Results 111 to 120 of about 15,376 (205)
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.This figure summarises circRNAs identified as therapeutic or pathogenic targets in animal models of diabetic foot ulcers. Protective circRNAs delivered via exosomes, hypoxia‐preconditioned exosomes, or lipid nanoparticles promote angiogenesis, autophagy, and oxidative stress resistance. In contrast, silencing of pathogenic circRNAs such as circ_0005654
Amir Reza Ghafourian +6 more
wiley +1 more source
Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice [PDF]
, 2006 Elastic fibers provide tissues with elasticity which is critical to the function of arteries, lungs, skin, and other dynamic organs. Loss of elasticity is a major contributing factor in aging and diseases.
Broekelmann, Thomas J +10 more
core +3 more sources
Brazilian Journal of Cardiovascular Surgery, 2003 PURPOSE: Bicuspid aortic valve (BAV) is associated with increased prevalence of annulo-aortic ectasia, dissection and ascending aortic aneurysm. This study was undertaken to compare the amount of fibrillin-1 and elastin in the media of great vessels of ...
Mauro Paes Leme +8 more
doaj +1 more source
International Journal of Cancer, Volume 158, Issue 1, Page 120-130, 1 January 2026.What's new? Colorectal cancer (CRC) frequently metastasizes to the liver, either synchronously with primary diagnosis or metachronously, after variable time intervals. Although implicated, the role of genetic factors in driving synchronous and metachronous disease progression remains uncertain.
Marie Rajtmajerova +16 more
wiley +1 more source
Curcumin enhances the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells [PDF]
, 2014 Shu-Mei Lee +4 more
openalex +1 more source
Studies on TGF-β family signalling in the diseased lung tissue [PDF]
, 2012 This thesis focuses on transforming growth factor (TGF)-β signalling system in the human lung. Two lung parenchymal diseases, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD), were studied.
Leppäranta, Outi
core
Collagen Content in Skin and Internal Organs of the Tight Skin Mouse: An Animal Model of Scleroderma. [PDF]
, 2013 The Tight Skin mouse is a genetically induced animal model of tissue fibrosis caused by a large in-frame mutation in the gene encoding fibrillin-1 (Fbn-1). We examined the influence of gender on the collagen content of tissues in C57BL/6J wild type (+/+)
Jimenez, Sergio A +3 more
core +3 more sources
The FEBS Journal, Volume 293, Issue 2, Page 418-442, January 2026.We analysed collagen XV expression in myocardial infarct samples and assessed how its deficiency affects cardiac responses, such as fibrogenesis and tissue stiffness. In mice, damage caused by myocardial infarction is exacerbated in the absence of collagen XV and leads to pathological remodelling and more severe left ventricle dysfunction (left panel ...
Sanna‐Maria Karppinen +15 more
wiley +1 more source
A Mutant \u3cem\u3edec-1\u3c/em\u3e Transgene Induces Dominant Female Sterility in \u3cem\u3eDrosophila melanogaster\u3c/em\u3e [PDF]
, 2007 The Drosophila dec-1 gene produces three proproteins required for female fertility and eggshell assembly. The three proproteins are distinguished by their C termini.
Spangenberg, Daniel K., Waring, Gail L.
core +1 more source
Multi-exon deletions of the
BMC Medical Genetics, 2001 Background Mutations in the fibrillin -1 gene (FBN1) cause Marfan syndrome (MFS), an autosomal dominant multi-system connective tissue disorder. The 200 different mutations reported in the 235 kb, 65 exon-containing gene include only one family with a ...
Schrijver Iris +4 more
doaj +1 more source