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Nature Reviews Disease Primers, 2022 Atrial fibrillation (AF) is the most common cardiac arrhythmia despite substantial efforts to understand the pathophysiology of the condition and develop improved treatments. Identifying the underlying causative mechanisms of AF in individual patients is difficult and the efficacy of current therapies is suboptimal. Consequently, the incidence of AF is
Bianca J. J. M. Brundel +5 more
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Is This Atrial Fibrillation? [PDF]
Annals of Noninvasive Electrocardiology, 2009 A 19‐year‐old girl was referred to our cardiology department for catheter ablation (isolation of the pulmonary veins) of paroxysmal atrial fibrillation (AF). The diagnosis was made upon a 12‐lead ECG of the arrhythmia documented in the emergency room. The ECG showed an irregular tachycardia without wide QRS complexes.
Jadidi, Amir S. +4 more
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Fibrillation of transferrin [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2012 The nature of fibrillar deposits from aqueous solutions of human serum and recombinant human transferrin on mica and carbon-coated formvar surfaces has been investigated.Atomic force microscopy showed that the deposition of recombinant transferrin onto the hydrophilic surface of mica resulted in the formation of a monolayer-thick film composed of ...
Giovanni Costantini +6 more
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Prognostications of Fibrillations [PDF]
Stroke, 2015 See related article, p 1210. Post-hospital evaluation for the cause of ischemic stroke has gained increased attention in the last decade, particularly the search for paroxysmal atrial fibrillation. Initial studies of Holter monitoring documented rates of atrial fibrillation of ≈5% or 1 in 20 patients.1 Further, prolonged monitoring for as long as 1 ...
Silver, Brian, Windecker, Stephan
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Fibril Breaking Accelerates α-Synuclein Fibrillization [PDF]
The Journal of Physical Chemistry B, 2015 The formation of amyloid fibrils of α-synuclein (αSyn), the key protein in Parkinson's disease, is an autocatalytic process that is seeded by mature αSyn fibrils. Based on systematic measurements of the dependence of the fibril growth rate on the concentrations of monomers and preformed fibrillar seeds, we propose a mechanism of αSyn aggregation that ...
Mireille M.A.E. Claessens +2 more
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Atrial Fibrillation Degenerates Into Ventricular Fibrillation
Journal of the American College of Cardiology, 2010 ![Figure][1] A 43-year-old man with paroxysmal atrial fibrillation (AF) and an implantable cardioverter defibrillator (ICD) placed for documented ventricular fibrillation (VF), presented with an ICD shock. Ventricular pre-excitation was not present.
Ganesh Venkataraman +1 more
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Autoimmune Atrial Fibrillation
Circulation, 2023 BACKGROUND: Atrial fibrillation (AF) is by far the most common cardiac arrhythmia. In about 3% of individuals, AF develops as a primary disorder without any identifiable trigger (idiopathic or historically termed lone AF). In line with the emerging field of autoantibody-related cardiac arrhythmias, the objective of this study ...
Maguy, Ange +4 more
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The Journal of Biomedical Research, 2014 Atrial fibrillation is the most common arrhythmia affecting patients today. Disease prevalence is increasing at an alarming rate worldwide, and is associated with often catastrophic and costly consequences, including heart failure, syncope, dementia, and stroke.
Munger, Thomas M. +2 more
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ABC of Atrial Fibrillation: DRUGS FOR ATRIAL FIBRILLATION [PDF]
BMJ, 1995 One of the most important principles of using antiarrhythmic drugs for controlling any arrhythmia is to treat only patients who are symptomatic, have malignant arrhythmias (such as ventricular fibrillation), or are haemodynamically compromised (for example, with hypotension or heart failure).
Shyam P Singh +2 more
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Genetics of Atrial Fibrillation [PDF]
Medical Clinics of North America, 2006 Recent studies of atrial fibrillation (AF) have identified mutations in a series of ion mutations; however, these channels appear to be relatively rare causes of AF. Recent genome-wide association studies for AF have identified novel variants associated with the disease, although the mechanism of action for these variants remains unknown. Ultimately, a
Calum A. MacRae +2 more
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