals.
Ahmad, Harith, Al-Khateeb, Wajdi Fawzi Mohammed, Cheng, Xiau San, Hamida, Belal Ahmed, Harun, Sulaiman Wadi, Khan, Sheroz, Mahdi, Mohd Adzir, Naji, Ahmed Wathik, Zaidan, Aws Alaa, Zaidan, Bilal Bahaa   +9 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Extreme Outages due to Polarization Mode Dispersion

, 2003
We investigate the dependence of the bit-error-rate (BER) caused by amplifier noise in a linear optical fiber telecommunication system on the fiber birefringence.
Andresciani, Bergano, Biondini, Bülow, Eyal, Igor Kolokolov, Kaminow, Kogelnik, Machida, Michael Chertkov, Poole, Poole, Poole, Poole, Rashleigh, Ulrich, Vladimir Chernyak, Vladimir Lebedev, Xie   +18 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source