Results 61 to 70 of about 12,218 (212)
Disease Models & Mechanisms, 2019 Fibrillin is an evolutionarily ancient protein that lends elasticity and resiliency to a variety of tissues. In humans, mutations in fibrillin-1 cause Marfan and related syndromes, conditions in which the eye is often severely affected.
Wendell Jones +2 more
doaj +1 more source
Stem Cell Research, 2023 Marfan syndrome is an autosomal dominant genetic disorder resulting from pathogenic variants in FBN1 gene. FBN1 encodes for fibrillin-1, an important extracellular matrix protein.
Jeffrey Aalders +7 more
doaj +1 more source
Innate immunity shapes the persistent transmission of plant viruses by insect vectors
New Plant Protection, EarlyView.In this review, we focus on two key aspects of the virus–vector interplay: (1) persistently transmitted viruses utilize host factors to overcome transmission barriers; and (2) molecular recognition activates antiviral immunity and subsequent viral counter‐defense. Understanding these interactions offers critical insights for developing novel strategies
Gang Lu, Chuanxi Zhang, Junmin Li
wiley +1 more source
Frontiers in Cardiovascular Medicine, 2021 Medial deterioration leading to thoracic aortic aneurysms arises from multiple causes, chief among them mutations to the gene that encodes fibrillin-1 and leads to Marfan syndrome.
Cristina Cavinato +7 more
doaj +1 more source
The FEBS Journal, EarlyView.Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley +1 more source
Fibrillines et fibrillinopathies [PDF]
médecine/sciences, 1996 Microfibrils contain a variety of proteins, the most prominent of which are the two fibrillins. Fibrillins are large glycoproteins (320 kDa) ubiquitously distributed in connective tissues. Together with amorphous elastin, fibrillin-containing microfibrils form the elastic fibers.
Collod-Beroud, Gwenaëlle +1 more
openaire +2 more sources
PLoS ONE, 2012 The extracellular glycoprotein fibrillin-1 forms microfibrils that act as the template for elastic fibers. Most mutations in fibrillin-1 cause Marfan syndrome with severe cardiovascular and ocular symptoms, and tall stature.
Stuart A Cain +4 more
doaj +1 more source
BMC Cardiovascular Disorders, 2020 Background Elderly patients have a relatively high cardiovascular risk due to increased arterial stiffness, elevated blood pressure and decreased amounts of elastin in the arteries.
Ida Åström Malm +4 more
doaj +1 more source
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
, 2012 (A) Domain structures of fibrillin-1 and fibrillin-2 are shown, with a key of the different domains, N-glycosylation sites, and the C-terminal furin cleavage site. Fibrillin-1 contains a proline-rich region and fibrillin-2 contains a glycine-rich region.
Amanda McGovern (123689) +4 more
core +1 more source